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OPENSEQ.org
G6PD - Glucose-6-phosphate 1-dehydrogenase
UniProt: P0AC53 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11221
Length: 491 (481)
Sequences: 1424
Seq/Len: 2.96
G6PD
Paralog alert: 0.12 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
272_R 324_D 4.423 1.00
263_E 266_K 4.073 1.00
54_D 57_A 3.774 1.00
225_Y 229_A 3.187 1.00
119_M 127_I 3.038 1.00
464_K 475_A 2.99 1.00
63_R 67_E 2.973 1.00
285_R 456_W 2.859 1.00
271_L 448_W 2.846 1.00
262_D 438_R 2.793 1.00
207_D 485_R 2.72 1.00
79_W 83_S 2.629 1.00
248_A 333_F 2.55 1.00
209_V 333_F 2.52 1.00
144_V 428_T 2.482 1.00
152_S 155_T 2.37 1.00
163_V 172_V 2.365 1.00
226_F 231_Q 2.29 1.00
145_M 163_V 2.262 1.00
151_T 155_T 2.255 1.00
444_E 447_K 2.253 1.00
95_D 98_A 2.238 1.00
17_A 58_Y 2.21 1.00
55_K 59_T 2.205 1.00
231_Q 337_T 2.166 1.00
342_P 471_W 2.138 1.00
347_E 375_R 2.108 1.00
143_V 167_F 2.044 1.00
262_D 440_D 2.039 1.00
149_L 159_I 2.021 1.00
76_E 80_D 1.948 0.99
27_L 62_V 1.93 0.99
96_T 133_E 1.919 0.99
128_C 163_V 1.89 0.99
286_G 465_P 1.887 0.99
120_P 123_T 1.861 0.99
129_K 165_E 1.861 0.99
349_V 371_K 1.814 0.99
320_R 483_D 1.813 0.99
291_G 298_V 1.807 0.99
60_K 64_E 1.802 0.99
272_R 322_D 1.789 0.99
55_K 87_D 1.789 0.99
300_G 303_E 1.784 0.99
227_D 313_T 1.78 0.99
289_T 465_P 1.758 0.99
52_D 90_N 1.744 0.99
190_L 382_V 1.742 0.99
450_D 454_E 1.741 0.99
114_I 428_T 1.74 0.99
189_A 399_L 1.734 0.99
157_Q 443_E 1.722 0.98
261_R 438_R 1.709 0.98
129_K 133_E 1.7 0.98
243_I 348_V 1.685 0.98
100_S 133_E 1.673 0.98
241_L 268_L 1.658 0.98
168_E 171_Q 1.655 0.98
372_L 384_I 1.655 0.98
137_N 167_F 1.608 0.97
52_D 57_A 1.588 0.97
256_S 259_S 1.585 0.97
34_E 85_R 1.558 0.97
101_R 104_A 1.554 0.97
208_H 485_R 1.548 0.96
20_D 24_R 1.548 0.96
283_T 452_I 1.545 0.96
160_N 443_E 1.543 0.96
271_L 321_V 1.536 0.96
93_V 123_T 1.531 0.96
81_T 84_A 1.53 0.96
340_R 468_A 1.527 0.96
210_E 351_Y 1.523 0.96
22_A 27_L 1.522 0.96
87_D 105_M 1.517 0.96
209_V 248_A 1.504 0.96
334_Y 483_D 1.498 0.96
231_Q 314_E 1.492 0.95
201_W 206_I 1.492 0.95
478_A 481_T 1.48 0.95
301_Y 307_A 1.476 0.95
264_K 441_E 1.476 0.95
349_V 488_N 1.475 0.95
103_G 107_D 1.464 0.95
132_G 166_Y 1.443 0.94
262_D 269_K 1.441 0.94
236_I 317_V 1.433 0.94
251_P 326_W 1.431 0.94
213_V 346_S 1.429 0.94
200_N 352_F 1.428 0.94
298_V 340_R 1.424 0.94
14_I 22_A 1.415 0.93
96_T 130_G 1.415 0.93
235_M 337_T 1.414 0.93
290_A 297_K 1.405 0.93
17_A 47_G 1.394 0.93
240_L 335_L 1.388 0.92
265_V 438_R 1.367 0.92
386_V 404_L 1.367 0.92
467_Q 470_T 1.356 0.91
250_S 327_R 1.33 0.90
24_R 235_M 1.33 0.90
197_F 384_I 1.321 0.90
195_S 205_T 1.321 0.90
450_D 453_T 1.32 0.90
57_A 60_K 1.313 0.89
371_K 488_N 1.311 0.89
290_A 303_E 1.306 0.89
292_F 295_G 1.302 0.89
352_F 372_L 1.3 0.89
18_K 51_A 1.295 0.89
321_V 448_W 1.293 0.88
112_I 140_P 1.291 0.88
25_K 419_D 1.288 0.88
182_E 389_K 1.286 0.88
96_T 134_A 1.284 0.88
34_E 82_L 1.274 0.87
48_V 91_L 1.274 0.87
241_L 449_V 1.272 0.87
449_V 452_I 1.271 0.87
153_L 443_E 1.262 0.87
153_L 157_Q 1.26 0.87
236_I 337_T 1.259 0.87
316_F 477_V 1.257 0.87
