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OPENSEQ.org
DACA - D-alanyl-D-alanine carboxypeptidase DacA
UniProt: P0AEB2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10201
Length: 403 (363)
Sequences: 1554
Seq/Len: 4.28
DACA
Paralog alert: 0.50 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: DACA DACC DACD PBP7
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
66_D 192_R 4.161 1.00
128_V 147_M 3.274 1.00
51_L 288_G 3.264 1.00
62_E 65_A 3.051 1.00
264_L 288_G 3.004 1.00
101_G 149_D 2.856 1.00
83_I 147_M 2.826 1.00
198_G 241_I 2.736 1.00
134_G 140_G 2.617 1.00
239_D 263_R 2.597 1.00
127_P 130_Q 2.556 1.00
66_D 173_N 2.534 1.00
155_Q 179_V 2.499 1.00
68_R 188_Y 2.496 1.00
258_T 261_Q 2.49 1.00
360_T 372_Q 2.472 1.00
135_I 147_M 2.46 1.00
64_N 67_V 2.438 1.00
171_L 197_I 2.438 1.00
97_L 125_Q 2.415 1.00
133_R 214_E 2.389 1.00
135_I 144_C 2.373 1.00
314_S 379_Q 2.313 1.00
152_A 161_L 2.273 1.00
348_L 358_V 2.253 1.00
81_Y 200_A 2.244 1.00
96_D 150_F 2.197 1.00
352_L 377_V 2.141 1.00
154_S 157_A 2.111 1.00
97_L 127_P 2.091 1.00
165_Y 168_A 2.077 1.00
169_L 200_A 2.063 1.00
198_G 254_V 2.02 1.00
77_M 254_V 2.02 1.00
296_N 299_K 2.009 1.00
51_L 264_L 2.009 1.00
353_Q 380_E 1.938 1.00
320_G 378_L 1.927 1.00
95_T 129_S 1.919 1.00
237_N 259_E 1.915 1.00
102_N 122_P 1.905 1.00
85_Q 165_Y 1.899 1.00
54_Y 265_I 1.851 1.00
357_V 374_P 1.807 1.00
152_A 157_A 1.802 1.00
48_S 191_A 1.797 1.00
257_A 289_F 1.794 1.00
266_S 281_S 1.785 1.00
157_A 160_G 1.761 0.99
78_M 174_T 1.754 0.99
103_D 149_D 1.75 0.99
49_Y 61_A 1.749 0.99
239_D 256_S 1.746 0.99
192_R 196_L 1.674 0.99
306_S 316_R 1.662 0.99
255_A 281_S 1.658 0.99
83_I 135_I 1.653 0.99
101_G 104_A 1.638 0.99
78_M 166_V 1.638 0.99
280_E 283_K 1.636 0.99
358_V 377_V 1.612 0.99
100_I 146_A 1.593 0.99
80_S 135_I 1.586 0.99
194_M 254_V 1.586 0.99
191_A 269_M 1.567 0.99
99_T 125_Q 1.553 0.98
160_G 164_S 1.548 0.98
98_V 146_A 1.543 0.98
357_V 360_T 1.536 0.98
199_Q 265_I 1.534 0.98
98_V 150_F 1.53 0.98
53_D 262_M 1.53 0.98
175_H 188_Y 1.529 0.98
74_L 194_M 1.522 0.98
48_S 69_R 1.495 0.98
362_N 372_Q 1.488 0.98
68_R 173_N 1.463 0.97
174_T 189_S 1.458 0.97
74_L 254_V 1.458 0.97
215_K 232_W 1.457 0.97
183_D 248_K 1.451 0.97
133_R 137_L 1.44 0.97
364_Q 369_T 1.44 0.97
79_T 144_C 1.439 0.97
71_P 189_S 1.438 0.97
246_T 249_A 1.436 0.97
209_Y 256_S 1.435 0.97
369_T 372_Q 1.419 0.97
356_Q 377_V 1.415 0.97
341_Y 375_L 1.405 0.96
171_L 196_L 1.398 0.96
353_Q 356_Q 1.388 0.96
354_K 380_E 1.388 0.96
202_I 209_Y 1.36 0.96
