| UniProt: | P0AC38 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10095 | ||
| Length: | 478 (461) | ||
| Sequences: | 4772 | ||
| Seq/Len: | 10.35 |
| ASPA
Paralog alert: 0.83 [within 20: 0.04] - ratio of genomes with paralogs Cluster includes: ARLY ASPA FUMC PUR8 |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 63_K | 73_A | 3.562 | 1.00 | |
| 346_N | 375_S | 3.426 | 1.00 | |
| 72_V | 137_H | 3.354 | 1.00 | |
| 430_I | 434_T | 3.309 | 1.00 | |
| 400_V | 403_G | 3.298 | 1.00 | |
| 161_I | 222_A | 3.259 | 1.00 | |
| 56_K | 81_D | 3.151 | 1.00 | |
| 60_M | 77_I | 3.004 | 1.00 | |
| 288_A | 343_V | 2.976 | 1.00 | |
| 449_T | 452_E | 2.934 | 1.00 | |
| 200_L | 396_A | 2.805 | 1.00 | |
| 402_E | 406_Y | 2.737 | 1.00 | |
| 183_D | 398_K | 2.73 | 1.00 | |
| 171_R | 212_K | 2.725 | 1.00 | |
| 164_V | 215_V | 2.721 | 1.00 | |
| 224_L | 279_M | 2.663 | 1.00 | |
| 173_G | 392_N | 2.508 | 1.00 | |
| 339_V | 382_A | 2.476 | 1.00 | |
| 160_L | 280_V | 2.449 | 1.00 | |
| 252_K | 255_E | 2.441 | 1.00 | |
| 313_N | 395_T | 2.436 | 1.00 | |
| 168_N | 219_Q | 2.42 | 1.00 | |
| 285_K | 347_D | 2.412 | 1.00 | |
| 177_K | 180_E | 2.38 | 1.00 | |
| 313_N | 397_N | 2.353 | 1.00 | |
| 64_E | 252_K | 2.317 | 1.00 | |
| 176_R | 180_E | 2.29 | 1.00 | |
| 176_R | 392_N | 2.274 | 1.00 | |
| 164_V | 219_Q | 2.263 | 1.00 | |
| 168_N | 215_V | 2.233 | 1.00 | |
| 289_V | 344_I | 2.206 | 1.00 | |
| 22_Y | 120_E | 2.195 | 1.00 | |
| 117_I | 121_L | 2.18 | 1.00 | |
| 157_Y | 226_L | 2.172 | 1.00 | |
| 173_G | 387_L | 2.113 | 1.00 | |
| 63_K | 70_K | 2.112 | 1.00 | |
| 226_L | 260_P | 2.087 | 1.00 | |
| 436_K | 444_E | 2.07 | 1.00 | |
| 60_M | 256_V | 2.062 | 1.00 | |
| 430_I | 445_R | 2.012 | 1.00 | |
| 439_R | 454_D | 2.01 | 1.00 | |
| 169_Q | 388_E | 2.01 | 1.00 | |
| 220_R | 223_E | 2.003 | 1.00 | |
| 315_P | 393_G | 1.992 | 1.00 | |
| 400_V | 404_Y | 1.973 | 1.00 | |
| 69_P | 72_V | 1.955 | 1.00 | |
| 70_K | 74_N | 1.949 | 1.00 | |
| 291_M | 336_V | 1.948 | 1.00 | |
| 215_V | 219_Q | 1.942 | 1.00 | |
| 7_I | 16_E | 1.925 | 1.00 | |
| 220_R | 224_L | 1.923 | 1.00 | |
| 74_N | 78_A | 1.921 | 1.00 | |
| 342_K | 371_A | 1.886 | 1.00 | |
| 173_G | 391_I | 1.881 | 1.00 | |
| 171_R | 215_V | 1.869 | 1.00 | |
| 264_A | 270_A | 1.85 | 1.00 | |
| 418_F | 452_E | 1.825 | 1.00 | |
