May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YIJE - Uncharacterized inner membrane transporter yiJE
UniProt: P0ABT8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11902
Length: 301 (282)
Sequences: 14097
Seq/Len: 49.99
YIJE
Paralog alert: 0.85 [within 20: 0.25] - ratio of genomes with paralogs
Cluster includes: EAMA RHTA YDDG YEDA YHBE YICL YIJE YTFF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
90_A 157_A 3.149 1.00
129_A 284_A 2.597 1.00
14_G 237_F 2.595 1.00
237_F 241_N 2.49 1.00
50_A 192_L 2.437 1.00
86_L 159_L 2.324 1.00
23_S 257_C 2.259 1.00
98_K 154_A 2.212 1.00
43_A 199_S 2.166 1.00
262_S 268_E 2.161 1.00
89_W 156_L 2.16 1.00
28_F 222_Y 2.109 1.00
113_F 169_I 2.034 1.00
109_W 161_G 1.998 1.00
15_L 238_V 1.99 1.00
237_F 240_K 1.988 1.00
100_A 258_G 1.988 1.00
155_M 159_L 1.937 1.00
214_P 218_W 1.914 1.00
50_A 195_A 1.892 1.00
47_I 195_A 1.877 1.00
30_K 268_E 1.864 1.00
120_E 172_K 1.843 1.00
23_S 261_F 1.835 1.00
48_F 224_A 1.824 1.00
224_A 229_A 1.822 1.00
29_M 88_Q 1.814 1.00
110_V 248_S 1.788 1.00
20_L 257_C 1.768 1.00
111_V 130_I 1.756 1.00
114_A 118_L 1.751 1.00
115_A 122_L 1.749 1.00
86_L 156_L 1.718 1.00
54_F 188_S 1.688 1.00
105_T 109_W 1.643 1.00
271_G 274_E 1.638 1.00
68_P 180_R 1.612 1.00
99_V 157_A 1.608 1.00
114_A 120_E 1.598 1.00
24_Y 222_Y 1.586 1.00
243_P 246_I 1.564 1.00
43_A 195_A 1.543 1.00
86_L 163_S 1.534 1.00
196_L 200_V 1.518 1.00
182_D 185_S 1.51 1.00
272_A 276_S 1.501 1.00
94_G 154_A 1.496 1.00
257_C 261_F 1.492 1.00
131_L 135_F 1.481 1.00
261_F 265_L 1.481 1.00
73_L 193_Y 1.479 1.00
113_F 166_A 1.47 1.00
123_R 126_Q 1.47 1.00
51_L 55_I 1.455 1.00
133_A 252_L 1.447 1.00
55_I 58_L 1.435 1.00
36_I 216_V 1.426 1.00
109_W 162_V 1.413 1.00
96_A 262_S 1.408 1.00
65_R 68_P 1.396 0.99
139_L 280_L 1.393 0.99
94_G 98_K 1.388 0.99
21_I 226_L 1.377 0.99
94_G 153_S 1.362 0.99
275_G 279_V 1.354 0.99
66_P 70_K 1.347 0.99
124_R 128_F 1.334 0.99
18_L 238_V 1.334 0.99
270_P 275_G 1.334 0.99
62_R 182_D 1.329 0.99
93_S 152_K 1.31 0.99
279_V 283_L 1.308 0.99
213_Q 216_V 1.304 0.99
32_V 41_F 1.304 0.99
41_F 223_S 1.295 0.99
89_W 93_S 1.288 0.99
70_K 74_A 1.284 0.99
14_G 234_L 1.284 0.99
109_W 165_G 1.276 0.99
76_A 193_Y 1.269 0.99
101_I 278_I 1.266 0.99
215_T 218_W 1.258 0.99
127_Y 131_L 1.252 0.99
50_A 188_S 1.252 0.99
27_I 261_F 1.247 0.99
113_F 117_F 1.244 0.98
