OPENSEQ.org - ASNC - ECOLI GREMLIN

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ASNC - Regulatory protein AsnC

UniProt:	P0ACI6	Sequence MENYLIDNLDRGILEALMGNARTAYAELAKQFGVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSAKDYPSALAKLESLDEVTEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLIVLQNPIMRTIKP	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG10093
Length:	152 (147)
Sequences:	5726
Seq/Len:	38.95

ASNC
Paralog alert: 0.82 [within 20: 0.14] - ratio of genomes with paralogs
Cluster includes: ASNC LRP YBAO

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
47_K	55_A	3.582	1.00
16_A	31_Q	2.97	1.00
97_E	110_K	2.796	1.00
62_K	117_D	2.768	1.00
53_T	60_S	2.664	1.00
104_H	137_E	2.66	1.00
16_A	23_T	2.315	1.00
114_R	118_A	2.25	1.00
25_Y	43_V	2.209	1.00
75_I	135_S	2.124	1.00
13_I	28_L	2.103	1.00
45_K	49_A	2.005	1.00
53_T	58_D	1.953	1.00
118_A	121_H	1.909	1.00
44_E	48_Q	1.885	1.00
92_L	122_V	1.871	1.00
96_T	112_M	1.84	1.00
10_D	42_R	1.837	1.00
71_F	99_Y	1.832	1.00
121_H	125_N	1.83	1.00
34_V	38_T	1.812	1.00
69_G	110_K	1.788	1.00
16_A	19_G	1.709	1.00
115_S	118_A	1.661	1.00
77_K	134_Q	1.656	1.00
26_A	30_K	1.646	1.00
85_A	89_L	1.601	1.00
23_T	28_L	1.549	1.00
23_T	31_Q	1.544	1.00
32_F	39_I	1.542	1.00
27_E	30_K	1.495	1.00
94_E	126_K	1.488	1.00
81_D	84_S	1.486	1.00
17_L	43_V	1.48	1.00
72_I	111_V	1.473	1.00
25_Y	40_H	1.44	1.00
19_G	31_Q	1.438	1.00
20_N	31_Q	1.424	1.00
9_L	34_V	1.395	0.99
83_P	87_A	1.395	0.99
7_D	42_R	1.368	0.99
120_Q	143_Q	1.367	0.99
27_E	31_Q	1.35	0.99
67_D	115_S	1.341	0.99
35_S	38_T	1.341	0.99
22_R	55_A	1.337	0.99
16_A	28_L	1.328	0.99
99_Y	144_N	1.322	0.99
88_K	91_S	1.291	0.99
73_G	139_L	1.288	0.99
26_A	36_P	1.288	0.99
94_E	118_A	1.27	0.99
74_I	109_I	1.269	0.99
66_Y	114_R	1.247	0.99
98_A	109_I	1.247	0.99
144_N	147_M	1.233	0.98
92_L	126_K	1.228	0.98
86_L	90_E	1.204	0.98
68_V	116_I	1.192	0.98
34_V	39_I	1.191	0.98
12_G	15_E	1.172	0.98
44_E	47_K	1.171	0.98
71_F	108_F	1.169	0.97
9_L	32_F	1.165	0.97
25_Y	36_P	1.152	0.97
86_L	143_Q	1.143	0.97
24_A	27_E	1.127	0.97
22_R	47_K	1.126	0.97
25_Y	29_A	1.123	0.97
8_N	12_G	1.082	0.96
23_T	27_E	1.077	0.95
36_P	40_H	1.064	0.95
84_S	88_K	1.063	0.95
73_G	105_Y	1.062	0.95
54_G	58_D	1.054	0.95
28_L	43_V	1.049	0.94
88_K	130_I	1.04	0.94
9_L	12_G	1.032	0.94
113_C	118_A	1.029	0.94
21_A	57_I	1.019	0.93
12_G	16_A	1.01	0.93
116_I	140_I	1.002	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
2p5vA	8	0.9934	100	0.186	Contact Map	0.874
2e1cA	1	0.9868	100	0.191	Contact Map	0.686
2cg4A	2	1	100	0.195	Contact Map	0.6
2ia0A	2	0.9737	100	0.208	Contact Map	0.755
3i4pA	1	0.9605	100	0.226	Contact Map	0.673
2pn6A	1	0.9539	100	0.237	Contact Map	0.649
2dbbA	2	0.9737	100	0.249	Contact Map	0.78
2cyyA	1	0.9803	100	0.251	Contact Map	0.657
2gqqA	4	1	100	0.264	Contact Map	0.821
2w25A	2	0.9737	100	0.271	Contact Map	0.732

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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