| 349_T | 367_V | 1.822 | 1.00 | |
| 232_A | 270_A | 1.799 | 1.00 | |
| 387_L | 392_N | 1.783 | 1.00 | |
| 166_A | 384_Y | 1.777 | 1.00 | |
| 169_Q | 387_L | 1.766 | 1.00 | |
| 398_K | 402_E | 1.765 | 1.00 | |
| 452_E | 455_D | 1.739 | 1.00 | |
| 403_G | 407_N | 1.725 | 1.00 | |
| 402_E | 460_Q | 1.699 | 1.00 | |
| 223_E | 260_P | 1.694 | 1.00 | |
| 181_F | 184_I | 1.69 | 1.00 | |
| 450_E | 454_D | 1.69 | 1.00 | |
| 72_V | 131_Y | 1.678 | 1.00 | |
| 60_M | 252_K | 1.669 | 1.00 | |
| 73_A | 77_I | 1.654 | 1.00 | |
| 214_E | 290_K | 1.65 | 1.00 | |
| 333_P | 390_C | 1.631 | 1.00 | |
| 350_V | 372_M | 1.609 | 1.00 | |
| 423_N | 426_I | 1.602 | 1.00 | |
| 248_L | 251_K | 1.594 | 1.00 | |
| 213_E | 275_G | 1.594 | 1.00 | |
| 213_E | 269_E | 1.568 | 1.00 | |
| 230_L | 249_A | 1.542 | 1.00 | |
| 175_E | 212_K | 1.539 | 1.00 | |
| 177_K | 391_I | 1.517 | 1.00 | |
| 166_A | 380_T | 1.514 | 1.00 | |
| 171_R | 211_L | 1.512 | 1.00 | |
| 59_A | 68_I | 1.505 | 1.00 | |
| 458_S | 461_N | 1.497 | 1.00 | |
| 216_K | 223_E | 1.495 | 1.00 | |
| 423_N | 447_L | 1.487 | 1.00 | |
| 159_S | 380_T | 1.487 | 1.00 | |
| 430_I | 441_V | 1.483 | 1.00 | |
| 436_K | 441_V | 1.483 | 1.00 | |
| 228_V | 254_A | 1.481 | 1.00 | |
| 397_N | 400_V | 1.478 | 1.00 | |
| 285_K | 351_T | 1.475 | 1.00 | |
| 175_E | 179_V | 1.469 | 1.00 | |
| 46_E | 158_S | 1.456 | 1.00 | |
| 282_G | 286_R | 1.453 | 1.00 | |
| 254_A | 260_P | 1.448 | 1.00 | |
| 217_N | 279_M | 1.436 | 1.00 | |
| 200_L | 204_F | 1.428 | 1.00 | |
| 23_Y | 28_L | 1.418 | 1.00 | |
| 419_I | 424_G | 1.416 | 1.00 | |
| 64_E | 248_L | 1.407 | 0.99 | |
| 81_D | 85_N | 1.402 | 0.99 | |
| 300_L | 358_Q | 1.401 | 0.99 | |
| 5_I | 16_E | 1.4 | 0.99 | |
| 278_V | 286_R | 1.389 | 0.99 | |
| 82_E | 121_L | 1.385 | 0.99 | |
| 28_L | 31_I | 1.379 | 0.99 | |
| 342_K | 374_E | 1.379 | 0.99 | |
| 7_I | 14_T | 1.375 | 0.99 | |
| 167_I | 211_L | 1.372 | 0.99 | |
| 177_K | 181_F | 1.366 | 0.99 | |
| 429_K | 433_E | 1.365 | 0.99 | |
| 443_L | 450_E | 1.365 | 0.99 | |
| 56_K | 77_I | 1.358 | 0.99 | |
| 312_I | 394_I | 1.357 | 0.99 | |
| 336_V | 382_A | 1.357 | 0.99 | |
| 388_E | 392_N | 1.357 | 0.99 | |
| 204_F | 207_F | 1.353 | 0.99 | |
| 168_N | 172_E | 1.346 | 0.99 | |
| 110_T | 114_L | 1.335 | 0.99 | |
| 61_A | 252_K | 1.332 | 0.99 | |