236_I 319_I 1.257 0.87
203_N 353_K 1.248 0.86
296_K 299_P 1.244 0.86
125_G 162_Q 1.237 0.85
53_W 57_A 1.234 0.85
212_T 336_R 1.234 0.85
33_L 43_T 1.232 0.85
91_L 98_A 1.231 0.85
218_G 340_R 1.23 0.85
213_V 235_M 1.227 0.85
290_A 468_A 1.227 0.85
207_D 353_K 1.224 0.85
347_E 373_T 1.218 0.84
128_C 143_V 1.217 0.84
96_T 100_S 1.212 0.84
46_I 87_D 1.211 0.84
46_I 105_M 1.211 0.84
286_G 463_P 1.21 0.84
382_V 386_V 1.206 0.83
221_G 305_E 1.197 0.83
34_E 81_T 1.195 0.83
481_T 486_S 1.193 0.82
55_K 105_M 1.189 0.82
336_R 487_W 1.185 0.82
62_V 86_L 1.182 0.82
89_C 105_M 1.177 0.81
474_V 478_A 1.175 0.81
247_I 348_V 1.171 0.81
33_L 426_L 1.171 0.81
59_T 87_D 1.169 0.81
16_G 19_G 1.166 0.80
389_K 392_G 1.155 0.79
14_I 26_L 1.152 0.79
78_L 81_T 1.151 0.79
244_L 271_L 1.148 0.79
302_L 310_S 1.141 0.78
326_W 356_E 1.131 0.77
269_K 444_E 1.13 0.77
407_S 410_E 1.129 0.77
154_A 454_E 1.124 0.77
227_D 302_L 1.122 0.77
428_T 437_V 1.121 0.77
314_E 457_A 1.121 0.77
66_L 79_W 1.118 0.76
210_E 487_W 1.117 0.76
11_D 44_R 1.117 0.76
178_Y 377_Q 1.116 0.76
444_E 451_S 1.115 0.76
293_A 298_V 1.115 0.76
218_G 304_E 1.115 0.76
203_N 331_V 1.114 0.76
261_R 440_D 1.108 0.75
210_E 318_A 1.107 0.75
351_Y 371_K 1.105 0.75
197_F 352_F 1.104 0.75
302_L 465_P 1.104 0.75
284_V 475_A 1.104 0.75
232_M 456_W 1.103 0.75
302_L 308_N 1.097 0.74
154_A 157_Q 1.097 0.74
129_K 162_Q 1.095 0.74
418_A 422_E 1.09 0.74
258_D 269_K 1.09 0.74
63_R 76_E 1.088 0.74
48_V 124_F 1.087 0.73
478_A 482_R 1.086 0.73
15_F 127_I 1.083 0.73
62_V 66_L 1.083 0.73
158_E 162_Q 1.081 0.73
80_D 84_A 1.081 0.73
122_S 228_K 1.08 0.73
247_I 350_V 1.079 0.73
30_L 45_I 1.078 0.73
197_F 386_V 1.075 0.72
154_A 158_E 1.075 0.72
399_L 435_L 1.073 0.72
64_E 68_T 1.071 0.72
474_V 477_V 1.071 0.72
226_F 337_T 1.07 0.72
59_T 83_S 1.064 0.71
283_T 319_I 1.064 0.71
274_I 282_K 1.062 0.71
227_D 308_N 1.057 0.70
16_G 21_L 1.056 0.70
275_D 278_N 1.056 0.70
10_C 33_L 1.055 0.70
49_G 88_F 1.048 0.69
185_L 427_E 1.046 0.69
377_Q 380_E 1.046 0.69
10_C 429_M 1.045 0.69
25_K 178_Y 1.043 0.69
125_G 158_E 1.042 0.69
203_N 356_E 1.041 0.69
349_V 373_T 1.038 0.68
208_H 351_Y 1.036 0.68
69_F 217_V 1.033 0.68
223_W 307_A 1.033 0.68
278_N 281_E 1.032 0.68
56_A 59_T 1.031 0.68
12_L 26_L 1.029 0.67
283_T 317_V 1.024 0.67
338_G 341_L 1.023 0.67
24_R 217_V 1.023 0.67
89_C 101_R 1.02 0.66
202_D 205_T 1.015 0.66
53_W 61_V 1.014 0.66
346_S 376_L 1.014 0.66
299_P 303_E 1.012 0.66
284_V 476_S 1.01 0.65
169_E 440_D 1.007 0.65
258_D 261_R 1.003 0.65
265_V 440_D 1.001 0.64
13_V 211_I 1.001 0.64
77_G 80_D 1.001 0.64
274_I 278_N 1 0.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1dpgA20.97151000.004Contact Map0.699
2bh9A10.96741000.014Contact Map0.666
4e9iA40.96741000.018Contact Map0.722
4lgvA40.93691000.048Contact Map0.681
3f4lA60.6741960.965Contact Map0.55
3u3xA50.66695.70.966Contact Map0.438
3i23A20.670195.40.967Contact Map0.537
2glxA60.645695.30.967Contact Map0.524
3rc1A10.639594.90.968Contact Map0.554
4koaA10.643694.60.968Contact Map0.49
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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