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OPENSEQ.org

MAZF - mRNA interferase MazF
UniProt: P0AE70 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11249
Length: 111 (107)
Sequences: 1047
Seq/Len: 9.79

MAZF
Paralog alert: 0.40 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: CHPB MAZF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_V 102_I 3.106 1.00
17_F 31_A 2.804 1.00
61_E 76_D 2.676 1.00
95_A 98_E 2.543 1.00
49_V 73_A 2.447 1.00
14_W 91_K 2.438 1.00
9_M 103_K 2.257 1.00
24_E 86_R 2.04 1.00
15_V 31_A 2.02 1.00
11_D 93_T 1.981 1.00
20_T 26_A 1.856 1.00
73_A 102_I 1.846 1.00
34_L 49_V 1.724 1.00
10_G 99_L 1.7 1.00
17_F 79_K 1.69 1.00
25_Q 74_L 1.675 1.00
101_L 105_K 1.609 1.00
31_A 81_I 1.578 1.00
13_I 87_G 1.573 1.00
25_Q 29_R 1.534 1.00
32_V 94_V 1.513 1.00
49_V 75_A 1.497 1.00
68_E 92_G 1.432 1.00
20_T 79_K 1.409 0.99
69_R 92_G 1.371 0.99
15_V 81_I 1.357 0.99
16_D 28_H 1.314 0.99
53_T 70_D 1.312 0.99
34_L 106_I 1.303 0.99
8_D 37_F 1.255 0.99
82_A 85_A 1.252 0.98
39_Y 109_L 1.213 0.98
66_G 92_G 1.213 0.98
78_V 106_I 1.157 0.97
7_P 33_V 1.143 0.97
39_Y 45_M 1.133 0.97
98_E 101_L 1.131 0.97
94_V 98_E 1.121 0.96
11_D 90_K 1.114 0.96
22_G 86_R 1.102 0.96
103_K 110_I 1.099 0.96
67_Q 92_G 1.074 0.95
19_P 79_K 1.055 0.94
17_F 20_T 1.047 0.94
51_C 71_G 1.037 0.94
67_Q 71_G 1.031 0.93
14_W 89_T 1.027 0.93
48_C 81_I 1.026 0.93
59_P 62_V 1.012 0.93
47_L 109_L 1.006 0.92
13_I 33_V 1.004 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ub4A20.9911000.139Contact Map0.716
1m1fA20.94591000.179Contact Map0.835
4mdxA20.9641000.194Contact Map0.814
1ne8A10.9641000.197Contact Map0.756
2kmtA20.855999.20.618Contact Map0.499
3vubA10.828898.80.669Contact Map0.632
3nr7A20.369460.931Contact Map0.804
2faoA20.918940.936Contact Map0.138
1y88A10.9643.80.937Contact Map0.249
3pmiA40.80183.70.938Contact Map0.18

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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