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OPENSEQ.org

YGFA - Uncharacterized protein YgfA
UniProt: P0AC28 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11158
Length: 182 (182)
Sequences: 2160
Seq/Len: 11.87

YGFA
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
2_I 119_A 2.648 1.00
42_S 49_T 2.618 1.00
36_T 64_Y 2.592 1.00
41_L 65_L 2.565 1.00
38_A 78_F 2.557 1.00
150_G 170_L 2.538 1.00
125_Q 163_V 2.516 1.00
38_A 113_L 2.488 1.00
62_R 80_N 2.454 1.00
36_T 62_R 2.405 1.00
154_D 177_S 2.374 1.00
121_D 125_Q 2.349 1.00
76_L 137_T 2.338 1.00
117_L 120_F 2.153 1.00
90_N 96_E 2.145 1.00
64_Y 110_L 2.01 1.00
21_A 47_L 1.981 1.00
25_M 114_I 1.907 1.00
49_T 151_Y 1.902 1.00
34_A 61_K 1.858 1.00
56_L 63_V 1.817 1.00
148_P 171_P 1.809 1.00
39_V 53_I 1.792 1.00
31_V 56_L 1.774 1.00
55_Q 59_A 1.747 1.00
18_G 153_H 1.744 1.00
122_E 178_K 1.739 1.00
10_T 13_Q 1.681 1.00
90_N 94_I 1.636 1.00
36_T 110_L 1.632 1.00
154_D 176_P 1.595 1.00
89_M 95_H 1.591 1.00
24_R 178_K 1.529 1.00
78_F 137_T 1.521 1.00
3_R 118_V 1.504 1.00
152_A 156_Q 1.485 1.00
65_L 81_Y 1.471 1.00
38_A 137_T 1.465 1.00
14_Q 18_G 1.463 1.00
31_V 59_A 1.444 1.00
122_E 157_L 1.429 1.00
147_Q 172_A 1.42 1.00
6_R 129_M 1.416 1.00
120_F 150_G 1.407 0.99
174_V 179_V 1.401 0.99
154_D 178_K 1.381 0.99
3_R 129_M 1.379 0.99
25_M 52_L 1.377 0.99
138_L 148_P 1.375 0.99
1_M 5_R 1.374 0.99
7_R 45_G 1.362 0.99
13_Q 17_M 1.353 0.99
67_V 79_L 1.351 0.99
14_Q 153_H 1.35 0.99
39_V 114_I 1.349 0.99
149_V 172_A 1.326 0.99
42_S 50_Q 1.316 0.99
28_Y 149_V 1.312 0.99
121_D 161_L 1.302 0.99
112_V 149_V 1.291 0.99
42_S 48_D 1.279 0.99
118_V 129_M 1.264 0.99
125_Q 169_P 1.26 0.99
121_D 160_K 1.254 0.99
119_A 127_L 1.237 0.98
154_D 157_L 1.228 0.98
4_Q 8_A 1.223 0.98
22_A 52_L 1.219 0.98
115_T 138_L 1.217 0.98
31_V 61_K 1.213 0.98
122_E 159_E 1.211 0.98
69_H 77_L 1.206 0.98
43_F 129_M 1.181 0.98
2_I 158_V 1.172 0.98
26_M 55_Q 1.162 0.97
28_Y 174_V 1.136 0.97
114_I 151_Y 1.124 0.97
17_M 153_H 1.122 0.97
88_V 98_K 1.118 0.96
117_L 157_L 1.116 0.96
81_Y 84_Q 1.113 0.96
28_Y 172_A 1.1 0.96
49_T 53_I 1.093 0.96
14_Q 45_G 1.083 0.96
38_A 64_Y 1.082 0.96
55_Q 58_R 1.081 0.95
117_L 170_L 1.079 0.95
52_L 151_Y 1.078 0.95
68_L 133_F 1.061 0.95
115_T 148_P 1.048 0.94
17_M 20_Q 1.044 0.94
148_P 170_L 1.041 0.94
7_R 44_D 1.038 0.94
120_F 156_Q 1.033 0.94
67_V 96_E 1.011 0.93
48_D 51_P 1.008 0.93
117_L 150_G 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2jcbA20.9781000.038Contact Map0.863
1ydmA30.9781000.043Contact Map0.831
1souA10.95051000.062Contact Map0.666
3hy3A10.9891000.076Contact Map0.857
1wkcA10.90111000.12Contact Map0.747
1sbqA20.84621000.184Contact Map0.831
1z7mA40.846212.10.948Contact Map0.12
2gdtA10.417640.958Contact Map0.372
2vrnA20.74733.50.959Contact Map0.4
3l18A20.71433.30.96Contact Map0.411

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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