May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
LOLC - Lipoprotein-releasing system transmembrane protein LolC
UniProt: P0ADC3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13439
Length: 399 (384)
Sequences: 11019
Seq/Len: 28.70
LOLC
Paralog alert: 0.88 [within 20: 0.41] - ratio of genomes with paralogs
Cluster includes: LOLC LOLE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
148_E 191_A 3.743 1.00
148_E 152_S 3.433 1.00
161_Q 185_N 3.42 1.00
144_V 201_M 3.257 1.00
133_K 187_I 3.093 1.00
391_Q 394_E 2.89 1.00
297_V 314_F 2.884 1.00
145_I 188_G 2.837 1.00
161_Q 183_L 2.782 1.00
143_N 187_I 2.566 1.00
91_N 227_D 2.558 1.00
301_Q 307_P 2.552 1.00
128_Y 191_A 2.535 1.00
146_L 186_V 2.46 1.00
89_G 227_D 2.419 1.00
151_A 189_T 2.406 1.00
146_L 150_L 2.376 1.00
203_V 208_A 2.348 1.00
163_R 183_L 2.278 1.00
144_V 203_V 2.219 1.00
385_W 389_A 2.201 1.00
381_L 385_W 2.192 1.00
326_A 369_A 2.184 1.00
231_K 234_S 2.17 1.00
318_G 380_T 2.166 1.00
143_N 185_N 2.164 1.00
82_E 85_V 2.156 1.00
144_V 162_I 2.155 1.00
146_L 201_M 2.139 1.00
91_N 225_W 2.132 1.00
89_G 238_Q 2.094 1.00
306_T 309_Q 2.094 1.00
81_P 85_V 2.073 1.00
335_L 339_Q 2.043 1.00
35_T 328_L 2.031 1.00
157_N 160_D 1.971 1.00
146_L 151_A 1.961 1.00
144_V 184_F 1.86 1.00
184_F 207_D 1.852 1.00
293_K 317_Q 1.836 1.00
322_G 376_A 1.836 1.00
31_T 35_T 1.813 1.00
147_G 190_F 1.804 1.00
134_Q 145_I 1.8 1.00
226_L 235_L 1.8 1.00
308_R 312_M 1.764 1.00
311_M 385_W 1.754 1.00
366_I 370_L 1.731 1.00
145_I 190_F 1.727 1.00
361_E 364_Q 1.724 1.00
83_T 86_K 1.71 1.00
293_K 296_E 1.692 1.00
325_G 329_G 1.692 1.00
228_E 231_K 1.674 1.00
89_G 235_L 1.656 1.00
129_L 188_G 1.648 1.00
39_M 332_L 1.64 1.00
236_S 248_D 1.621 1.00
233_D 236_S 1.62 1.00
149_Q 152_S 1.614 1.00
146_L 162_I 1.609 1.00
294_Q 395_A 1.583 1.00
147_G 150_L 1.576 1.00
149_Q 192_A 1.566 1.00
362_P 366_I 1.555 1.00
90_V 93_V 1.552 1.00
15_R 18_A 1.55 1.00
101_V 114_M 1.544 1.00
92_R 225_W 1.541 1.00
158_R 189_T 1.538 1.00
297_V 310_I 1.533 1.00
133_K 143_N 1.533 1.00
122_K 134_Q 1.53 1.00
120_A 123_D 1.525 1.00
298_A 395_A 1.512 1.00
234_S 238_Q 1.498 1.00
145_I 187_I 1.488 1.00
81_P 93_V 1.488 1.00
326_A 372_A 1.473 1.00
34_I 325_G 1.469 1.00
116_G 208_A 1.469 1.00
140_G 143_N 1.467 1.00
130_V 148_E 1.457 1.00
150_L 154_L 1.456 1.00
265_N 269_L 1.45 1.00
96_I 221_G 1.448 1.00
156_V 186_V 1.431 1.00
90_V 224_L 1.427 1.00
307_P 388_A 1.427 1.00
205_I 209_S 1.425 1.00
135_T 145_I 1.42 1.00
130_V 191_A 1.416 1.00
53_R 57_N 1.413 1.00
329_G 333_G 1.395 0.99
206_E 209_S 1.386 0.99
10_G 316_V 1.381 0.99
384_S 388_A 1.381 0.99
367_V 370_L 1.376 0.99
232_V 236_S 1.373 0.99
14_M 27_S 1.368 0.99
