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OPENSEQ.org
RPIR - HTH-type transcriptional regulator RpiR
UniProt: P0ACS7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12459
Length: 296 (277)
Sequences: 2637
Seq/Len: 9.52
RPIR
Paralog alert: 0.77 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: HEXR MURR RPIR YFHH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
220_C 233_A 3.694 1.00
134_A 219_I 3.435 1.00
142_R 189_G 3.38 1.00
200_R 228_P 3.168 1.00
194_V 208_V 3.117 1.00
134_A 235_Y 3.114 1.00
212_K 234_D 2.863 1.00
24_Q 36_E 2.779 1.00
73_F 82_A 2.775 1.00
159_V 163_F 2.773 1.00
41_P 44_L 2.755 1.00
136_R 271_L 2.714 1.00
208_V 218_I 2.597 1.00
135_A 267_S 2.502 1.00
137_F 217_K 2.478 1.00
191_V 219_I 2.308 1.00
37_W 41_P 2.212 1.00
146_L 159_V 2.163 1.00
35_V 67_V 2.13 1.00
116_L 120_M 2.108 1.00
193_L 221_I 2.084 1.00
68_S 79_L 2.005 1.00
237_I 260_L 1.984 1.00
209_E 232_L 1.957 1.00
142_R 190_D 1.948 1.00
31_E 70_L 1.939 1.00
195_V 221_I 1.93 1.00
208_V 229_I 1.899 1.00
156_C 195_V 1.883 1.00
137_F 235_Y 1.881 1.00
138_F 193_L 1.867 1.00
48_P 56_A 1.863 1.00
159_V 193_L 1.833 1.00
272_N 275_Q 1.812 1.00
211_A 216_A 1.786 1.00
36_E 40_K 1.784 1.00
186_L 216_A 1.767 1.00
24_Q 32_S 1.766 1.00
133_R 235_Y 1.766 1.00
102_E 110_K 1.76 1.00
217_K 234_D 1.732 1.00
146_L 163_F 1.729 1.00
159_V 261_L 1.713 1.00
53_V 76_F 1.674 1.00
137_F 191_V 1.673 1.00
194_V 218_I 1.625 1.00
74_S 78_N 1.623 1.00
127_N 130_E 1.617 1.00
34_I 67_V 1.598 1.00
45_S 83_L 1.593 1.00
214_N 282_K 1.593 1.00
112_F 119_I 1.578 1.00
28_T 70_L 1.57 1.00
138_F 191_V 1.56 1.00
122_G 240_P 1.558 1.00
146_L 156_C 1.555 1.00
65_V 75_G 1.549 1.00
146_L 193_L 1.549 1.00
155_I 261_L 1.543 1.00
220_C 236_I 1.537 1.00
186_L 192_V 1.492 1.00
139_Y 268_V 1.491 1.00
32_S 36_E 1.482 1.00
30_N 63_M 1.481 1.00
53_V 64_I 1.479 1.00
130_E 133_R 1.476 1.00
143_Q 169_R 1.465 1.00
187_Q 190_D 1.458 1.00
44_L 56_A 1.451 1.00
138_F 144_R 1.445 1.00
76_F 80_R 1.421 0.99
73_F 79_L 1.414 0.99
38_L 79_L 1.409 0.99
139_Y 272_N 1.4 0.99
194_V 204_V 1.399 0.99
130_E 134_A 1.391 0.99
157_A 174_P 1.387 0.99
34_I 57_L 1.385 0.99
141_A 191_V 1.376 0.99
195_V 261_L 1.373 0.99
192_V 211_A 1.37 0.99
50_I 65_V 1.368 0.99
144_R 168_V 1.357 0.99
145_D 186_L 1.333 0.99
81_S 84_E 1.324 0.99
109_N 123_Q 1.32 0.99
206_A 209_E 1.302 0.99
50_I 64_I 1.301 0.99
186_L 190_D 1.3 0.99
23_K 26_G 1.285 0.99
146_L 170_C 1.281 0.99
34_I 63_M 1.28 0.99
132_H 267_S 1.278 0.99
155_I 195_V 1.27 0.99
139_Y 271_L 1.269 0.99
137_F 219_I 1.267 0.99
115_T 262_D 1.251 0.98
135_A 271_L 1.244 0.98
103_A 106_D 1.243 0.98
192_V 216_A 1.238 0.98
142_R 187_Q 1.235 0.98
130_E 235_Y 1.221 0.98
37_W 48_P 1.215 0.98
117_R 120_M 1.213 0.98
158_D 162_K 1.212 0.98
239_S 257_Q 1.209 0.98
160_Q 170_C 1.207 0.98
218_I 233_A 1.194 0.98
136_R 140_Q 1.191 0.98
143_Q 190_D 1.182 0.97
147_Y 192_V 1.174 0.97
151_G 250_N 1.164 0.97
134_A 264_F 1.163 0.97
196_T 229_I 1.143 0.97
24_Q 35_V 1.14 0.97
33_R 58_A 1.14 0.97
44_L 48_P 1.13 0.96
177_H 203_D 1.126 0.96
20_L 67_V 1.124 0.96
210_L 213_K 1.124 0.96
31_E 34_I 1.112 0.96
67_V 71_L 1.112 0.96
18_P 22_M 1.111 0.96
50_I 54_A 1.107 0.96
158_D 254_R 1.107 0.96
37_W 57_L 1.106 0.96
163_F 268_V 1.106 0.96
168_V 268_V 1.105 0.96
30_N 33_R 1.09 0.95
220_C 229_I 1.084 0.95
189_G 217_K 1.084 0.95
51_K 61_E 1.069 0.95
196_T 199_G 1.06 0.94
239_S 260_L 1.056 0.94
143_Q 171_Q 1.056 0.94
160_Q 172_A 1.054 0.94
141_A 144_R 1.046 0.94
79_L 83_L 1.033 0.93
205_K 220_C 1.029 0.93
77_R 80_R 1.023 0.93
217_K 235_Y 1.018 0.93
30_N 34_I 1.017 0.93
146_L 195_V 1.012 0.92
57_L 62_A 1.008 0.92
250_N 253_A 1.007 0.92
19_Y 23_K 1.006 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ivnA20.93921000.239Contact Map0.844
3shoA40.62841000.573Contact Map0.862
2xhzA40.60811000.599Contact Map0.821
3fxaA40.648699.90.609Contact Map0.856
3etnA40.682499.90.615Contact Map0.763
1m3sA20.591299.90.621Contact Map0.803
1vimA40.645399.90.623Contact Map0.845
3iwfA20.361599.90.628Contact Map0.836
1jeoA10.591299.90.629Contact Map0.751
2o3fA30.371699.90.634Contact Map0.734
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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