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OPENSEQ.org
KDTA - 3-deoxy-D-manno-octulosonic acid transferase
UniProt: P0AC75 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10520
Length: 425 (420)
Sequences: 1076
Seq/Len: 2.56
KDTA
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
72_R 100_D 3.499 1.00
323_F 328_L 3.492 1.00
324_V 339_A 3.191 1.00
119_N 144_R 3.049 1.00
147_P 178_T 2.778 1.00
150_I 177_I 2.701 1.00
348_M 368_L 2.673 1.00
184_N 187_D 2.649 1.00
291_R 311_E 2.588 1.00
70_A 410_Q 2.579 1.00
384_L 394_Y 2.568 1.00
256_L 302_Q 2.516 1.00
373_D 376_T 2.381 1.00
235_W 252_H 2.372 1.00
252_H 264_L 2.289 1.00
210_D 407_G 2.244 1.00
322_A 344_I 2.219 1.00
281_V 288_Y 2.167 1.00
275_P 290_T 2.143 1.00
308_T 311_E 2.128 1.00
281_V 305_V 2.094 1.00
267_V 306_G 2.094 1.00
336_P 359_C 2.066 1.00
158_R 162_G 2.041 1.00
64_A 129_M 2.016 0.99
249_I 281_V 2.016 0.99
67_L 151_A 1.937 0.99
372_T 376_T 1.937 0.99
81_T 121_V 1.887 0.99
306_G 315_L 1.883 0.99
90_S 103_H 1.841 0.99
290_T 305_V 1.835 0.99
118_L 144_R 1.831 0.99
232_R 263_L 1.815 0.99
115_N 140_A 1.794 0.99
138_I 176_R 1.785 0.98
237_A 264_L 1.767 0.98
138_I 148_L 1.767 0.98
22_W 25_G 1.766 0.98
179_L 202_T 1.735 0.98
348_M 359_C 1.733 0.98
127_L 151_A 1.714 0.98
388_A 391_R 1.709 0.98
125_L 149_V 1.678 0.97
391_R 395_G 1.678 0.97
185_E 189_A 1.666 0.97
126_V 141_L 1.648 0.97
250_A 284_A 1.635 0.97
241_H 334_H 1.621 0.97
129_M 151_A 1.605 0.96
363_E 368_L 1.603 0.96
51_I 80_I 1.589 0.96
153_A 182_A 1.588 0.96
255_L 262_L 1.579 0.96
56_V 85_M 1.575 0.96
245_E 273_R 1.552 0.95
142_H 176_R 1.548 0.95
106_L 137_L 1.544 0.95
188_G 201_V 1.533 0.95
83_T 117_F 1.532 0.95
237_A 240_T 1.527 0.95
274_F 277_A 1.52 0.95
87_P 105_Y 1.515 0.95
366_S 397_H 1.512 0.94
277_A 280_L 1.502 0.94
68_V 82_V 1.501 0.94
114_L 118_L 1.476 0.94
142_H 178_T 1.475 0.93
352_T 370_T 1.472 0.93
348_M 363_E 1.461 0.93
267_V 309_M 1.457 0.93
133_L 173_L 1.45 0.93
84_T 103_H 1.438 0.92
61_T 93_V 1.435 0.92
181_A 415_L 1.431 0.92
317_G 342_H 1.43 0.92
177_I 180_I 1.429 0.92
15_P 19_I 1.41 0.91
83_T 104_V 1.404 0.91
153_A 180_I 1.398 0.91
237_A 252_H 1.397 0.91
70_A 74_R 1.392 0.91
210_D 408_A 1.389 0.90
236_I 319_A 1.387 0.90
148_L 177_I 1.381 0.90
343_A 399_V 1.378 0.90
362_L 401_V 1.37 0.90
118_L 141_L 1.362 0.89
81_T 104_V 1.36 0.89
92_R 95_S 1.359 0.89
182_A 187_D 1.352 0.89
331_R 334_H 1.349 0.89
291_R 308_T 1.346 0.89
278_I 288_Y 1.342 0.88
394_Y 397_H 1.34 0.88
146_I 178_T 1.335 0.88
126_V 148_L 1.324 0.87
340_A 346_V 1.313 0.87
240_T 245_E 1.311 0.87
262_L 385_L 1.308 0.87
52_M 81_T 1.307 0.87
340_A 395_G 1.307 0.87
149_V 416_L 1.305 0.86
371_V 377_L 1.304 0.86
50_G 81_T 1.299 0.86
