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OPENSEQ.org
YHBW - Uncharacterized protein YhbW
UniProt: P0ADV5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12792
Length: 335 (329)
Sequences: 6630
Seq/Len: 20.15
YHBW
Paralog alert: 0.65 [within 20: 0.19] - ratio of genomes with paralogs
Cluster includes: RUTA SSUD YHBW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
232_N 290_K 6.366 1.00
34_R 70_N 3.62 1.00
232_N 287_D 3.407 1.00
136_P 182_Q 3.342 1.00
296_Q 300_R 3.128 1.00
294_G 297_S 2.965 1.00
35_L 38_K 2.869 1.00
37_E 73_T 2.862 1.00
64_I 76_L 2.859 1.00
287_D 290_K 2.7 1.00
231_S 234_D 2.673 1.00
203_H 207_S 2.594 1.00
177_A 204_L 2.463 1.00
181_A 208_N 2.411 1.00
34_R 38_K 2.408 1.00
178_Q 208_N 2.369 1.00
233_R 237_F 2.344 1.00
229_A 234_D 2.339 1.00
232_N 236_E 2.318 1.00
199_F 203_H 2.309 1.00
204_L 208_N 2.295 1.00
75_H 107_D 2.281 1.00
68_A 102_Y 2.262 1.00
324_E 328_D 2.253 1.00
140_A 183_L 2.241 1.00
35_L 324_E 2.227 1.00
202_L 220_A 2.162 1.00
30_L 34_R 2.149 1.00
68_A 76_L 2.146 1.00
321_H 324_E 2.099 1.00
147_D 164_K 2.025 1.00
67_L 76_L 2.005 1.00
27_S 103_P 2 1.00
209_F 218_P 1.999 1.00
207_S 211_P 1.999 1.00
99_N 104_G 1.996 1.00
31_D 34_R 1.971 1.00
95_F 106_I 1.95 1.00
33_A 44_Y 1.921 1.00
326_A 330_K 1.918 1.00
45_W 77_G 1.91 1.00
44_Y 74_L 1.904 1.00
202_L 206_R 1.893 1.00
39_R 327_M 1.871 1.00
199_F 301_E 1.833 1.00
289_A 293_H 1.809 1.00
240_T 244_Q 1.802 1.00
33_A 67_L 1.8 1.00
38_K 72_T 1.798 1.00
222_V 304_A 1.776 1.00
30_L 70_N 1.758 1.00
178_Q 211_P 1.738 1.00
37_E 71_T 1.736 1.00
95_F 108_L 1.715 1.00
297_S 301_E 1.711 1.00
140_A 144_D 1.686 1.00
37_E 72_T 1.657 1.00
288_K 325_L 1.641 1.00
35_L 39_R 1.634 1.00
290_K 293_H 1.622 1.00
178_Q 182_Q 1.573 1.00
321_H 325_L 1.546 1.00
144_D 148_A 1.542 1.00
284_L 291_V 1.54 1.00
200_Q 203_H 1.527 1.00
208_N 211_P 1.525 1.00
143_V 167_V 1.504 1.00
143_V 164_K 1.504 1.00
289_A 333_L 1.484 1.00
230_D 234_D 1.471 1.00
139_V 183_L 1.466 1.00
33_A 71_T 1.454 1.00
178_Q 212_S 1.448 1.00
296_Q 299_L 1.434 1.00
234_D 238_L 1.432 1.00
46_L 64_I 1.431 1.00
136_P 140_A 1.431 1.00
7_A 42_H 1.417 1.00
136_P 183_L 1.416 1.00
59_A 62_V 1.41 1.00
229_A 235_A 1.404 0.99
181_A 212_S 1.384 0.99
293_H 297_S 1.381 0.99
143_V 183_L 1.38 0.99
77_G 107_D 1.378 0.99
228_A 291_V 1.376 0.99
66_Y 101_L 1.375 0.99
59_A 94_Q 1.372 0.99
122_M 153_P 1.366 0.99
