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OPENSEQ.org
YOHK - Inner membrane protein YohK
UniProt: P0AD19 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12024
Length: 231 (222)
Sequences: 845
Seq/Len: 3.81
YOHK
Paralog alert: 0.31 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
132_I 212_G 4.142 1.00
133_A 151_V 3.918 1.00
135_A 138_G 3.222 1.00
137_G 147_S 3.003 1.00
12_T 55_Y 2.523 1.00
162_G 181_M 2.434 1.00
174_K 197_D 2.42 1.00
15_V 40_V 2.317 1.00
125_P 137_G 1.963 1.00
128_V 136_V 1.903 1.00
192_R 195_E 1.857 1.00
181_M 193_C 1.852 1.00
158_G 185_S 1.841 1.00
70_V 154_V 1.778 0.99
15_V 37_A 1.762 0.99
44_F 48_T 1.748 0.99
206_L 212_G 1.699 0.99
19_A 37_A 1.698 0.99
167_N 177_R 1.672 0.99
121_A 140_I 1.659 0.99
162_G 166_L 1.65 0.99
15_V 19_A 1.649 0.99
190_T 204_S 1.633 0.99
110_A 120_A 1.598 0.98
36_V 40_V 1.574 0.98
56_F 63_N 1.562 0.98
197_D 200_E 1.544 0.98
126_K 154_V 1.451 0.97
19_A 36_V 1.426 0.96
18_A 22_L 1.423 0.96
144_P 148_A 1.412 0.96
31_L 36_V 1.409 0.96
100_V 104_V 1.405 0.96
134_M 144_P 1.399 0.95
166_L 181_M 1.392 0.95
122_S 143_I 1.368 0.95
48_T 51_S 1.365 0.95
125_P 147_S 1.349 0.94
166_L 171_I 1.334 0.94
208_L 212_G 1.316 0.93
14_I 100_V 1.315 0.93
43_P 46_M 1.303 0.93
131_P 135_A 1.272 0.91
156_I 188_L 1.27 0.91
103_M 124_L 1.265 0.91
177_R 200_E 1.263 0.91
22_L 36_V 1.263 0.91
108_S 112_L 1.262 0.91
106_G 154_V 1.259 0.91
98_G 183_T 1.254 0.91
127_S 154_V 1.245 0.90
99_S 211_C 1.218 0.89
66_L 187_A 1.207 0.88
77_L 220_P 1.201 0.88
79_E 198_Y 1.2 0.88
110_A 123_I 1.188 0.87
11_L 41_I 1.186 0.87
58_G 125_P 1.173 0.86
56_F 59_S 1.171 0.86
103_M 219_A 1.164 0.86
96_F 214_I 1.159 0.86
87_R 203_F 1.157 0.85
37_A 40_V 1.156 0.85
107_T 124_L 1.155 0.85
97_I 101_V 1.152 0.85
51_S 54_S 1.15 0.85
204_S 207_A 1.15 0.85
108_S 111_L 1.146 0.85
70_V 75_Y 1.145 0.85
179_L 207_A 1.139 0.84
15_V 44_F 1.138 0.84
188_L 207_A 1.138 0.84
66_L 131_P 1.12 0.83
99_S 103_M 1.116 0.82
188_L 191_A 1.11 0.82
43_P 47_L 1.103 0.81
186_H 189_G 1.099 0.81
205_S 209_V 1.095 0.81
159_A 188_L 1.085 0.80
110_A 115_A 1.082 0.80
94_I 203_F 1.081 0.80
147_S 151_V 1.07 0.79
67_Q 131_P 1.068 0.78
42_I 152_I 1.064 0.78
183_T 205_S 1.064 0.78
129_T 132_I 1.057 0.77
104_V 108_S 1.057 0.77
21_K 161_F 1.051 0.77
202_A 206_L 1.05 0.77
15_V 41_I 1.046 0.76
207_A 216_S 1.043 0.76
105_T 109_V 1.041 0.76
46_M 49_G 1.034 0.75
80_Q 134_M 1.029 0.75
14_I 171_I 1.022 0.74
18_A 21_K 1.022 0.74
203_F 208_L 1.022 0.74
11_L 44_F 1.021 0.74
84_I 213_I 1.021 0.74
22_L 31_L 1.02 0.74
122_S 142_G 1.019 0.74
45_L 51_S 1.017 0.74
179_L 183_T 1.013 0.73
14_I 18_A 1.01 0.73
149_V 177_R 1.005 0.72
77_L 129_T 1.004 0.72
20_R 24_A 1.003 0.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3zuxA10.761993.60.923Contact Map0.363
2a65A10.389621.70.959Contact Map0.273
4bwzA10.844218.60.961Contact Map0.369
2zy9A20.77499.20.966Contact Map0.183
4humA10.67976.80.968Contact Map0.187
4lz6A10.69266.70.968Contact Map0.262
3nd0A20.92645.10.969Contact Map0.116
3w4tA10.70134.80.97Contact Map0.264
3ne5A10.52813.80.971Contact Map0.259
3aqpA20.55843.70.971Contact Map0.363
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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