115_N 144_R 1.293 0.86
312_L 316_Y 1.291 0.86
347_L 380_E 1.289 0.86
392_S 396_R 1.279 0.85
278_I 282_R 1.278 0.85
138_I 177_I 1.277 0.85
278_I 305_V 1.276 0.85
240_T 273_R 1.271 0.84
31_Y 87_P 1.268 0.84
383_S 390_Y 1.263 0.84
160_A 164_A 1.259 0.84
84_T 93_V 1.258 0.84
25_G 32_R 1.257 0.84
278_I 290_T 1.252 0.83
352_T 359_C 1.252 0.83
149_V 419_Y 1.251 0.83
151_A 412_L 1.251 0.83
188_G 203_V 1.232 0.82
34_R 90_S 1.23 0.82
343_A 395_G 1.226 0.81
71_L 80_I 1.226 0.81
252_H 256_L 1.223 0.81
383_S 387_D 1.221 0.81
141_L 148_L 1.22 0.81
155_L 191_F 1.217 0.81
196_A 201_V 1.213 0.80
363_E 370_T 1.212 0.80
51_I 125_L 1.212 0.80
347_L 394_Y 1.208 0.80
253_Q 286_L 1.207 0.80
336_P 352_T 1.205 0.80
340_A 362_L 1.199 0.79
111_P 136_N 1.199 0.79
365_A 404_Q 1.196 0.79
390_Y 394_Y 1.195 0.79
208_K 269_R 1.193 0.79
65_I 96_A 1.191 0.79
91_E 95_S 1.189 0.79
347_L 384_L 1.188 0.78
20_R 25_G 1.173 0.77
93_V 103_H 1.168 0.77
88_T 271_P 1.163 0.76
393_F 397_H 1.159 0.76
367_G 398_A 1.157 0.76
246_S 280_L 1.157 0.76
387_D 391_R 1.152 0.75
312_L 315_L 1.14 0.74
188_G 192_V 1.138 0.74
253_Q 284_A 1.137 0.74
98_G 101_V 1.131 0.74
387_D 390_Y 1.122 0.73
182_A 191_F 1.121 0.73
34_R 103_H 1.119 0.72
316_Y 324_V 1.117 0.72
326_G 334_H 1.114 0.72
184_N 315_L 1.114 0.72
131_T 163_Y 1.113 0.72
55_S 61_T 1.112 0.72
234_V 265_I 1.111 0.72
130_E 208_K 1.111 0.72
154_R 208_K 1.107 0.71
238_T 316_Y 1.103 0.71
237_A 248_V 1.098 0.70
288_Y 305_V 1.097 0.70
336_P 362_L 1.09 0.70
106_L 316_Y 1.089 0.69
323_F 371_V 1.085 0.69
93_V 101_V 1.085 0.69
275_P 305_V 1.084 0.69
254_A 375_T 1.074 0.68
130_E 269_R 1.057 0.66
65_I 97_F 1.057 0.66
141_L 146_I 1.056 0.66
84_T 90_S 1.05 0.65
396_R 400_E 1.05 0.65
20_R 28_A 1.048 0.65
170_V 174_L 1.044 0.65
255_L 382_S 1.044 0.65
334_H 355_F 1.043 0.65
390_Y 393_F 1.034 0.64
208_K 333_G 1.027 0.63
241_H 331_R 1.027 0.63
118_L 146_I 1.017 0.62
82_V 93_V 1.017 0.62
6_Y 10_L 1.015 0.61
348_M 352_T 1.013 0.61
119_N 146_I 1.01 0.61
254_A 257_Q 1.006 0.60
140_A 143_K 1.003 0.60
185_E 203_V 1.002 0.60
72_R 101_V 1.001 0.60
132_E 154_R 1.001 0.60
348_M 370_T 1.001 0.60
160_A 193_A 1 0.60
245_E 276_D 1 0.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2xciA40.87531000.55Contact Map0.639
4hwgA10.82351000.74Contact Map0.55
1v4vA20.81181000.757Contact Map0.56
1vgvA40.81181000.759Contact Map0.669
3dzcA20.84941000.769Contact Map0.672
4fkzA20.81181000.787Contact Map0.67
3ot5A40.858899.90.808Contact Map0.696
2vsyA20.915399.90.832Contact Map0.451
3okpA10.849499.80.843Contact Map0.583
2iw1A10.811899.80.848Contact Map0.462
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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