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OPENSEQ.org
WECA - Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
UniProt: P0AC78 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10840
Length: 367 (310)
Sequences: 2651
Seq/Len: 8.55
WECA
Paralog alert: 0.65 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: MRAY WECA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
263_Y 272_P 5.269 1.00
274_S 287_A 4.147 1.00
172_A 306_A 3.454 1.00
96_S 99_I 2.881 1.00
56_Y 84_V 2.876 1.00
189_C 230_I 2.854 1.00
174_G 190_F 2.852 1.00
82_V 107_V 2.743 1.00
164_G 299_T 2.643 1.00
252_A 305_L 2.564 1.00
17_T 58_G 2.455 1.00
188_W 226_T 2.234 1.00
290_T 293_Q 2.225 1.00
17_T 198_P 2.205 1.00
55_V 215_M 2.16 1.00
60_C 81_G 2.158 1.00
154_M 258_M 1.993 1.00
59_I 192_M 1.99 1.00
79_C 225_F 1.974 1.00
80_A 222_L 1.972 1.00
167_C 193_I 1.941 1.00
35_D 38_N 1.829 1.00
16_F 58_G 1.82 1.00
105_A 142_L 1.815 1.00
171_A 193_I 1.808 1.00
280_I 284_I 1.807 1.00
86_I 103_I 1.802 1.00
163_G 196_I 1.784 1.00
100_R 104_Q 1.775 1.00
76_Y 185_L 1.77 1.00
145_V 228_I 1.754 1.00
111_M 229_W 1.733 1.00
172_A 250_I 1.695 1.00
192_M 226_T 1.691 1.00
168_V 306_A 1.665 1.00
135_P 139_F 1.664 1.00
277_R 286_R 1.657 1.00
145_V 229_W 1.648 1.00
88_A 92_R 1.643 1.00
58_G 62_T 1.631 1.00
79_C 111_M 1.613 1.00
261_I 264_R 1.608 1.00
163_G 167_C 1.601 1.00
101_A 104_Q 1.595 1.00
55_V 195_A 1.578 1.00
105_A 109_I 1.57 1.00
204_L 296_V 1.56 1.00
177_L 234_T 1.54 1.00
40_R 43_H 1.537 1.00
144_A 148_A 1.536 1.00
165_L 302_A 1.531 1.00
165_L 254_P 1.519 1.00
166_S 170_F 1.513 1.00
25_R 29_K 1.508 1.00
56_Y 81_G 1.5 1.00
27_V 30_K 1.486 1.00
12_S 66_V 1.47 1.00
192_M 223_I 1.467 0.99
147_A 262_M 1.459 0.99
169_S 302_A 1.459 0.99
83_L 225_F 1.437 0.99
249_W 309_G 1.427 0.99
100_R 221_T 1.42 0.99
170_F 192_M 1.398 0.99
108_G 146_W 1.392 0.99
93_F 96_S 1.391 0.99
104_Q 149_I 1.366 0.99
293_Q 297_L 1.363 0.99
178_W 186_A 1.362 0.99
16_F 61_F 1.359 0.99
136_F 139_F 1.335 0.99
141_T 232_L 1.321 0.99
169_S 250_I 1.321 0.99
24_A 54_S 1.318 0.99
174_G 189_C 1.316 0.99
256_M 280_I 1.316 0.99
304_L 308_I 1.313 0.99
22_F 26_K 1.309 0.99
263_Y 266_L 1.309 0.99
85_F 89_L 1.309 0.99
168_V 302_A 1.3 0.99
101_A 105_A 1.294 0.98
109_I 113_V 1.294 0.98
111_M 145_V 1.293 0.98
147_A 258_M 1.291 0.98
58_G 61_F 1.291 0.98
158_I 295_F 1.29 0.98
152_F 166_S 1.288 0.98
89_L 93_F 1.285 0.98
170_F 227_V 1.284 0.98
26_K 29_K 1.282 0.98
26_K 30_K 1.279 0.98
302_A 306_A 1.272 0.98
163_G 215_M 1.271 0.98
166_S 223_I 1.268 0.98
112_M 142_L 1.264 0.98
274_S 286_R 1.247 0.98
100_R 103_I 1.242 0.98
163_G 200_I 1.238 0.98
27_V 31_V 1.231 0.98
35_D 41_K 1.219 0.97
169_S 227_V 1.216 0.97
157_G 281_H 1.212 0.97
159_D 206_I 1.21 0.97
60_C 77_L 1.208 0.97
259_V 263_Y 1.205 0.97
21_L 54_S 1.186 0.97
100_R 149_I 1.185 0.97
196_I 223_I 1.179 0.97
56_Y 80_A 1.169 0.97
155_V 165_L 1.161 0.96
170_F 189_C 1.157 0.96
162_L 223_I 1.156 0.96
153_N 217_D 1.145 0.96
284_I 298_I 1.143 0.96
79_C 229_W 1.142 0.96
170_F 193_I 1.139 0.96
55_V 196_I 1.137 0.96
80_A 226_T 1.135 0.96
38_N 41_K 1.132 0.96
282_H 285_M 1.132 0.96
62_T 191_A 1.127 0.95
100_R 154_M 1.127 0.95
257_D 281_H 1.125 0.95
206_I 211_Y 1.122 0.95
104_Q 146_W 1.111 0.95
112_M 141_T 1.11 0.95
249_W 252_A 1.11 0.95
112_M 138_Y 1.109 0.95
104_Q 150_N 1.106 0.95
18_T 201_M 1.105 0.95
63_F 73_A 1.103 0.95
43_H 214_F 1.103 0.95
258_M 262_M 1.093 0.94
191_A 194_A 1.093 0.94
152_F 162_L 1.091 0.94
21_L 213_V 1.086 0.94
255_L 258_M 1.083 0.94
47_I 214_F 1.081 0.94
188_W 230_I 1.081 0.94
205_G 292_R 1.073 0.94
177_L 186_A 1.071 0.94
201_M 297_L 1.064 0.93
80_A 188_W 1.063 0.93
16_F 62_T 1.058 0.93
56_Y 222_L 1.056 0.93
167_C 197_L 1.055 0.93
169_S 254_P 1.053 0.93
140_L 144_A 1.043 0.92
14_F 201_M 1.04 0.92
168_V 299_T 1.034 0.92
222_L 226_T 1.027 0.92
174_G 178_W 1.019 0.91
149_I 225_F 1.016 0.91
78_A 82_V 1.012 0.91
152_F 169_S 1.011 0.91
301_A 305_L 1.004 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4j72A20.82291000.311Contact Map0.733
2ls4A10.06545.70.974Contact Map0.728
2lzrA10.13940.976Contact Map0.389
2jlnA10.16623.50.977Contact Map0.29
2i68A20.324330.978Contact Map0.056
3j01B10.20712.30.979Contact Map0.043
2b2hA10.163520.98Contact Map0.27
1ifkA10.08721.50.981Contact Map0.354
3ne5A10.23711.50.981Contact Map0.363
3j3bn10.06811.40.981Contact Map
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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