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OPENSEQ.org
DHPS - Dihydropteroate synthase
UniProt: P0AC13 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG50011
Length: 282 (272)
Sequences: 2107
Seq/Len: 7.75
DHPS
Paralog alert: 0.13 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
107_A 134_L 3.572 1.00
46_L 50_A 3.504 1.00
224_I 238_G 3.369 1.00
203_R 206_E 3.312 1.00
59_G 78_V 3.214 1.00
104_R 131_E 2.714 1.00
86_A 112_H 2.676 1.00
71_V 101_E 2.635 1.00
218_M 242_C 2.617 1.00
48_I 91_V 2.508 1.00
263_V 267_R 2.473 1.00
72_E 76_Q 2.405 1.00
205_A 249_Q 2.399 1.00
107_A 132_T 2.379 1.00
114_I 129_A 2.367 1.00
237_S 264_E 2.274 1.00
43_H 46_L 2.234 1.00
230_V 264_E 2.196 1.00
225_G 235_R 2.172 1.00
173_E 179_K 2.17 1.00
17_V 263_V 2.164 1.00
21_L 47_M 2.15 1.00
75_L 79_I 2.145 1.00
62_T 117_I 2.05 1.00
128_A 132_T 2.016 1.00
168_Q 171_R 2.014 1.00
216_V 246_A 1.995 1.00
113_I 137_C 1.932 1.00
243_A 262_T 1.921 1.00
73_E 76_Q 1.92 1.00
170_A 174_Q 1.897 1.00
19_G 47_M 1.883 1.00
239_S 243_A 1.848 1.00
236_L 240_L 1.824 1.00
152_P 196_H 1.815 1.00
105_E 108_K 1.783 1.00
44_A 85_I 1.738 1.00
236_L 258_D 1.731 1.00
222_S 226_Q 1.723 1.00
169_I 212_L 1.719 1.00
240_L 265_A 1.702 1.00
183_L 253_I 1.691 1.00
60_E 99_K 1.689 1.00
244_V 269_V 1.664 1.00
104_R 108_K 1.644 1.00
40_A 81_V 1.643 1.00
239_S 262_T 1.643 1.00
95_V 106_S 1.636 1.00
50_A 260_K 1.627 1.00
45_N 88_R 1.61 1.00
34_H 43_H 1.609 1.00
18_M 215_L 1.606 1.00
16_H 53_T 1.596 1.00
161_V 200_L 1.594 1.00
227_L 268_V 1.593 1.00
236_L 261_E 1.583 1.00
82_V 109_V 1.578 1.00
41_V 45_N 1.576 1.00
75_L 102_V 1.557 1.00
245_I 248_M 1.542 1.00
120_L 136_V 1.518 1.00
199_S 203_R 1.5 0.99
121_S 164_Y 1.483 0.99
247_A 266_M 1.47 0.99
142_Q 191_G 1.46 0.99
208_H 252_H 1.443 0.99
188_F 218_M 1.43 0.99
204_L 216_V 1.417 0.99
14_H 53_T 1.404 0.99
161_V 165_F 1.392 0.99
70_S 73_E 1.385 0.99
82_V 106_S 1.384 0.99
57_V 93_I 1.379 0.99
107_A 128_A 1.379 0.99
172_C 177_I 1.375 0.99
142_Q 152_P 1.349 0.99
97_T 103_I 1.324 0.98
33_T 233_S 1.315 0.98
75_L 105_E 1.306 0.98
104_R 132_T 1.297 0.98
108_K 132_T 1.294 0.98
170_A 173_E 1.292 0.98
45_N 89_F 1.279 0.98
21_L 55_I 1.274 0.98
194_L 223_M 1.273 0.98
245_I 272_T 1.267 0.98
244_V 265_A 1.262 0.98
42_K 45_N 1.255 0.98
119_S 138_L 1.255 0.98
216_V 251_A 1.246 0.97
193_N 196_H 1.245 0.97
103_I 125_A 1.238 0.97
240_L 262_T 1.235 0.97
162_N 207_F 1.23 0.97
194_L 227_L 1.222 0.97
143_G 148_M 1.219 0.97
36_S 39_D 1.216 0.97
156_D 159_A 1.216 0.97
50_A 261_E 1.213 0.97
198_Y 227_L 1.2 0.97
178_A 181_K 1.198 0.96
179_K 212_L 1.178 0.96
52_A 259_V 1.177 0.96
246_A 251_A 1.176 0.96
162_N 206_E 1.175 0.96
184_L 212_L 1.174 0.96
54_I 253_I 1.166 0.96
67_A 146_K 1.16 0.96
30_D 34_H 1.152 0.95
208_H 214_L 1.141 0.95
133_G 181_K 1.136 0.95
152_P 191_G 1.129 0.95
71_V 99_K 1.126 0.95
53_T 263_V 1.111 0.94
41_V 81_V 1.11 0.94
44_A 89_F 1.107 0.94
231_G 234_E 1.104 0.94
45_N 49_N 1.101 0.94
60_E 98_S 1.1 0.94
135_P 183_L 1.096 0.93
43_H 47_M 1.092 0.93
100_P 128_A 1.085 0.93
54_I 113_I 1.084 0.93
41_V 44_A 1.072 0.92
142_Q 164_Y 1.071 0.92
83_E 108_K 1.069 0.92
15_P 270_E 1.064 0.92
78_V 95_V 1.059 0.92
243_A 254_I 1.057 0.92
78_V 82_V 1.054 0.92
101_E 105_E 1.05 0.91
118_R 122_E 1.047 0.91
120_L 126_L 1.034 0.91
184_L 210_F 1.032 0.90
23_V 59_G 1.027 0.90
237_S 240_L 1.025 0.90
71_V 75_L 1.016 0.89
188_F 223_M 1.015 0.89
217_G 253_I 1.008 0.89
244_V 248_M 1.007 0.89
57_V 85_I 1.002 0.89
247_A 254_I 1 0.88
29_S 32_G 1 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2bmbA10.98231000.149Contact Map0.744
2vp8A20.99651000.162Contact Map0.784
2vefA20.97161000.172Contact Map0.815
2dqwA20.98581000.188Contact Map0.837
3tr9A40.98941000.198Contact Map0.799
1aj0A10.99651000.199Contact Map0.772
2y5sA20.98581000.201Contact Map0.785
1eyeA10.96451000.205Contact Map0.735
1tx2A20.9611000.222Contact Map0.829
3mcmA20.90781000.224Contact Map0.716
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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