249_A 252_N 1.352 0.95
300_V 324_D 1.352 0.95
134_G 143_A 1.348 0.95
139_S 243_T 1.335 0.95
94_E 129_S 1.331 0.95
309_V 350_A 1.328 0.95
93_K 96_D 1.324 0.95
164_S 168_A 1.316 0.94
50_I 192_R 1.314 0.94
129_S 133_R 1.307 0.94
50_I 65_A 1.306 0.94
256_S 263_R 1.298 0.94
77_M 201_L 1.297 0.94
364_Q 367_G 1.287 0.94
340_S 364_Q 1.286 0.93
177_Q 186_G 1.286 0.93
87_M 208_E 1.285 0.93
74_L 269_M 1.284 0.93
207_N 210_S 1.283 0.93
102_N 106_A 1.281 0.93
70_D 183_D 1.278 0.93
80_S 132_I 1.276 0.93
77_M 241_I 1.275 0.93
139_S 242_K 1.274 0.93
81_Y 165_Y 1.267 0.93
238_V 255_A 1.263 0.93
200_A 204_D 1.261 0.93
80_S 136_N 1.258 0.92
86_A 91_K 1.252 0.92
92_F 150_F 1.25 0.92
144_C 179_V 1.25 0.92
362_N 369_T 1.248 0.92
94_E 132_I 1.245 0.92
296_N 326_Y 1.242 0.92
177_Q 184_A 1.24 0.92
88_K 207_N 1.239 0.92
49_Y 63_Q 1.234 0.92
312_G 350_A 1.226 0.91
210_S 213_K 1.218 0.91
81_Y 204_D 1.208 0.90
298_L 321_V 1.207 0.90
325_V 371_E 1.207 0.90
100_I 120_L 1.201 0.90
313_D 382_P 1.196 0.90
70_D 248_K 1.194 0.90
75_T 187_Q 1.193 0.90
317_A 377_V 1.191 0.90
83_I 92_F 1.177 0.89
118_M 134_G 1.175 0.89
309_V 312_G 1.175 0.89
83_I 128_V 1.161 0.88
384_G 388_G 1.146 0.87
68_R 190_S 1.14 0.87
318_S 378_L 1.137 0.86
82_V 86_A 1.13 0.86
72_A 249_A 1.128 0.86
48_S 64_N 1.128 0.86
307_E 319_L 1.12 0.85
77_M 198_G 1.12 0.85
172_K 192_R 1.103 0.84
48_S 269_M 1.098 0.84
234_N 237_N 1.096 0.84
287_W 292_F 1.095 0.83
299_K 302_K 1.094 0.83
253_L 281_S 1.083 0.83
383_E 389_K 1.079 0.82
140_G 143_A 1.075 0.82
299_K 324_D 1.073 0.82
52_I 195_A 1.072 0.82
137_L 214_E 1.064 0.81
317_A 381_I 1.064 0.81
129_S 211_I 1.063 0.81
342_V 362_N 1.062 0.81
169_L 197_I 1.058 0.80
255_A 285_L 1.057 0.80
333_R 336_D 1.048 0.80
87_M 92_F 1.048 0.80
377_V 380_E 1.045 0.79
391_I 395_K 1.029 0.78
322_D 374_P 1.029 0.78
165_Y 200_A 1.029 0.78
319_L 358_V 1.026 0.78
255_A 266_S 1.017 0.77
180_H 183_D 1.016 0.77
166_V 176_F 1.008 0.76
111_V 114_G 1.007 0.76
177_Q 187_Q 1.006 0.76
175_H 186_G 1.001 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3mzfA10.89331000.283Contact Map0.833
4k91A20.85861000.295Contact Map0.856
3itaA40.8661000.302Contact Map0.836
3a3jA10.85111000.315Contact Map0.84
1xp4A40.85611000.321Contact Map0.843
3mfdA20.80891000.34Contact Map0.809
3hunA20.9381000.413Contact Map0.847
1tvfA20.83131000.434Contact Map0.851
2bcfA10.66251000.522Contact Map0.753
1es5A10.61041000.537Contact Map0.823
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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