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OPENSEQ.org
MAZG - Nucleoside triphosphate pyrophosphohydrolase
UniProt: P0AEY3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10572
Length: 263 (257)
Sequences: 1130
Seq/Len: 4.40
MAZG
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
250_E 254_Q 4.604 1.00
71_Q 74_Q 3.372 1.00
234_V 244_V 3.221 1.00
146_Q 212_A 2.951 1.00
170_Y 177_M 2.89 1.00
10_I 89_S 2.776 1.00
43_V 55_L 2.749 1.00
8_L 81_F 2.624 1.00
94_R 118_I 2.498 1.00
141_A 213_E 2.429 1.00
29_F 69_Y 2.422 1.00
229_E 256_V 2.394 1.00
233_I 236_A 2.378 1.00
30_A 50_E 2.34 1.00
191_E 218_K 2.324 1.00
26_E 108_S 2.31 1.00
148_I 220_N 2.293 1.00
176_V 194_M 2.287 1.00
11_M 68_F 2.213 1.00
4_I 81_F 2.191 1.00
224_E 228_R 2.157 1.00
168_K 171_E 2.134 1.00
239_L 248_T 2.134 1.00
244_V 249_M 2.09 1.00
144_R 224_E 1.955 1.00
43_V 62_L 1.902 1.00
237_R 252_V 1.877 1.00
194_M 201_T 1.865 1.00
107_N 110_E 1.797 1.00
130_S 228_R 1.794 1.00
103_S 114_R 1.792 1.00
179_E 189_K 1.787 1.00
234_V 241_M 1.78 1.00
245_D 248_T 1.75 0.99
52_F 78_R 1.704 0.99
142_L 202_V 1.701 0.99
189_K 192_E 1.699 0.99
169_V 200_A 1.684 0.99
194_M 210_T 1.668 0.99
192_E 222_K 1.655 0.99
80_D 83_D 1.637 0.99
165_V 204_L 1.627 0.99
16_D 19_N 1.615 0.99
170_Y 174_D 1.613 0.99
188_A 218_K 1.582 0.99
40_T 44_L 1.565 0.99
210_T 215_A 1.564 0.99
54_D 57_G 1.561 0.99
161_T 164_P 1.552 0.98
105_A 111_V 1.548 0.98
233_I 255_Q 1.546 0.98
86_A 90_D 1.545 0.98
45_D 49_R 1.526 0.98
234_V 249_M 1.507 0.98
19_N 25_K 1.504 0.98
229_E 233_I 1.461 0.98
4_I 85_C 1.457 0.97
108_S 111_V 1.454 0.97
90_D 94_R 1.444 0.97
36_T 69_Y 1.423 0.97
5_D 9_T 1.404 0.97
74_Q 80_D 1.4 0.97
32_I 36_T 1.397 0.97
230_V 244_V 1.393 0.96
105_A 114_R 1.386 0.96
241_M 244_V 1.383 0.96
15_R 75_E 1.382 0.96
67_V 88_I 1.368 0.96
237_R 255_Q 1.357 0.96
17_P 20_G 1.345 0.95
12_Q 71_Q 1.309 0.94
32_I 72_M 1.306 0.94
29_F 36_T 1.302 0.94
169_V 197_L 1.297 0.94
176_V 190_L 1.287 0.94
63_L 85_C 1.275 0.93
70_A 84_I 1.268 0.93
111_V 114_R 1.267 0.93
63_L 66_V 1.262 0.93
51_D 54_D 1.241 0.92
192_E 197_L 1.209 0.91
123_R 151_R 1.208 0.91
192_E 219_A 1.205 0.91
160_T 164_P 1.197 0.90
56_R 87_A 1.197 0.90
239_L 243_G 1.173 0.89
229_E 255_Q 1.167 0.89
81_F 85_C 1.167 0.89
52_F 76_E 1.163 0.88
234_V 252_V 1.153 0.88
166_V 177_M 1.145 0.87
164_P 167_D 1.13 0.86
194_M 205_A 1.127 0.86
241_M 249_M 1.12 0.86
33_A 48_A 1.114 0.85
56_R 73_A 1.101 0.85
136_P 139_L 1.099 0.84
176_V 197_L 1.096 0.84
28_T 31_T 1.09 0.84
191_E 214_I 1.084 0.83
33_A 44_L 1.082 0.83
240_E 243_G 1.079 0.83
176_V 201_T 1.078 0.83
186_D 189_K 1.078 0.83
174_D 177_M 1.068 0.82
32_I 35_Y 1.066 0.82
149_Q 158_D 1.059 0.81
29_F 55_L 1.055 0.81
16_D 25_K 1.052 0.81
6_R 90_D 1.05 0.80
198_L 201_T 1.046 0.80
89_S 93_E 1.046 0.80
134_D 151_R 1.042 0.80
141_A 216_L 1.034 0.79
49_R 54_D 1.028 0.78
157_F 227_F 1.027 0.78
7_L 88_I 1.022 0.78
146_Q 211_K 1.008 0.77
56_R 83_D 1.005 0.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3craA20.99241000.067Contact Map0.783
2yxhA20.44111000.677Contact Map0.679
2a3qA20.551399.90.786Contact Map0.481
2oieA40.361299.80.803Contact Map0.564
3obcA20.368899.70.816Contact Map0.525
2q5zA20.395499.70.825Contact Map0.564
2gtaA40.406899.60.833Contact Map0.615
2q73A40.34699.60.833Contact Map0.65
1vmgA10.349899.60.838Contact Map0.393
1yxbA80.349896.20.933Contact Map0.568
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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