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NRDH - Glutaredoxin-like protein NrdH
UniProt: P0AC65 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13286
Length: 81 (76)
Sequences: 2123
Seq/Len: 27.93

NRDH
Paralog alert: 0.47 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: GLRX1 GLRX3 NRDH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
22_E 28_F 3.947 1.00
24_R 70_N 2.552 1.00
3_I 26_F 2.467 1.00
9_N 32_N 2.235 1.00
7_T 30_M 2.132 1.00
18_K 30_M 2.066 1.00
68_M 71_R 1.958 1.00
17_T 54_V 1.796 1.00
9_N 34_D 1.78 1.00
8_R 51_L 1.742 1.00
39_A 42_A 1.721 1.00
7_T 18_K 1.71 1.00
36_V 39_A 1.689 1.00
4_T 31_I 1.659 1.00
16_A 64_F 1.543 1.00
5_I 21_M 1.519 1.00
48_F 60_S 1.494 1.00
40_A 44_R 1.475 1.00
19_R 23_N 1.47 1.00
59_L 72_L 1.42 1.00
20_A 69_I 1.385 0.99
53_V 60_S 1.338 0.99
44_R 49_R 1.297 0.99
32_N 35_R 1.295 0.99
48_F 53_V 1.291 0.99
20_A 24_R 1.284 0.99
42_A 45_A 1.25 0.99
33_V 51_L 1.165 0.97
16_A 19_R 1.132 0.97
56_A 61_W 1.114 0.96
10_D 34_D 1.109 0.96
12_V 15_H 1.091 0.96
46_Q 53_V 1.082 0.96
59_L 68_M 1.08 0.95
9_N 35_R 1.058 0.95
19_R 22_E 1.054 0.95
61_W 72_L 1.05 0.94
13_Q 50_Q 1.029 0.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1u6tA10.987799.80.222Contact Map0.759
2jadA1199.80.225Contact Map0.549
2ct6A1199.70.254Contact Map0.642
2wciA2199.70.266Contact Map0.708
1t1vA20.938399.60.301Contact Map0.809
2wemA4199.60.308Contact Map0.728
3gx8A1199.60.316Contact Map0.611
1wikA1199.60.322Contact Map0.702
2ltkA1199.60.324Contact Map0.788
4hs1A1199.60.328Contact Map0.789

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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