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OPENSEQ.org

YDJA - Putative NAD(P)H nitroreductase YdjA
UniProt: P0ACY1 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11134
Length: 183 (182)
Sequences: 5963
Seq/Len: 32.76

YDJA
Paralog alert: 0.81 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: NFNB RUTE YDJA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
22_T 25_Q 4.362 1.00
28_N 125_Q 3.618 1.00
23_G 51_E 3.047 1.00
47_F 114_A 2.814 1.00
23_G 27_Q 2.796 1.00
29_I 122_A 2.68 1.00
19_P 162_T 2.599 1.00
128_G 163_P 2.562 1.00
119_Q 129_G 2.407 1.00
9_N 123_V 2.392 1.00
31_R 34_M 2.343 1.00
127_F 162_T 2.278 1.00
47_F 90_I 2.161 1.00
48_F 93_V 2.143 1.00
25_Q 125_Q 2.106 1.00
33_G 118_M 2.053 1.00
25_Q 127_F 2.046 1.00
5_E 9_N 1.9 1.00
93_V 152_D 1.867 1.00
143_R 154_I 1.815 1.00
127_F 160_L 1.81 1.00
53_E 56_E 1.785 1.00
46_H 181_T 1.767 1.00
115_V 156_G 1.766 1.00
57_R 145_A 1.757 1.00
122_A 160_L 1.718 1.00
32_A 121_A 1.709 1.00
3_A 7_L 1.7 1.00
90_I 118_M 1.692 1.00
115_V 158_L 1.656 1.00
17_A 164_Q 1.651 1.00
174_P 178_P 1.579 1.00
3_A 6_L 1.57 1.00
15_R 164_Q 1.566 1.00
30_L 180_V 1.557 1.00
25_Q 162_T 1.529 1.00
29_I 118_M 1.514 1.00
109_M 112_G 1.457 1.00
29_I 160_L 1.451 1.00
113_C 116_M 1.425 1.00
131_W 156_G 1.42 1.00
16_L 159_Y 1.412 1.00
54_G 57_R 1.399 0.99
56_E 84_F 1.37 0.99
92_V 115_V 1.368 0.99
29_I 127_F 1.363 0.99
119_Q 158_L 1.361 0.99
93_V 148_C 1.36 0.99
25_Q 28_N 1.35 0.99
59_S 84_F 1.349 0.99
91_T 157_F 1.33 0.99
123_V 128_G 1.311 0.99
119_Q 131_W 1.3 0.99
8_I 31_R 1.297 0.99
56_E 60_A 1.289 0.99
91_T 154_I 1.28 0.99
22_T 162_T 1.279 0.99
2_D 5_E 1.278 0.99
36_A 117_A 1.277 0.99
176_P 180_V 1.276 0.99
51_E 88_L 1.266 0.99
21_P 127_F 1.24 0.98
95_K 151_Q 1.24 0.98
27_Q 177_T 1.237 0.98
49_V 88_L 1.23 0.98
122_A 129_G 1.227 0.98
20_A 51_E 1.221 0.98
111_A 155_V 1.217 0.98
46_H 152_D 1.212 0.98
32_A 125_Q 1.199 0.98
5_E 8_I 1.198 0.98
8_I 35_R 1.182 0.98
27_Q 31_R 1.177 0.98
4_L 28_N 1.176 0.98
96_C 153_K 1.175 0.98
47_F 92_V 1.168 0.97
61_V 145_A 1.159 0.97
88_L 160_L 1.149 0.97
26_L 88_L 1.147 0.97
121_A 124_A 1.141 0.97
12_S 130_I 1.139 0.97
58_F 142_V 1.13 0.97
7_L 120_M 1.127 0.97
90_I 160_L 1.126 0.97
38_D 45_W 1.097 0.96
121_A 125_Q 1.092 0.96
17_A 162_T 1.075 0.95
92_V 118_M 1.068 0.95
57_R 60_A 1.067 0.95
116_M 120_M 1.053 0.95
94_A 107_Q 1.046 0.94
49_V 180_V 1.04 0.94
21_P 25_Q 1.04 0.94
6_L 124_A 1.037 0.94
94_A 111_A 1.029 0.94
109_M 133_S 1.027 0.94
129_G 160_L 1.019 0.93
112_G 131_W 1.018 0.93
141_V 144_E 1.008 0.93
92_V 111_A 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bm1A211000.104Contact Map0.771
3k6hA20.99451000.119Contact Map0.718
3bemA20.90161000.124Contact Map0.847
1icrA20.9291000.126Contact Map0.801
3of4A30.90161000.129Contact Map0.802
2b67A40.90161000.131Contact Map0.845
1bkjA20.91261000.133Contact Map0.763
3gagA40.89621000.134Contact Map0.844
1zchA10.91261000.135Contact Map0.753
2i7hA60.98361000.135Contact Map0.871

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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