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OPENSEQ.org

FOLX - D-erythro-7,8-dihydroneopterin triphosphate epimerase
UniProt: P0AC19 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14263
Length: 120 (116)
Sequences: 1398
Seq/Len: 12.05

FOLX
Paralog alert: 0.21 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: FOLB FOLX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
56_N 59_T 3.973 1.00
26_I 74_S 2.837 1.00
48_S 53_D 2.837 1.00
101_D 111_S 2.633 1.00
14_R 31_D 2.405 1.00
9_R 113_S 2.292 1.00
36_V 64_I 2.287 1.00
37_T 97_E 2.158 1.00
97_E 117_S 2.154 1.00
99_E 115_T 2.146 1.00
12_N 35_N 2.039 1.00
95_Y 117_S 1.998 1.00
26_I 72_R 1.941 1.00
38_I 60_V 1.911 1.00
12_N 110_D 1.893 1.00
87_A 93_V 1.892 1.00
39_H 95_Y 1.814 1.00
63_N 90_H 1.811 1.00
81_Q 85_D 1.686 1.00
73_F 82_D 1.677 1.00
15_L 61_T 1.643 1.00
21_I 51_I 1.588 1.00
63_N 86_I 1.51 1.00
78_K 82_D 1.504 1.00
36_V 98_V 1.5 1.00
66_Q 70_N 1.498 1.00
44_K 53_D 1.467 1.00
84_L 96_A 1.451 1.00
16_R 31_D 1.443 1.00
18_F 29_R 1.371 0.99
40_Y 55_L 1.37 0.99
68_V 79_L 1.368 0.99
24_E 28_N 1.349 0.99
67_H 86_I 1.317 0.99
19_I 32_I 1.301 0.99
97_E 115_T 1.288 0.99
50_D 53_D 1.276 0.99
56_N 62_K 1.275 0.99
24_E 27_N 1.269 0.99
84_L 116_L 1.209 0.98
73_F 78_K 1.198 0.98
73_F 79_L 1.187 0.98
35_N 101_D 1.183 0.98
81_Q 116_L 1.177 0.98
11_K 99_E 1.174 0.98
6_A 118_W 1.173 0.98
88_R 120_R 1.166 0.97
11_K 110_D 1.165 0.97
46_R 81_Q 1.154 0.97
60_V 87_A 1.147 0.97
16_R 29_R 1.14 0.97
99_E 113_S 1.138 0.97
7_I 115_T 1.137 0.97
7_I 37_T 1.115 0.96
31_D 104_H 1.092 0.96
38_I 93_V 1.092 0.96
80_T 116_L 1.075 0.95
11_K 111_S 1.035 0.94
62_K 66_Q 1.028 0.94
88_R 96_A 1.023 0.93
22_K 58_R 1.006 0.93
34_I 68_V 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4aeyA111000.088Contact Map0.496
1b9lA811000.093Contact Map0.752
3r2eA111000.101Contact Map0.731
3o1kA411000.103Contact Map0.91
2o90A10.96671000.103Contact Map0.739
1dhnA10.9751000.108Contact Map0.708
1sqlA1611000.109Contact Map0.921
1z9wA10.9751000.114Contact Map0.609
1nbuA50.9751000.116Contact Map0.865
3v9oA111000.123Contact Map0.623

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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