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OPENSEQ.org
FTSW - Lipid II flippase FtsW
UniProt: P0ABG4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10344
Length: 414 (362)
Sequences: 3800
Seq/Len: 10.50
FTSW
Paralog alert: 0.88 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: FTSW RODA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
326_A 349_G 3.834 1.00
45_D 325_R 3.828 1.00
326_A 394_L 3.301 1.00
345_A 394_L 3.216 1.00
140_D 143_L 2.94 1.00
104_M 341_S 2.878 1.00
256_D 259_G 2.696 1.00
210_A 350_I 2.605 1.00
51_L 321_F 2.544 1.00
304_G 312_V 2.461 1.00
56_A 89_L 2.414 1.00
271_F 304_G 2.398 1.00
348_I 394_L 2.393 1.00
51_L 322_V 2.372 1.00
252_N 255_E 2.3 1.00
131_S 136_S 2.294 1.00
92_A 388_S 2.284 1.00
118_S 155_S 2.261 1.00
293_E 296_T 2.232 1.00
99_T 389_T 2.216 1.00
52_T 391_I 2.186 1.00
361_G 367_L 2.125 1.00
77_D 83_K 2.121 1.00
281_L 307_L 2.086 1.00
203_V 372_L 2.067 1.00
211_M 347_S 2.053 1.00
124_I 128_V 2.019 1.00
118_S 152_T 2.007 1.00
158_C 344_L 1.984 1.00
376_L 387_M 1.949 1.00
303_I 315_A 1.944 1.00
214_L 346_C 1.933 1.00
362_A 369_T 1.933 1.00
376_L 391_I 1.929 1.00
341_S 397_I 1.91 1.00
300_F 312_V 1.9 1.00
62_M 303_I 1.896 1.00
313_V 317_L 1.872 1.00
116_L 120_I 1.87 1.00
189_A 201_V 1.856 1.00
316_L 360_V 1.855 1.00
114_M 155_S 1.854 1.00
96_A 395_L 1.842 1.00
190_V 194_A 1.815 1.00
356_A 360_V 1.784 1.00
62_M 307_L 1.766 1.00
326_A 345_A 1.762 1.00
157_F 347_S 1.721 1.00
137_R 149_A 1.713 1.00
277_W 310_V 1.712 1.00
108_Q 340_F 1.704 1.00
345_A 397_I 1.704 1.00
149_A 200_T 1.679 1.00
284_S 302_I 1.672 1.00
60_F 82_A 1.639 1.00
300_F 360_V 1.626 1.00
254_W 265_T 1.623 1.00
207_T 351_W 1.598 1.00
264_L 369_T 1.577 1.00
86_G 90_I 1.572 1.00
266_Q 286_Q 1.569 1.00
123_M 127_V 1.561 1.00
65_S 306_E 1.554 1.00
133_K 293_E 1.542 1.00
174_N 177_G 1.539 1.00
303_I 377_I 1.534 1.00
323_A 353_S 1.517 1.00
104_M 396_R 1.506 1.00
55_L 377_I 1.503 1.00
55_L 315_A 1.472 1.00
140_D 145_R 1.466 1.00
60_F 86_G 1.451 1.00
58_I 303_I 1.449 1.00
95_L 389_T 1.448 1.00
156_L 204_L 1.444 1.00
62_M 299_I 1.436 1.00
185_I 208_T 1.42 1.00
267_S 363_A 1.416 1.00
48_L 322_V 1.414 1.00
211_M 343_F 1.411 1.00
58_I 318_M 1.41 1.00
309_Y 313_V 1.404 0.99
66_A 302_I 1.395 0.99
396_R 400_E 1.389 0.99
100_L 392_M 1.383 0.99
88_Y 381_G 1.381 0.99
51_L 318_M 1.359 0.99
333_A 397_I 1.358 0.99
394_L 397_I 1.351 0.99
269_M 286_Q 1.347 0.99
125_V 148_P 1.344 0.99
110_Y 113_T 1.33 0.99
56_A 388_S 1.329 0.99
200_T 373_T 1.328 0.99
349_G 394_L 1.325 0.99
164_L 211_M 1.324 0.99
120_I 124_I 1.307 0.99
373_T 383_S 1.296 0.99
146_I 151_L 1.296 0.99