234_D 237_F 1.365 0.99
110_L 139_V 1.364 0.99
204_L 207_S 1.362 0.99
27_S 31_D 1.356 0.99
86_H 94_Q 1.309 0.99
30_L 66_Y 1.3 0.99
141_E 144_D 1.29 0.99
219_Y 305_D 1.289 0.99
293_H 296_Q 1.28 0.99
21_S 24_E 1.267 0.99
292_R 296_Q 1.266 0.99
118_Q 122_M 1.264 0.99
61_S 81_V 1.263 0.99
171_G 187_F 1.251 0.99
169_L 176_S 1.249 0.99
228_A 288_K 1.241 0.98
325_L 329_V 1.24 0.98
133_D 175_Y 1.239 0.98
182_Q 212_S 1.236 0.98
286_G 291_V 1.236 0.98
66_Y 69_A 1.227 0.98
46_L 67_L 1.225 0.98
16_I 22_A 1.203 0.98
237_F 241_S 1.202 0.98
143_V 185_L 1.197 0.98
35_L 320_L 1.193 0.98
39_R 323_F 1.187 0.98
144_D 149_R 1.186 0.98
309_V 326_A 1.181 0.98
96_G 161_Y 1.174 0.98
237_F 240_T 1.174 0.98
10_L 36_A 1.166 0.97
58_A 97_T 1.162 0.97
230_D 329_V 1.159 0.97
26_F 101_L 1.155 0.97
27_S 30_L 1.149 0.97
98_L 106_I 1.14 0.97
27_S 72_T 1.134 0.97
239_F 243_Q 1.131 0.97
177_A 208_N 1.129 0.97
28_H 316_H 1.128 0.97
90_V 94_Q 1.128 0.97
41_Y 327_M 1.126 0.97
224_I 295_L 1.12 0.96
91_I 138_D 1.115 0.96
234_D 318_A 1.11 0.96
228_A 325_L 1.106 0.96
315_D 318_A 1.106 0.96
230_D 321_H 1.106 0.96
137_R 141_E 1.105 0.96
297_S 300_R 1.102 0.96
175_Y 178_Q 1.101 0.96
316_H 320_L 1.083 0.96
62_V 98_L 1.082 0.96
108_L 142_L 1.079 0.95
181_A 209_F 1.075 0.95
179_L 183_L 1.07 0.95
64_I 78_S 1.066 0.95
31_D 35_L 1.066 0.95
36_A 323_F 1.059 0.95
209_F 215_L 1.056 0.95
290_K 294_G 1.055 0.95
168_W 221_M 1.053 0.95
239_F 285_V 1.045 0.94
130_G 133_D 1.044 0.94
177_A 181_A 1.042 0.94
81_V 91_I 1.037 0.94
99_N 164_K 1.037 0.94
24_E 28_H 1.034 0.94
146_F 165_I 1.031 0.94
38_K 324_E 1.029 0.94
209_F 214_R 1.026 0.94
62_V 65_G 1.024 0.93
31_D 320_L 1.023 0.93
226_I 309_V 1.021 0.93
80_G 170_L 1.02 0.93
208_N 212_S 1.015 0.93
322_S 325_L 1.011 0.93
174_L 204_L 1.009 0.93
177_A 205_Y 1.009 0.93
172_S 201_A 1.006 0.93
68_A 106_I 1.004 0.93
323_F 327_M 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1lucA10.97911000.189Contact Map0.669
1lucB10.93131000.21Contact Map0.65
2i7gA20.95521000.217Contact Map0.745
2wgkA20.96421000.225Contact Map0.707
1ezwA10.93131000.255Contact Map0.689
3raoA20.96421000.257Contact Map0.74
1rhcA10.92241000.258Contact Map0.645
3c8nA40.94031000.259Contact Map0.663
1z69A40.91641000.259Contact Map0.698
3b9oA20.95521000.266Contact Map0.756
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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