May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
LIVJ - Leu/Ile/Val-binding protein
UniProt: P0AD96 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10539
Length: 367 (344)
Sequences: 7646
Seq/Len: 22.23
LIVJ
Paralog alert: 0.68 [within 20: 0.28] - ratio of genomes with paralogs
Cluster includes: LIVJ LIVK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
27_K 68_Q 3.687 1.00
25_D 68_Q 3.565 1.00
54_A 291_K 3.485 1.00
182_Q 195_F 3.268 1.00
312_A 315_N 3.035 1.00
163_R 191_N 3.002 1.00
25_D 65_N 2.866 1.00
46_F 50_E 2.77 1.00
56_I 311_Q 2.764 1.00
72_Y 87_K 2.74 1.00
81_A 104_S 2.715 1.00
95_Y 310_L 2.705 1.00
116_G 136_L 2.693 1.00
283_P 287_A 2.644 1.00
286_D 290_A 2.63 1.00
196_D 211_R 2.628 1.00
185_L 190_A 2.604 1.00
54_A 58_A 2.578 1.00
75_A 80_Q 2.531 1.00
55_D 287_A 2.437 1.00
312_A 316_Q 2.428 1.00
282_K 286_D 2.33 1.00
96_V 112_Y 2.282 1.00
29_A 88_V 2.221 1.00
333_D 338_P 2.194 1.00
319_D 322_E 2.172 1.00
289_K 295_P 2.165 1.00
331_S 338_P 2.152 1.00
182_Q 186_K 2.147 1.00
358_H 364_T 2.129 1.00
25_D 66_K 2.09 1.00
53_V 307_L 1.99 1.00
50_E 54_A 1.974 1.00
311_Q 315_N 1.964 1.00
31_V 74_D 1.944 1.00
162_Q 218_D 1.932 1.00
156_L 188_G 1.878 1.00
76_C 101_C 1.864 1.00
322_E 325_K 1.842 1.00
307_L 311_Q 1.827 1.00
72_Y 84_V 1.827 1.00
53_V 69_I 1.812 1.00
153_K 157_E 1.789 1.00
31_V 84_V 1.789 1.00
55_D 304_Y 1.781 1.00
326_Y 329_A 1.775 1.00
116_G 321_A 1.771 1.00
165_A 194_F 1.737 1.00
153_K 188_G 1.69 1.00
55_D 308_Q 1.672 1.00
312_A 330_N 1.657 1.00
328_K 345_G 1.65 1.00
331_S 340_T 1.643 1.00
305_A 334_T 1.625 1.00
179_R 183_D 1.623 1.00
184_G 187_K 1.593 1.00
168_H 197_G 1.563 1.00
55_D 59_K 1.523 1.00
186_K 191_N 1.522 1.00
56_I 308_Q 1.517 1.00
155_I 246_M 1.516 1.00
283_P 286_D 1.512 1.00
49_A 307_L 1.506 1.00
255_S 258_N 1.504 1.00
77_D 80_Q 1.499 1.00
209_V 239_A 1.496 1.00
138_L 328_K 1.496 1.00
183_D 187_K 1.491 1.00
324_A 328_K 1.483 1.00
321_A 325_K 1.48 1.00
148_G 152_A 1.473 1.00
67_L 311_Q 1.459 1.00
316_Q 326_Y 1.454 1.00
89_V 117_I 1.431 1.00
87_K 91_D 1.42 1.00
27_K 70_V 1.416 1.00
161_P 219_F 1.415 1.00
235_Q 238_A 1.392 0.99
47_T 50_E 1.39 0.99
85_A 112_Y 1.389 0.99
163_R 216_N 1.385 0.99
47_T 288_I 1.384 0.99
165_A 196_D 1.381 0.99
325_K 329_A 1.379 0.99
30_V 49_A 1.358 0.99
260_A 264_A 1.356 0.99
99_H 108_A 1.354 0.99
52_A 311_Q 1.351 0.99
48_G 303_T 1.344 0.99
236_A 241_L 1.344 0.99
284_I 300_V 1.338 0.99
164_I 219_F 1.333 0.99