| 81_D | 84_L | 1.331 | 0.99 | |
| 164_V | 222_A | 1.33 | 0.99 | |
| 295_C | 336_V | 1.33 | 0.99 | |
| 119_L | 127_G | 1.32 | 0.99 | |
| 274_C | 365_E | 1.317 | 0.99 | |
| 179_V | 182_Q | 1.316 | 0.99 | |
| 434_T | 441_V | 1.313 | 0.99 | |
| 75_A | 122_M | 1.313 | 0.99 | |
| 167_I | 287_L | 1.312 | 0.99 | |
| 251_K | 255_E | 1.306 | 0.99 | |
| 52_V | 110_T | 1.302 | 0.99 | |
| 218_I | 287_L | 1.301 | 0.99 | |
| 171_R | 208_S | 1.3 | 0.99 | |
| 399_E | 403_G | 1.283 | 0.99 | |
| 280_V | 376_V | 1.275 | 0.99 | |
| 170_L | 391_I | 1.275 | 0.99 | |
| 280_V | 372_M | 1.274 | 0.99 | |
| 207_F | 294_I | 1.274 | 0.99 | |
| 56_K | 60_M | 1.271 | 0.99 | |
| 9_E | 14_T | 1.27 | 0.99 | |
| 78_A | 121_L | 1.27 | 0.99 | |
| 180_E | 395_T | 1.267 | 0.99 | |
| 178_A | 208_S | 1.262 | 0.99 | |
| 295_C | 386_L | 1.26 | 0.99 | |
| 67_T | 140_K | 1.25 | 0.99 | |
| 207_F | 360_Q | 1.249 | 0.99 | |
| 64_E | 245_Y | 1.247 | 0.99 | |
| 221_T | 283_A | 1.243 | 0.98 | |
| 167_I | 215_V | 1.243 | 0.98 | |
| 63_K | 74_N | 1.237 | 0.98 | |
| 51_M | 54_V | 1.235 | 0.98 | |
| 183_D | 201_G | 1.227 | 0.98 | |
| 53_M | 158_S | 1.225 | 0.98 | |
| 245_Y | 256_V | 1.224 | 0.98 | |
| 283_A | 287_L | 1.218 | 0.98 | |
| 15_R | 32_E | 1.215 | 0.98 | |
| 216_K | 224_L | 1.213 | 0.98 | |
| 51_M | 147_A | 1.206 | 0.98 | |
| 42_S | 377_H | 1.2 | 0.98 | |
| 50_G | 158_S | 1.196 | 0.98 | |
| 53_M | 253_L | 1.192 | 0.98 | |
| 49_R | 53_M | 1.192 | 0.98 | |
| 169_Q | 392_N | 1.186 | 0.98 | |
| 75_A | 78_A | 1.18 | 0.98 | |
| 298_L | 333_P | 1.178 | 0.98 | |
| 451_A | 455_D | 1.176 | 0.98 | |
| 437_S | 440_E | 1.174 | 0.98 | |
| 117_I | 120_E | 1.166 | 0.97 | |
| 227_E | 262_V | 1.165 | 0.97 | |
| 184_I | 401_C | 1.161 | 0.97 | |
| 166_A | 387_L | 1.16 | 0.97 | |
| 57_A | 256_V | 1.159 | 0.97 | |
| 205_R | 266_D | 1.156 | 0.97 | |
| 310_N | 400_V | 1.154 | 0.97 | |
| 156_V | 280_V | 1.143 | 0.97 | |
| 11_L | 425_D | 1.138 | 0.97 | |
| 244_E | 248_L | 1.133 | 0.97 | |
| 64_E | 70_K | 1.132 | 0.97 | |
| 46_E | 377_H | 1.126 | 0.97 | |
| 189_R | 194_D | 1.126 | 0.97 | |
| 63_K | 68_I | 1.122 | 0.97 | |
| 45_P | 49_R | 1.121 | 0.97 | |
| 9_E | 422_H | 1.118 | 0.96 | |
| 56_K | 84_L | 1.115 | 0.96 | |
| 216_K | 220_R | 1.111 | 0.96 | |
| 74_N | 77_I | 1.109 | 0.96 | |
| 277_Y | 372_M | 1.108 | 0.96 | |
