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OPENSEQ.org

DEOD - Purine nucleoside phosphorylase DeoD-type
UniProt: P0ABP8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10222
Length: 239 (232)
Sequences: 2275
Seq/Len: 9.81

DEOD
Paralog alert: 0.72 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: DEOD MTNN UDP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
190_A 197_A 3.509 1.00
92_C 203_V 3.212 1.00
131_D 196_K 3.139 1.00
78_I 195_A 3.131 1.00
85_K 196_K 2.79 1.00
36_D 52_T 2.651 1.00
108_M 151_V 2.409 1.00
109_G 129_I 2.398 1.00
27_K 31_E 2.311 1.00
99_V 150_R 2.304 1.00
183_A 199_T 2.265 1.00
139_V 151_V 2.252 1.00
139_V 143_K 2.176 1.00
134_M 198_L 2.165 1.00
107_G 154_L 2.088 1.00
136_R 140_D 2.08 1.00
15_D 84_K 2.066 1.00
9_E 12_D 1.989 1.00
52_T 57_K 1.984 1.00
75_K 193_F 1.925 1.00
155_F 176_I 1.903 1.00
169_D 173_K 1.889 1.00
42_N 47_L 1.888 1.00
135_V 198_L 1.885 1.00
96_L 177_L 1.842 1.00
38_R 50_T 1.82 1.00
106_I 135_V 1.819 1.00
105_V 178_G 1.818 1.00
109_G 153_N 1.801 1.00
84_K 195_A 1.792 1.00
138_A 198_L 1.749 1.00
39_E 42_N 1.743 1.00
12_D 38_R 1.726 1.00
19_M 86_I 1.707 1.00
23_P 62_G 1.699 1.00
67_I 156_S 1.671 1.00
67_I 185_G 1.659 1.00
132_F 136_R 1.611 1.00
92_C 178_G 1.575 1.00
100_K 103_D 1.527 1.00
74_T 86_I 1.527 1.00
19_M 63_H 1.503 1.00
140_D 143_K 1.483 1.00
16_V 85_K 1.481 1.00
166_E 169_D 1.475 1.00
54_K 231_E 1.472 1.00
135_V 151_V 1.469 1.00
154_L 178_G 1.464 1.00
214_T 217_E 1.461 1.00
109_G 127_A 1.441 1.00
180_E 183_A 1.429 1.00
75_K 79_T 1.404 0.99
79_T 193_F 1.397 0.99
136_R 139_V 1.393 0.99
106_I 149_A 1.377 0.99
21_G 25_R 1.377 0.99
223_N 226_I 1.373 0.99
106_I 139_V 1.34 0.99
105_V 203_V 1.31 0.99
113_D 157_A 1.302 0.99
40_V 61_M 1.299 0.99
86_I 190_A 1.275 0.99
136_R 143_K 1.269 0.99
29_I 60_V 1.269 0.99
112_T 188_G 1.25 0.98
133_D 196_K 1.249 0.98
224_D 227_K 1.234 0.98
112_T 184_A 1.232 0.98
40_V 50_T 1.231 0.98
70_C 185_G 1.23 0.98
86_I 195_A 1.225 0.98
110_A 187_Y 1.225 0.98
180_E 199_T 1.216 0.98
96_L 99_V 1.203 0.98
156_S 183_A 1.19 0.98
150_R 177_L 1.189 0.98
17_V 83_V 1.179 0.98
78_I 86_I 1.173 0.97
105_V 177_L 1.169 0.97
50_T 59_S 1.167 0.97
110_A 183_A 1.164 0.97
206_H 209_T 1.155 0.97
39_E 47_L 1.154 0.97
23_P 30_A 1.143 0.97
98_H 150_R 1.134 0.97
74_T 189_V 1.132 0.97
46_M 62_G 1.116 0.96
28_Y 223_N 1.115 0.96
88_R 186_I 1.113 0.96
223_N 227_K 1.105 0.96
132_F 139_V 1.097 0.96
35_E 52_T 1.094 0.96
111_C 127_A 1.091 0.96
52_T 55_G 1.087 0.95
111_C 155_F 1.083 0.95
143_K 148_D 1.074 0.95
94_A 206_H 1.066 0.95
103_D 150_R 1.062 0.95
16_V 233_V 1.059 0.95
107_G 130_A 1.055 0.94
48_G 59_S 1.053 0.94
169_D 172_E 1.045 0.94
115_K 120_R 1.045 0.94
137_N 141_A 1.04 0.94
61_M 73_Y 1.031 0.94
95_V 179_V 1.029 0.93
170_V 173_K 1.028 0.93
104_V 228_I 1.028 0.93
16_V 56_R 1.025 0.93
50_T 57_K 1.024 0.93
187_Y 197_A 1.019 0.93
85_K 131_D 1.019 0.93
71_S 189_V 1.014 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4m3nA30.97491000.202Contact Map0.866
3bjeA20.98331000.205Contact Map0.737
4ldnA111000.208Contact Map0.749
4lkrA10.98331000.211Contact Map0.827
4m7wA30.98741000.215Contact Map0.876
1odkA60.98331000.216Contact Map0.84
1vhwA611000.221Contact Map0.831
3u40A60.97491000.226Contact Map0.862
3phcA60.98741000.234Contact Map0.791
3uawA10.98331000.237Contact Map0.845

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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