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OPENSEQ.org

ILVN - Acetolactate synthase isozyme 1 small subunit
UniProt: P0ADF8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10502
Length: 96 (87)
Sequences: 1071
Seq/Len: 12.31

ILVN
Paralog alert: 0.28 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ILVH ILVN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
41_C 50_S 3.41 1.00
17_N 48_D 2.598 1.00
17_N 50_S 2.197 1.00
49_K 76_V 2.166 1.00
37_E 57_N 1.945 1.00
15_V 21_V 1.875 1.00
22_M 39_I 1.788 1.00
7_D 93_V 1.713 1.00
68_Q 71_K 1.685 1.00
31_R 56_V 1.665 1.00
22_M 41_C 1.477 1.00
21_V 52_I 1.46 1.00
17_N 43_P 1.454 1.00
67_S 70_D 1.408 1.00
63_E 67_S 1.406 0.99
70_D 77_K 1.398 0.99
44_I 47_S 1.382 0.99
9_V 80_R 1.361 0.99
16_R 76_V 1.355 0.99
16_R 74_D 1.347 0.99
38_G 55_L 1.344 0.99
82_Q 85_P 1.324 0.99
18_H 74_D 1.3 0.99
56_V 65_M 1.297 0.99
11_L 78_V 1.296 0.99
28_L 64_Q 1.25 0.99
22_M 36_V 1.246 0.98
64_Q 68_Q 1.244 0.98
13_L 38_G 1.199 0.98
8_N 88_F 1.195 0.98
32_R 71_K 1.156 0.97
12_E 81_N 1.153 0.97
45_Q 51_H 1.142 0.97
25_V 52_I 1.131 0.97
27_G 75_V 1.119 0.96
15_V 52_I 1.098 0.96
17_N 46_D 1.074 0.95
47_S 59_D 1.067 0.95
24_H 72_L 1.063 0.95
8_N 37_E 1.058 0.95
35_N 41_C 1.045 0.94
31_R 55_L 1.042 0.94
49_K 77_K 1.034 0.94
39_I 50_S 1.026 0.94
63_E 77_K 1.018 0.93
21_V 31_R 1.006 0.93
33_A 58_D 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2f1fA20.947999.90.351Contact Map0.652
2pc6A40.958399.90.362Contact Map0.606
2fgcA10.989699.90.375Contact Map0.512
2lvwA20.989699.60.553Contact Map0.412
1y7pA30.9479990.678Contact Map0.597
1zpvA30.927198.40.734Contact Map0.376
2f06A20.947998.40.739Contact Map0.228
2ko1A20.895898.30.745Contact Map0.533
1u8sA20.958398.20.754Contact Map0.397
3n0vA40.968897.90.768Contact Map0.55

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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