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OPENSEQ.org
TESA - Acyl-CoA thioesterase I
UniProt: P0ADA1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11542
Length: 208 (179)
Sequences: 3190
Seq/Len: 17.82
TESA
Paralog alert: 0.39 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
115_R 157_E 3.316 1.00
111_E 153_K 3.218 1.00
76_G 96_L 2.967 1.00
115_R 158_F 2.932 1.00
81_P 120_D 2.882 1.00
73_S 113_T 2.817 1.00
92_V 121_V 2.81 1.00
132_Q 162_L 2.681 1.00
71_D 79_R 2.63 1.00
32_I 38_S 2.615 1.00
119_Q 158_F 2.469 1.00
190_P 194_D 2.023 1.00
38_S 67_S 1.967 1.00
122_K 158_F 1.964 1.00
30_L 93_L 1.911 1.00
130_L 155_A 1.91 1.00
115_R 119_Q 1.91 1.00
77_L 116_Q 1.823 1.00
29_T 62_S 1.809 1.00
33_L 76_G 1.78 1.00
56_K 197_A 1.77 1.00
94_V 117_I 1.68 1.00
114_L 151_Y 1.65 1.00
92_V 126_A 1.626 1.00
184_P 192_I 1.6 1.00
118_L 160_V 1.565 1.00
165_F 192_I 1.549 1.00
73_S 110_T 1.544 1.00
44_S 186_R 1.521 1.00
71_D 75_Q 1.488 1.00
133_I 148_S 1.482 1.00
152_P 162_L 1.469 1.00
187_D 190_P 1.464 1.00
37_L 184_P 1.446 1.00
132_Q 164_P 1.434 1.00
99_N 183_H 1.432 1.00
52_L 190_P 1.415 1.00
118_L 154_L 1.413 1.00
56_K 194_D 1.359 0.99
195_W 198_K 1.355 0.99
98_G 182_I 1.355 0.99
111_E 150_I 1.348 0.99
193_A 197_A 1.347 0.99
41_Y 69_S 1.342 0.99
127_E 161_P 1.338 0.99
180_D 183_H 1.334 0.99
80_L 121_V 1.332 0.99
118_L 130_L 1.32 0.99
77_L 113_T 1.304 0.99
39_A 69_S 1.294 0.99
28_D 90_R 1.288 0.99
101_G 110_T 1.267 0.99
163_L 199_Q 1.254 0.99
106_Q 109_Q 1.252 0.99
36_S 183_H 1.239 0.98
80_L 117_I 1.227 0.98
107_P 150_I 1.224 0.98
155_A 162_L 1.22 0.98
134_R 148_S 1.217 0.98
110_T 147_F 1.195 0.98
79_R 83_L 1.183 0.98
31_L 89_P 1.161 0.97
199_Q 202_P 1.159 0.97
176_W 191_F 1.15 0.97
91_W 129_L 1.15 0.97
73_S 114_L 1.142 0.97
32_I 93_L 1.133 0.97
74_Q 109_Q 1.127 0.97
118_L 158_F 1.125 0.97
52_L 193_A 1.113 0.96
154_L 158_F 1.096 0.96
113_T 117_I 1.077 0.95
40_G 48_A 1.077 0.95
129_L 163_L 1.076 0.95
191_F 194_D 1.074 0.95
150_I 153_K 1.068 0.95
130_L 154_L 1.056 0.95
47_A 186_R 1.047 0.94
116_Q 120_D 1.047 0.94
93_L 129_L 1.039 0.94
115_R 154_L 1.025 0.93
53_L 197_A 1.023 0.93
153_K 157_E 1.017 0.93
73_S 77_L 1.017 0.93
32_I 53_L 1.013 0.93
164_P 167_M 1.012 0.93
110_T 151_Y 1.008 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3hp4A10.8751000.398Contact Map0.782
4jggA20.97121000.405Contact Map0.827
1ivnA10.8751000.424Contact Map0.832
3rjtA20.8751000.441Contact Map0.846
1yzfA10.8511000.446Contact Map0.779
2q0qA80.83651000.446Contact Map0.772
3milA20.87021000.447Contact Map0.858
2o14A10.99041000.447Contact Map0.846
1k7cA10.84621000.455Contact Map0.743
4iyjA20.90871000.462Contact Map0.729
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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