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OPENSEQ.org

EXBD - Biopolymer transport protein ExbD
UniProt: P0ABV2 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10272
Length: 141 (135)
Sequences: 2588
Seq/Len: 19.17

EXBD
Paralog alert: 0.80 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: EXBD TOLR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
69_K 73_S 3.584 1.00
108_K 113_E 2.812 1.00
73_S 80_P 2.779 1.00
87_I 124_Q 2.51 1.00
112_Y 132_L 2.507 1.00
113_E 117_K 2.379 1.00
70_A 109_T 2.343 1.00
21_T 24_I 2.313 1.00
82_T 85_T 2.141 1.00
114_T 117_K 2.132 1.00
112_Y 115_L 2.017 1.00
79_D 89_A 1.941 1.00
69_K 75_F 1.857 1.00
68_V 118_V 1.841 1.00
90_L 122_L 1.805 1.00
19_N 29_V 1.772 1.00
74_M 118_V 1.696 1.00
89_A 92_A 1.67 1.00
116_M 120_D 1.656 1.00
31_L 34_F 1.649 1.00
94_T 127_Y 1.634 1.00
20_V 24_I 1.584 1.00
87_I 91_N 1.543 1.00
111_D 114_T 1.541 1.00
83_D 114_T 1.497 1.00
66_L 76_I 1.484 1.00
29_V 33_I 1.44 1.00
97_K 100_T 1.403 0.99
18_I 29_V 1.36 0.99
83_D 117_K 1.315 0.99
90_L 127_Y 1.314 0.99
27_M 30_L 1.306 0.99
49_L 112_Y 1.294 0.99
47_V 67_S 1.254 0.99
6_N 9_L 1.246 0.98
85_T 89_A 1.233 0.98
106_A 112_Y 1.213 0.98
21_T 29_V 1.196 0.98
75_F 80_P 1.195 0.98
102_I 127_Y 1.191 0.98
83_D 121_T 1.171 0.98
110_V 114_T 1.167 0.97
120_D 123_H 1.164 0.97
72_N 114_T 1.152 0.97
28_L 33_I 1.15 0.97
5_L 8_N 1.15 0.97
106_A 115_L 1.144 0.97
32_I 35_M 1.131 0.97
89_A 93_L 1.125 0.97
29_V 39_P 1.121 0.97
24_I 28_L 1.112 0.96
21_T 25_D 1.103 0.96
18_I 25_D 1.095 0.96
4_H 7_E 1.082 0.96
88_T 91_N 1.08 0.95
93_L 96_G 1.058 0.95
29_V 36_V 1.042 0.94
66_L 122_L 1.041 0.94
20_V 33_I 1.041 0.94
21_T 39_P 1.037 0.94
64_V 76_I 1.035 0.94
47_V 107_D 1.028 0.94
19_N 33_I 1.021 0.93
25_D 38_A 1.016 0.93
26_V 35_M 1.016 0.93
32_I 36_V 1.009 0.93
67_S 75_F 1.005 0.93
72_N 110_V 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2pfuA10.702199.70.474Contact Map0.459
2jwkA20.489499.20.619Contact Map0.541
2w3zA10.971646.60.895Contact Map0.254
3ghfA10.6028270.908Contact Map0.501
1hf2A40.560323.40.91Contact Map0.428
2jvfA10.588711.80.921Contact Map0.433
1uuqA10.638310.70.923Contact Map0.465
2obbA10.5399.60.925Contact Map0.385
3d3aA10.56749.10.925Contact Map0.607
4narA10.49657.60.928Contact Map0.391

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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