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OPENSEQ.org

YECD - Isochorismatase family protein YecD
UniProt: P0ADI7 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12378
Length: 188 (186)
Sequences: 5290
Seq/Len: 28.44

YECD
Paralog alert: 0.71 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: PNCA RUTB YCAC YECD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
113_E 117_R 3.38 1.00
113_E 147_F 3.191 1.00
123_T 148_N 3.183 1.00
105_G 141_N 3.165 1.00
55_R 100_I 2.952 1.00
40_L 152_A 2.681 1.00
126_L 139_A 2.679 1.00
44_F 49_Q 2.538 1.00
16_L 37_A 2.482 1.00
8_T 122_D 2.371 1.00
37_A 127_C 2.339 1.00
152_A 184_I 2.237 1.00
123_T 150_V 2.233 1.00
124_I 142_A 2.065 1.00
113_E 145_L 2.054 1.00
10_A 121_I 2.016 1.00
106_A 138_T 1.977 1.00
171_I 176_A 1.974 1.00
180_S 183_E 1.901 1.00
9_T 123_T 1.901 1.00
29_T 32_E 1.891 1.00
161_A 165_N 1.863 1.00
36_R 39_K 1.831 1.00
136_E 140_R 1.797 1.00
13_V 41_A 1.781 1.00
131_T 164_H 1.765 1.00
153_E 178_V 1.761 1.00
44_F 125_V 1.759 1.00
99_I 115_Q 1.748 1.00
36_R 155_A 1.728 1.00
111_D 115_Q 1.694 1.00
131_T 156_C 1.683 1.00
142_A 149_L 1.663 1.00
126_L 138_T 1.656 1.00
52_F 115_Q 1.633 1.00
39_K 182_E 1.598 1.00
169_N 172_Y 1.572 1.00
43_K 185_L 1.561 1.00
154_D 181_V 1.556 1.00
43_K 47_S 1.548 1.00
45_R 96_D 1.539 1.00
36_R 181_V 1.508 1.00
21_L 87_P 1.504 1.00
132_N 158_A 1.487 1.00
38_G 89_A 1.484 1.00
9_T 125_V 1.468 1.00
13_V 127_C 1.446 1.00
67_K 76_A 1.44 1.00
153_E 180_S 1.43 1.00
125_V 152_A 1.425 1.00
12_V 126_L 1.413 1.00
38_G 42_A 1.413 1.00
153_E 168_I 1.399 0.99
117_R 147_F 1.399 0.99
19_G 84_W 1.376 0.99
13_V 37_A 1.369 0.99
11_L 44_F 1.355 0.99
131_T 168_I 1.344 0.99
18_E 88_A 1.329 0.99
165_N 169_N 1.316 0.99
155_A 181_V 1.315 0.99
97_I 115_Q 1.308 0.99
36_R 154_D 1.3 0.99
107_F 142_A 1.288 0.99
115_Q 119_R 1.275 0.99
135_V 151_I 1.274 0.99
114_L 118_R 1.256 0.99
136_E 170_H 1.236 0.98
50_P 119_R 1.229 0.98
136_E 167_S 1.225 0.98
139_A 171_I 1.203 0.98
33_V 37_A 1.18 0.98
158_A 164_H 1.175 0.98
152_A 155_A 1.156 0.97
54_V 106_A 1.155 0.97
14_I 134_G 1.147 0.97
35_N 89_A 1.126 0.97
151_I 156_C 1.126 0.97
111_D 114_L 1.115 0.96
156_C 164_H 1.107 0.96
139_A 176_A 1.098 0.96
143_W 176_A 1.097 0.96
18_E 85_Q 1.091 0.96
41_A 53_L 1.056 0.95
162_E 165_N 1.05 0.94
15_D 101_K 1.046 0.94
34_V 87_P 1.044 0.94
137_S 140_R 1.022 0.93
10_A 52_F 1.02 0.93
150_V 179_R 1.017 0.93
42_A 46_A 1.009 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1j2rA411000.102Contact Map0.85
3txyA10.99471000.112Contact Map0.794
3hb7A80.95741000.121Contact Map0.889
3irvA111000.13Contact Map0.849
2fq1A20.98941000.134Contact Map0.846
3kl2A1211000.137Contact Map0.847
3ot4A811000.142Contact Map0.87
3hu5A211000.142Contact Map0.845
1nbaA411000.147Contact Map0.9
1nf9A10.97341000.151Contact Map0.8

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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