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OPENSEQ.org
FDOI - Formate dehydrogenase, cytochrome b556(fdo) subunit
UniProt: P0AEL0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11856
Length: 211 (202)
Sequences: 953
Seq/Len: 4.72
FDOI
Paralog alert: 0.57 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: CYBH FDNI FDOI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
21_T 67_S 2.545 1.00
65_F 130_V 2.466 1.00
27_L 60_V 2.271 1.00
61_G 64_M 2.241 1.00
8_V 185_W 2.151 1.00
64_M 122_L 2.078 1.00
20_I 67_S 1.925 1.00
192_K 199_Y 1.887 1.00
8_V 11_T 1.742 1.00
124_L 156_A 1.732 1.00
86_I 90_K 1.716 0.99
128_S 152_L 1.701 0.99
106_R 111_Q 1.689 0.99
107_Y 111_Q 1.634 0.99
188_S 203_R 1.63 0.99
24_C 126_L 1.607 0.99
24_C 63_V 1.606 0.99
22_A 168_I 1.59 0.99
10_Y 107_Y 1.573 0.99
27_L 56_L 1.566 0.99
36_L 154_S 1.517 0.98
93_R 99_E 1.422 0.97
85_D 112_K 1.406 0.97
11_T 14_E 1.403 0.97
125_L 156_A 1.397 0.97
62_V 66_A 1.383 0.97
171_A 178_I 1.368 0.96
132_I 150_L 1.345 0.96
62_V 133_W 1.333 0.96
33_L 157_A 1.319 0.95
58_P 61_G 1.298 0.95
58_P 133_W 1.298 0.95
114_V 117_A 1.295 0.95
191_A 198_W 1.286 0.95
151_M 155_F 1.28 0.94
16_I 70_I 1.274 0.94
84_D 197_R 1.271 0.94
52_L 56_L 1.262 0.94
176_G 186_V 1.262 0.94
87_F 90_K 1.253 0.93
23_F 27_L 1.239 0.93
148_F 152_L 1.239 0.93
83_R 86_I 1.233 0.93
200_R 203_R 1.216 0.92
155_F 168_I 1.212 0.92
131_I 182_V 1.209 0.92
201_E 204_K 1.207 0.92
137_F 140_A 1.201 0.91
188_S 199_Y 1.197 0.91
105_G 201_E 1.187 0.91
196_P 200_R 1.187 0.91
120_I 164_I 1.182 0.91
179_T 183_E 1.165 0.90
85_D 88_W 1.164 0.90
193_K 196_P 1.154 0.89
34_G 53_A 1.153 0.89
9_R 186_V 1.152 0.89
103_D 196_P 1.139 0.88
128_S 131_I 1.139 0.88
12_A 16_I 1.126 0.88
120_I 124_L 1.121 0.87
190_W 195_H 1.115 0.87
38_P 54_R 1.109 0.86
48_G 147_R 1.1 0.86
142_S 145_V 1.098 0.86
199_Y 202_V 1.084 0.85
68_F 126_L 1.082 0.85
30_V 151_M 1.074 0.84
26_I 30_V 1.073 0.84
117_A 159_A 1.069 0.84
146_I 150_L 1.067 0.83
25_F 160_L 1.067 0.83
16_I 128_S 1.066 0.83
54_R 58_P 1.062 0.83
21_T 71_M 1.058 0.83
9_R 85_D 1.058 0.83
94_K 102_G 1.053 0.82
154_S 158_V 1.05 0.82
117_A 121_F 1.048 0.82
21_T 24_C 1.046 0.82
60_V 163_V 1.042 0.81
103_D 197_R 1.042 0.81
191_A 194_H 1.039 0.81
49_T 52_L 1.038 0.81
64_M 166_V 1.032 0.81
17_N 68_F 1.027 0.80
79_N 88_W 1.027 0.80
61_G 86_I 1.026 0.80
69_I 127_V 1.024 0.80
85_D 102_G 1.023 0.80
168_I 171_A 1.022 0.80
49_T 128_S 1.02 0.80
200_R 204_K 1.019 0.79
197_R 200_R 1.016 0.79
196_P 203_R 1.016 0.79
27_L 148_F 1.011 0.79
84_D 128_S 1.011 0.79
30_V 47_M 1.011 0.79
112_K 116_W 1.008 0.78
83_R 87_F 1.008 0.78
104_T 109_F 1.006 0.78
120_I 130_V 1.002 0.78
111_Q 179_T 1.002 0.78
169_Y 176_G 1 0.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1kqfC111000.305Contact Map0.534
4gd3A20.92421000.537Contact Map0.552
2qjyA60.966864.80.933Contact Map0.439
4h44A10.7915640.933Contact Map0.481
1pp9C20.938462.30.934Contact Map0.469
3cx5C20.947946.30.94Contact Map0.339
2czsA20.14696.30.96Contact Map0.531
2gsmA20.85313.70.964Contact Map0.185
3ixzA10.42182.30.968Contact Map0.04
2bs2C20.37442.10.969Contact Map0.327
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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