| 453_L | 457_F | 1.101 | 0.96 | |
| 119_L | 124_H | 1.099 | 0.96 | |
| 166_A | 169_Q | 1.097 | 0.96 | |
| 248_L | 252_K | 1.097 | 0.96 | |
| 292_S | 337_N | 1.096 | 0.96 | |
| 163_L | 379_L | 1.088 | 0.96 | |
| 46_E | 159_S | 1.087 | 0.96 | |
| 175_E | 208_S | 1.084 | 0.96 | |
| 185_L | 463_M | 1.076 | 0.95 | |
| 344_I | 348_T | 1.072 | 0.95 | |
| 440_E | 444_E | 1.072 | 0.95 | |
| 141_C | 242_P | 1.068 | 0.95 | |
| 191_Q | 334_E | 1.068 | 0.95 | |
| 278_V | 354_A | 1.066 | 0.95 | |
| 65_L | 242_P | 1.066 | 0.95 | |
| 277_Y | 350_V | 1.062 | 0.95 | |
| 208_S | 212_K | 1.062 | 0.95 | |
| 209_I | 213_E | 1.061 | 0.95 | |
| 181_F | 396_A | 1.061 | 0.95 | |
| 160_L | 222_A | 1.06 | 0.95 | |
| 340_C | 344_I | 1.055 | 0.95 | |
| 200_L | 401_C | 1.055 | 0.95 | |
| 52_V | 83_V | 1.053 | 0.95 | |
| 291_M | 383_C | 1.052 | 0.95 | |
| 22_Y | 89_C | 1.051 | 0.94 | |
| 442_V | 445_R | 1.051 | 0.94 | |
| 436_K | 440_E | 1.045 | 0.94 | |
| 173_G | 176_R | 1.045 | 0.94 | |
| 182_Q | 201_G | 1.043 | 0.94 | |
| 164_V | 168_N | 1.04 | 0.94 | |
| 345_G | 349_T | 1.039 | 0.94 | |
| 5_I | 19_A | 1.035 | 0.94 | |
| 175_E | 178_A | 1.033 | 0.94 | |
| 26_H | 319_A | 1.03 | 0.94 | |
| 421_H | 425_D | 1.027 | 0.94 | |
| 287_L | 383_C | 1.026 | 0.94 | |
| 53_M | 256_V | 1.022 | 0.93 | |
| 82_E | 117_I | 1.02 | 0.93 | |
| 174_F | 294_I | 1.018 | 0.93 | |
| 28_L | 32_E | 1.018 | 0.93 | |
| 71_S | 75_A | 1.012 | 0.93 | |
| 52_V | 84_L | 1.012 | 0.93 | |
| 157_Y | 259_F | 1.009 | 0.93 | |
| 169_Q | 384_Y | 1.007 | 0.93 | |
| 430_I | 436_K | 1.003 | 0.93 | |
| 198_M | 235_I | 1.001 | 0.92 | |
| 181_F | 398_K | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1jswA | 4 | 1 | 100 | 0.078 | Contact Map | 0.816 |
| 1yfmA | 1 | 0.9707 | 100 | 0.082 | Contact Map | 0.648 |
| 1furA | 2 | 0.9749 | 100 | 0.087 | Contact Map | 0.712 |
| 3r6qA | 8 | 0.9791 | 100 | 0.087 | Contact Map | 0.819 |
| 1vdkA | 2 | 0.9707 | 100 | 0.091 | Contact Map | 0.719 |
| 4hgvA | 4 | 0.9686 | 100 | 0.093 | Contact Map | 0.749 |
| 3e04A | 4 | 0.9707 | 100 | 0.101 | Contact Map | 0.787 |
| 3ocfA | 4 | 0.9623 | 100 | 0.102 | Contact Map | 0.748 |
| 3gtdA | 2 | 0.9623 | 100 | 0.106 | Contact Map | 0.681 |
| 4admA | 4 | 0.9665 | 100 | 0.108 | Contact Map | 0.734 |
Sequence Conservation (Image Generated using WebLogo v3)