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GLO2 - Hydroxyacylglutathione hydrolase
UniProt: P0AC84 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13330
Length: 251 (248)
Sequences: 2203
Seq/Len: 8.88

GLO2
Paralog alert: 0.31 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: GLO2 YCBL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
157_D 211_R 5.056 1.00
107_T 116_C 4.884 1.00
39_I 46_P 3.645 1.00
91_D 151_K 3.499 1.00
104_V 115_I 3.389 1.00
23_R 47_E 2.913 1.00
246_S 249_D 2.841 1.00
94_T 103_S 2.795 1.00
51_L 62_V 2.787 1.00
94_T 101_E 2.648 1.00
33_E 37_N 2.623 1.00
243_W 247_K 2.569 1.00
80_T 113_G 2.342 1.00
157_D 208_K 2.317 1.00
78_Q 90_K 2.282 1.00
75_Y 89_V 2.232 1.00
96_F 101_E 2.116 1.00
23_R 45_Q 2.083 1.00
188_Y 213_I 2.034 1.00
40_A 68_K 1.936 1.00
95_A 102_F 1.901 1.00
14_I 35_V 1.899 1.00
37_N 41_A 1.851 1.00
33_E 64_E 1.844 1.00
87_Q 93_E 1.841 1.00
3_L 162_C 1.82 1.00
38_A 42_N 1.802 1.00
161_V 207_L 1.794 1.00
50_F 117_Y 1.768 1.00
16_V 38_A 1.766 1.00
132_G 172_M 1.757 1.00
137_L 142_A 1.746 1.00
27_V 124_F 1.732 1.00
73_V 87_Q 1.729 1.00
36_L 69_F 1.725 1.00
109_G 148_S 1.686 1.00
116_C 123_L 1.65 1.00
147_Q 238_E 1.622 1.00
66_V 86_T 1.583 1.00
179_L 182_D 1.571 1.00
236_Q 239_E 1.564 1.00
169_L 193_K 1.553 1.00
179_L 221_D 1.548 1.00
18_N 24_C 1.535 1.00
13_Y 203_L 1.515 1.00
143_S 238_E 1.474 1.00
69_F 72_I 1.46 1.00
48_A 75_Y 1.449 0.99
176_L 189_Y 1.414 0.99
131_S 213_I 1.392 0.99
150_K 219_T 1.384 0.99
191_K 195_L 1.359 0.99
146_Y 150_K 1.357 0.99
24_C 44_W 1.348 0.99
237_P 240_R 1.343 0.99
37_N 40_A 1.34 0.99
75_Y 87_Q 1.339 0.99
123_L 161_V 1.339 0.99
225_I 237_P 1.332 0.99
139_E 145_M 1.33 0.99
246_S 250_R 1.328 0.99
8_A 14_I 1.324 0.99
73_V 86_T 1.318 0.99
149_L 217_L 1.305 0.99
102_F 119_S 1.3 0.99
238_E 242_A 1.297 0.99
90_K 93_E 1.292 0.99
109_G 137_L 1.289 0.99
222_I 226_N 1.288 0.99
66_V 74_V 1.281 0.98
168_T 180_P 1.274 0.98
208_K 212_Q 1.269 0.98
91_D 106_A 1.269 0.98
109_G 241_F 1.264 0.98
132_G 168_T 1.258 0.98
153_S 220_E 1.253 0.98
177_S 251_F 1.252 0.98
209_N 213_I 1.248 0.98
122_Y 162_C 1.247 0.98
89_V 115_I 1.233 0.98
224_L 228_I 1.229 0.98
184_S 212_Q 1.226 0.98
25_L 48_A 1.206 0.97
131_S 188_Y 1.178 0.97
183_L 187_D 1.173 0.97
176_L 186_N 1.171 0.97
156_P 159_T 1.151 0.96
188_Y 209_N 1.151 0.96
123_L 155_L 1.147 0.96
152_L 161_V 1.145 0.96
188_Y 191_K 1.136 0.96
147_Q 221_D 1.135 0.96
141_T 144_Q 1.113 0.95
64_E 68_K 1.098 0.95
176_L 185_I 1.09 0.95
3_L 122_Y 1.09 0.95
194_E 198_K 1.089 0.95
142_A 242_A 1.088 0.95
205_V 209_N 1.088 0.95
48_A 73_V 1.084 0.94
137_L 145_M 1.083 0.94
205_V 210_E 1.081 0.94
17_L 27_V 1.081 0.94
143_S 147_Q 1.079 0.94
152_L 207_L 1.075 0.94
214_N 217_L 1.072 0.94
168_T 181_H 1.072 0.94
123_L 152_L 1.067 0.94
127_D 130_F 1.065 0.94
169_L 192_V 1.061 0.94
112_L 144_Q 1.053 0.93
91_D 104_V 1.052 0.93
50_F 95_A 1.041 0.93
26_I 46_P 1.038 0.93
31_D 34_P 1.037 0.93
6_I 14_I 1.035 0.92
148_S 152_L 1.032 0.92
190_R 194_E 1.031 0.92
193_K 197_A 1.03 0.92
168_T 201_I 1.024 0.92
85_T 88_V 1.024 0.92
26_I 29_P 1.01 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1qh5A20.98011000.229Contact Map0.754
2qedA10.9961000.24Contact Map0.762
1xm8A20.9921000.251Contact Map0.808
2p18A10.96811000.288Contact Map0.699
3r2uA40.88841000.438Contact Map0.736
4efzA20.82471000.445Contact Map0.776
3tp9A20.88451000.461Contact Map0.813
2gcuA40.85661000.482Contact Map0.796
2xf4A10.72111000.532Contact Map0.784
2yheA60.97611000.554Contact Map0.562

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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