OPENSEQ.org - FKBX - ECOLI GREMLIN

May 4, 2021 - We are working on upgrading the webserver, some pages may not work.

FKBX - FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase

UniProt:	P0AEM0	Sequence MSESVQSNSAVLVHFTLKLDDGTTAESTRNNGKPALFRLGDASLSEGLEQHLLGLKVGDKTTFSLEPDAAFGVPSPDLIQYFSRREFMDAGEPEIGAIMLFTAMDGSEMPGVIREINGDSITVDFNHPLAGQTVHFDIEVLEIDPALEA	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG11080
Length:	149 (143)
Sequences:	1361
Seq/Len:	9.52

FKBX
Paralog alert: 0.60 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FKBX SLYD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
67_P	133_T	4.399	1.00
60_K	139_E	3.886	1.00
68_D	73_V	3.274	1.00
50_Q	69_A	3.172	1.00
62_T	137_D	3.1	1.00
55_L	61_T	2.528	1.00
17_L	25_A	2.365	1.00
51_H	63_F	2.217	1.00
56_K	59_D	2.206	1.00
66_E	133_T	2.196	1.00
9_S	145_P	2.027	1.00
57_V	142_E	1.98	1.00
66_E	69_A	1.927	1.00
5_V	39_L	1.919	1.00
87_F	121_I	1.85	1.00
12_L	142_E	1.843	1.00
81_Y	120_S	1.83	1.00
7_S	53_L	1.816	1.00
20_D	135_H	1.767	1.00
16_T	27_S	1.746	1.00
111_G	125_F	1.72	1.00
57_V	143_I	1.711	1.00
84_R	121_I	1.697	1.00
60_K	137_D	1.641	1.00
14_H	139_E	1.607	1.00
65_L	70_A	1.602	1.00
95_I	116_I	1.598	1.00
5_V	140_V	1.57	1.00
55_L	59_D	1.562	1.00
10_A	144_D	1.56	1.00
74_P	79_I	1.554	1.00
16_T	137_D	1.523	1.00
13_V	48_L	1.51	1.00
4_S	56_K	1.502	1.00
14_H	28_T	1.499	1.00
81_Y	122_T	1.451	1.00
115_E	122_T	1.411	0.99
37_F	52_L	1.401	0.99
111_G	123_V	1.391	0.99
45_S	65_L	1.383	0.99
12_L	36_L	1.322	0.99
64_S	133_T	1.312	0.99
16_T	24_T	1.311	0.99
84_R	119_D	1.293	0.99
14_H	27_S	1.278	0.99
39_L	49_E	1.273	0.99
64_S	135_H	1.272	0.99
10_A	38_R	1.266	0.99
46_E	50_Q	1.244	0.98
101_F	111_G	1.222	0.98
39_L	53_L	1.222	0.98
94_E	97_A	1.213	0.98
44_L	48_L	1.204	0.98
5_V	143_I	1.198	0.98
80_Q	83_S	1.181	0.97
6_Q	9_S	1.179	0.97
41_D	49_E	1.156	0.97
62_T	135_H	1.152	0.97
45_S	71_F	1.146	0.97
9_S	143_I	1.142	0.97
5_V	54_G	1.138	0.97
71_F	134_V	1.125	0.96
16_T	29_R	1.124	0.96
19_L	25_A	1.121	0.96
18_K	24_T	1.104	0.96
79_I	122_T	1.102	0.96
19_L	23_T	1.088	0.95
14_H	29_R	1.069	0.95
20_D	133_T	1.065	0.94
11_V	143_I	1.045	0.94
20_D	64_S	1.045	0.94
8_N	41_D	1.042	0.94
48_L	138_I	1.035	0.93
61_T	138_I	1.011	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
4dt4A	1	1	100	0.102	Contact Map	0.786
2kfwA	1	0.9732	100	0.12	Contact Map	0.682
2k8iA	1	0.9732	100	0.123	Contact Map	0.73
2kr7A	1	0.9799	100	0.139	Contact Map	0.671
3cgmA	1	0.9463	100	0.154	Contact Map	0.865
1ix5A	1	0.9195	100	0.18	Contact Map	0.834
3prbA	2	0.9396	100	0.194	Contact Map	0.915
3pr9A	1	0.9396	100	0.199	Contact Map	0.918
2lknA	1	0.9195	99.9	0.487	Contact Map	0.679
1kt0A	1	0.9799	99.8	0.542	Contact Map	0.483

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.3248 seconds.