279_A 379_S 1.351 0.99
117_I 121_Q 1.345 0.99
35_T 332_L 1.345 0.99
135_T 187_I 1.34 0.99
93_V 224_L 1.328 0.99
142_Y 207_D 1.3 0.99
204_N 207_D 1.299 0.99
97_T 208_A 1.294 0.99
248_D 251_D 1.292 0.99
27_S 321_A 1.291 0.99
87_L 238_Q 1.291 0.99
131_N 157_N 1.288 0.99
28_W 32_I 1.287 0.99
158_R 187_I 1.286 0.99
360_I 365_V 1.285 0.99
38_V 329_G 1.264 0.99
39_M 336_L 1.262 0.99
93_V 222_W 1.261 0.99
335_L 338_S 1.26 0.99
49_N 361_E 1.255 0.99
333_G 337_A 1.235 0.98
129_L 134_Q 1.231 0.98
84_A 93_V 1.226 0.98
233_D 237_Q 1.224 0.98
131_N 158_R 1.219 0.98
12_R 15_R 1.216 0.98
17_R 20_D 1.215 0.98
103_L 112_G 1.215 0.98
235_L 238_Q 1.214 0.98
322_G 326_A 1.211 0.98
385_W 388_A 1.21 0.98
363_L 367_V 1.209 0.98
156_V 160_D 1.207 0.98
268_G 272_S 1.205 0.98
42_V 333_G 1.198 0.98
87_L 235_L 1.197 0.98
13_Y 317_Q 1.187 0.98
328_L 331_A 1.184 0.98
133_K 136_D 1.181 0.98
11_L 15_R 1.18 0.98
43_T 336_L 1.175 0.98
300_L 313_V 1.173 0.98
78_Q 82_E 1.169 0.97
382_Y 385_W 1.168 0.97
331_A 335_L 1.167 0.97
46_S 50_G 1.158 0.97
370_L 374_A 1.155 0.97
19_A 28_W 1.155 0.97
384_S 387_A 1.139 0.97
84_A 224_L 1.125 0.97
230_L 235_L 1.123 0.97
92_R 124_P 1.116 0.96
164_V 184_F 1.115 0.96
39_M 333_G 1.113 0.96
114_M 203_V 1.103 0.96
53_R 359_A 1.099 0.96
327_I 331_A 1.093 0.96
31_T 325_G 1.088 0.96
226_L 232_V 1.087 0.96
112_G 201_M 1.082 0.96
250_R 254_G 1.081 0.95
359_A 362_P 1.078 0.95
227_D 231_K 1.076 0.95
35_T 39_M 1.076 0.95
309_Q 312_M 1.072 0.95
66_A 236_S 1.065 0.95
286_L 318_G 1.064 0.95
379_S 383_P 1.064 0.95
144_V 186_V 1.058 0.95
49_N 52_E 1.057 0.95
298_A 302_T 1.057 0.95
105_S 160_D 1.055 0.95
31_T 328_L 1.053 0.95
94_A 117_I 1.051 0.94
49_N 53_R 1.048 0.94
307_P 389_A 1.046 0.94
132_V 188_G 1.044 0.94
386_R 389_A 1.036 0.94
145_I 202_L 1.035 0.94
95_P 118_D 1.033 0.94
205_I 219_I 1.032 0.94
142_Y 182_R 1.03 0.94
294_Q 298_A 1.03 0.94
339_Q 343_L 1.029 0.94
236_S 246_W 1.028 0.94
143_N 204_N 1.027 0.94
112_G 150_L 1.023 0.93
289_M 293_K 1.022 0.93
42_V 368_I 1.02 0.93
117_I 202_L 1.02 0.93
20_D 292_E 1.019 0.93
305_L 309_Q 1.019 0.93
110_A 153_Q 1.016 0.93
97_T 209_S 1.013 0.93
135_T 143_N 1.012 0.93
319_A 377_L 1.006 0.93
9_I 313_V 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ftjA10.493799.30.775Contact Map0.847
3is6A20.501398.70.822Contact Map0.751
2kogA10.10289.60.958Contact Map0.406
1yfbA20.14795.50.962Contact Map0.596
3hd7A20.10284.50.964Contact Map0.649
2m8rA10.11033.80.965Contact Map0.256
3hd7B20.11033.80.965Contact Map0.604
2f95B10.23063.50.966Contact Map0.402
4eneA20.24313.40.966Contact Map0.176
2l66A20.13283.20.967Contact Map0.56
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 2.3243 seconds.