286_A 290_R 1.242 0.98
139_L 273_V 1.231 0.98
140_V 277_G 1.228 0.98
171_A 236_L 1.224 0.98
97_G 259_V 1.223 0.98
13_S 17_V 1.216 0.98
91_L 99_V 1.212 0.98
67_T 70_K 1.211 0.98
37_G 40_D 1.208 0.98
42_T 198_M 1.206 0.98
74_A 170_V 1.205 0.98
129_A 288_V 1.202 0.98
96_A 266_L 1.191 0.98
110_V 244_A 1.189 0.98
54_F 58_L 1.188 0.98
161_G 165_G 1.185 0.98
122_L 127_Y 1.184 0.98
43_A 202_A 1.18 0.98
35_Y 216_V 1.179 0.98
52_V 229_A 1.176 0.98
165_G 169_I 1.166 0.97
24_Y 261_F 1.158 0.97
239_L 243_P 1.15 0.97
89_W 92_V 1.149 0.97
71_Y 170_V 1.148 0.97
28_F 219_A 1.145 0.97
221_A 224_A 1.138 0.97
218_W 222_Y 1.137 0.97
43_A 47_I 1.134 0.97
102_L 161_G 1.126 0.97
263_W 270_P 1.125 0.97
172_K 244_A 1.124 0.97
95_G 98_K 1.122 0.97
200_V 203_L 1.121 0.97
52_V 225_I 1.12 0.96
110_V 168_A 1.11 0.96
78_L 166_A 1.109 0.96
22_W 231_A 1.109 0.96
120_E 126_Q 1.102 0.96
19_T 23_S 1.099 0.96
115_A 121_R 1.099 0.96
108_F 133_A 1.097 0.96
151_M 155_M 1.096 0.96
31_Q 219_A 1.093 0.96
12_I 250_S 1.088 0.96
49_G 191_M 1.087 0.96
118_L 169_I 1.084 0.96
77_L 197_V 1.083 0.96
214_P 217_F 1.078 0.95
226_L 230_L 1.077 0.95
53_L 229_A 1.075 0.95
22_W 235_W 1.074 0.95
102_L 158_I 1.073 0.95
164_W 168_A 1.067 0.95
136_G 277_G 1.066 0.95
68_P 181_V 1.064 0.95
116_L 119_G 1.062 0.95
55_I 59_L 1.062 0.95
18_L 22_W 1.062 0.95
129_A 287_L 1.061 0.95
105_T 137_L 1.06 0.95
256_V 278_I 1.053 0.95
93_S 156_L 1.052 0.95
87_A 91_L 1.051 0.94
21_I 234_L 1.049 0.94
113_F 165_G 1.048 0.94
102_L 157_A 1.047 0.94
18_L 234_L 1.047 0.94
52_V 224_A 1.043 0.94
217_F 221_A 1.042 0.94
93_S 153_S 1.039 0.94
96_A 268_E 1.035 0.94
239_L 247_A 1.033 0.94
173_R 180_R 1.032 0.94
242_L 247_A 1.023 0.93
32_V 219_A 1.023 0.93
136_G 281_I 1.022 0.93
39_F 85_G 1.02 0.93
113_F 116_L 1.009 0.93
32_V 216_V 1.004 0.93
135_F 139_L 1.003 0.93
253_A 257_C 1.003 0.93
101_I 138_F 1.002 0.92
113_F 162_V 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i68A20.3754990.774Contact Map0.011
3b5dA20.362198.40.819Contact Map0.053
4lepA20.80735.70.957Contact Map0.189
4knfA50.20275.30.957Contact Map0.417
3wdoA10.73424.90.958Contact Map0.186
2xutA30.79074.30.959Contact Map0.145
2gfpA20.72763.80.96Contact Map0.138
4hg6A10.22263.70.96Contact Map0.159
2kluA10.14292.70.963Contact Map0.591
2kv5A10.09972.10.965Contact Map0.28
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.4649 seconds.