139_R 346_D 1.332 0.99
125_T 144_D 1.331 0.99
52_A 307_L 1.32 0.99
33_A 74_D 1.32 0.99
201_G 228_E 1.316 0.99
120_I 310_L 1.312 0.99
99_H 105_T 1.31 0.99
138_L 324_A 1.294 0.99
287_A 290_A 1.286 0.99
57_N 61_G 1.281 0.99
47_T 292_K 1.281 0.99
118_L 320_P 1.279 0.99
209_V 236_A 1.273 0.99
317_S 326_Y 1.27 0.99
110_D 114_D 1.264 0.99
161_P 218_D 1.261 0.99
170_K 175_E 1.256 0.99
209_V 235_Q 1.244 0.98
46_F 71_K 1.24 0.98
198_I 224_G 1.239 0.98
170_K 199_T 1.213 0.98
310_L 314_L 1.211 0.98
113_E 135_Q 1.208 0.98
277_Q 282_K 1.206 0.98
49_A 69_I 1.202 0.98
80_Q 84_V 1.201 0.98
163_R 193_V 1.199 0.98
24_E 65_N 1.192 0.98
30_V 53_V 1.187 0.98
149_P 184_G 1.185 0.98
175_E 197_G 1.183 0.98
202_E 208_L 1.18 0.98
80_Q 83_A 1.174 0.98
247_G 251_V 1.172 0.98
314_L 323_I 1.169 0.97
102_S 126_A 1.164 0.97
157_E 188_G 1.162 0.97
309_S 327_L 1.158 0.97
86_N 90_N 1.151 0.97
50_E 71_K 1.15 0.97
136_L 324_A 1.146 0.97
210_A 214_K 1.143 0.97
72_Y 91_D 1.141 0.97
90_N 115_E 1.137 0.97
56_I 307_L 1.127 0.97
56_I 67_L 1.117 0.96
180_A 183_D 1.104 0.96
43_D 47_T 1.104 0.96
85_A 96_V 1.1 0.96
29_A 93_I 1.098 0.96
280_A 333_D 1.095 0.96
156_L 190_A 1.093 0.96
211_R 215_E 1.093 0.96
286_D 289_K 1.09 0.96
165_A 217_I 1.087 0.96
163_R 218_D 1.085 0.96
48_G 300_V 1.085 0.96
72_Y 88_V 1.085 0.96
213_K 241_L 1.082 0.96
305_A 336_M 1.08 0.95
156_L 162_Q 1.073 0.95
167_V 208_L 1.071 0.95
70_V 91_D 1.07 0.95
89_V 111_I 1.07 0.95
63_K 315_N 1.068 0.95
165_A 193_V 1.063 0.95
49_A 97_I 1.062 0.95
47_T 294_D 1.056 0.95
99_H 119_M 1.053 0.95
308_Q 311_Q 1.051 0.94
236_A 245_F 1.05 0.94
35_S 73_D 1.05 0.94
52_A 304_Y 1.046 0.94
175_E 179_R 1.037 0.94
135_Q 324_A 1.034 0.94
105_T 124_A 1.034 0.94
316_Q 330_N 1.029 0.94
31_V 108_A 1.029 0.94
112_Y 119_M 1.029 0.94
74_D 104_S 1.021 0.93
85_A 89_V 1.021 0.93
45_E 303_T 1.021 0.93
127_P 145_S 1.016 0.93
209_V 241_L 1.015 0.93
51_Q 55_D 1.012 0.93
171_Q 174_G 1.011 0.93
184_G 188_G 1.01 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4n0qA40.92921000.208Contact Map0.741
3hutA10.92641000.221Contact Map0.691
1usgA10.93461000.222Contact Map0.733
4gnrA10.91281000.223Contact Map0.734
3ipcA10.93461000.229Contact Map0.696
3h5lA20.94551000.232Contact Map0.671
4f11A10.9211000.239Contact Map0.682
3lkbA20.93731000.239Contact Map0.668
3td9A10.91551000.246Contact Map0.74
3lopA10.92371000.247Contact Map0.719
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 1.0174 seconds.