323_A 356_A 1.294 0.99
257_P 265_T 1.292 0.99
298_F 369_T 1.279 0.99
100_L 396_R 1.278 0.99
160_I 208_T 1.274 0.99
323_A 349_G 1.266 0.99
90_I 94_I 1.262 0.99
276_L 310_V 1.258 0.99
157_F 207_T 1.254 0.99
80_F 84_R 1.251 0.99
267_S 301_A 1.25 0.99
316_L 356_A 1.247 0.99
122_L 152_T 1.244 0.98
299_I 303_I 1.244 0.98
276_L 309_Y 1.242 0.98
344_L 397_I 1.238 0.98
58_I 315_A 1.237 0.98
241_P 244_I 1.237 0.98
296_T 379_Y 1.23 0.98
60_F 85_D 1.228 0.98
125_V 139_I 1.228 0.98
218_K 221_Q 1.227 0.98
245_R 260_S 1.221 0.98
122_L 125_V 1.207 0.98
240_E 243_R 1.196 0.98
161_A 211_M 1.193 0.98
96_A 392_M 1.192 0.98
107_W 393_M 1.192 0.98
329_I 345_A 1.191 0.98
150_E 153_K 1.182 0.98
264_L 365_G 1.177 0.98
279_Q 285_V 1.176 0.98
199_G 370_K 1.171 0.98
106_F 110_Y 1.165 0.97
273_R 279_Q 1.16 0.97
330_G 345_A 1.159 0.97
335_E 338_H 1.158 0.97
89_L 384_L 1.156 0.97
374_L 377_I 1.155 0.97
124_I 139_I 1.148 0.97
104_M 397_I 1.146 0.97
291_L 301_A 1.146 0.97
348_I 390_A 1.143 0.97
119_I 123_M 1.139 0.97
253_P 261_G 1.139 0.97
81_F 295_H 1.132 0.97
48_L 329_I 1.128 0.97
130_S 140_D 1.127 0.97
52_T 388_S 1.125 0.97
94_I 98_I 1.124 0.97
113_T 117_G 1.121 0.97
157_F 211_M 1.112 0.96
328_S 332_K 1.112 0.96
351_W 390_A 1.11 0.96
319_V 356_A 1.108 0.96
199_G 362_A 1.103 0.96
111_S 340_F 1.102 0.96
61_I 281_L 1.101 0.96
186_L 190_V 1.099 0.96
256_D 260_S 1.097 0.96
151_L 386_I 1.091 0.96
93_F 97_I 1.09 0.96
360_V 364_A 1.09 0.96
256_D 261_G 1.089 0.96
83_K 86_G 1.089 0.96
254_W 268_L 1.087 0.96
330_G 346_C 1.082 0.96
64_T 82_A 1.081 0.95
267_S 298_F 1.079 0.95
137_R 199_G 1.079 0.95
85_D 88_Y 1.078 0.95
392_M 396_R 1.07 0.95
214_L 350_I 1.066 0.95
193_L 201_V 1.064 0.95
177_G 180_K 1.053 0.95
102_L 107_W 1.05 0.94
266_Q 269_M 1.048 0.94
249_A 260_S 1.048 0.94
162_N 166_R 1.044 0.94
207_T 210_A 1.035 0.94
315_A 377_I 1.034 0.94
261_G 265_T 1.034 0.94
312_V 364_A 1.033 0.94
82_A 86_G 1.025 0.93
355_Q 373_T 1.021 0.93
338_H 341_S 1.017 0.93
92_A 392_M 1.013 0.93
124_I 127_V 1.01 0.93
83_K 87_V 1.009 0.93
362_A 367_L 1.007 0.93
263_Q 267_S 1.002 0.92
47_T 321_F 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
4h44E10.07493.60.983Contact Map0.164
4f4sA100.14733.50.983Contact Map0.213
2k9jB10.10142.80.984Contact Map0.252
2xndJ80.13772.70.984Contact Map0.012
2looA10.13532.20.985Contact Map0
4i7zE10.07732.10.985Contact Map0.246
3arcZ20.12081.80.985Contact Map0.01
2l6wA20.0871.80.985Contact Map0.194
4ftgE10.04591.80.985Contact Map
1ko7A20.15221.70.986Contact Map
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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