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OPENSEQ.org
ARSB - Arsenical pump membrane protein
UniProt: P0AB93 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12236
Length: 429 (422)
Sequences: 4148
Seq/Len: 9.83
ARSB
Paralog alert: 0.72 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: ARSB CITT TTDT YBHI YBIR YFJV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
303_E 307_G 3.75 1.00
72_E 273_K 3.715 1.00
42_H 45_D 3.621 1.00
90_R 93_L 3.587 1.00
45_D 298_N 3.178 1.00
398_S 401_Y 2.603 1.00
234_L 255_G 2.571 1.00
214_P 217_A 2.408 1.00
140_V 386_W 2.389 1.00
102_G 118_L 2.317 1.00
272_G 276_R 2.259 1.00
155_I 165_A 2.224 1.00
61_I 283_V 2.178 1.00
171_G 174_E 2.16 1.00
82_H 86_W 2.086 1.00
104_A 108_L 2.071 1.00
225_K 229_V 2.047 1.00
11_T 31_G 2.038 1.00
400_G 404_R 2.031 1.00
141_M 145_F 2.027 1.00
411_L 415_F 2.007 1.00
2_L 6_A 1.983 1.00
270_N 273_K 1.951 1.00
82_H 85_R 1.947 1.00
98_I 122_V 1.917 1.00
316_G 319_A 1.858 1.00
173_R 177_S 1.828 1.00
401_Y 404_R 1.816 1.00
65_I 256_A 1.813 1.00
5_G 301_L 1.806 1.00
96_T 191_L 1.784 1.00
176_A 180_V 1.757 1.00
333_S 410_T 1.751 1.00
329_A 410_T 1.74 1.00
10_L 14_L 1.715 1.00
196_L 199_R 1.704 1.00
192_V 196_L 1.703 1.00
7_I 34_L 1.689 1.00
213_S 216_E 1.681 1.00
222_A 226_T 1.672 1.00
78_W 224_F 1.667 1.00
61_I 65_I 1.665 1.00
146_I 150_A 1.664 1.00
35_A 295_G 1.662 1.00
364_A 421_L 1.649 1.00
14_L 17_W 1.642 1.00
68_L 71_D 1.637 1.00
106_A 150_A 1.628 1.00
189_A 416_V 1.617 1.00
144_G 386_W 1.587 1.00
177_S 181_P 1.585 1.00
52_I 287_L 1.585 1.00
153_P 180_V 1.578 1.00
377_P 387_L 1.566 1.00
403_F 407_I 1.553 1.00
304_Y 308_V 1.535 1.00
308_V 312_L 1.53 1.00
150_A 154_L 1.492 1.00
156_V 172_F 1.488 1.00
7_I 31_G 1.483 1.00
92_R 195_H 1.482 1.00
78_W 82_H 1.479 1.00
419_A 423_L 1.473 1.00
137_L 401_Y 1.464 1.00
230_V 255_G 1.459 1.00
14_L 27_S 1.458 1.00
174_E 359_E 1.454 1.00
189_A 412_P 1.446 1.00
240_V 243_P 1.425 1.00
184_I 188_V 1.422 1.00
153_P 183_D 1.415 1.00
236_V 240_V 1.414 0.99
122_V 143_A 1.413 0.99
330_F 334_I 1.412 0.99
13_V 17_W 1.409 0.99
174_E 177_S 1.405 0.99
332_S 337_N 1.402 0.99
11_T 27_S 1.397 0.99
296_L 301_L 1.391 0.99
88_N 93_L 1.384 0.99
186_A 413_V 1.383 0.99
8_F 296_L 1.381 0.99
400_G 403_F 1.381 0.99
328_T 344_G 1.378 0.99
25_G 281_Q 1.376 0.99
149_T 186_A 1.37 0.99
69_L 227_G 1.367 0.99
23_G 27_S 1.365 0.99
151_S 158_N 1.362 0.99
110_A 113_G 1.362 0.99
7_I 35_A 1.359 0.99
102_G 147_A 1.352 0.99
364_A 368_G 1.352 0.99
326_F 414_L 1.352 0.99
182_V 416_V 1.349 0.99
32_A 288_G 1.349 0.99
106_A 111_N 1.347 0.99
99_V 146_I 1.338 0.99
69_L 259_L 1.331 0.99
307_G 310_N 1.326 0.99
240_V 244_L 1.325 0.99
193_M 412_P 1.317 0.99
160_V 380_S 1.315 0.99
151_S 154_L 1.314 0.99
160_V 338_M 1.311 0.99
221_P 225_K 1.308 0.99
160_V 370_D 1.298 0.99
87_G 97_W 1.293 0.99
151_S 157_S 1.29 0.99
213_S 217_A 1.288 0.99
10_L 34_L 1.281 0.99
193_M 196_L 1.26 0.99
78_W 81_L 1.256 0.99
226_T 268_A 1.252 0.98
326_F 330_F 1.251 0.98
192_V 195_H 1.249 0.98
407_I 411_L 1.247 0.98
150_A 157_S 1.233 0.98
229_V 233_L 1.232 0.98
228_W 232_L 1.226 0.98
77_E 81_L 1.223 0.98
66_I 234_L 1.217 0.98
110_A 114_A 1.217 0.98
331_L 340_T 1.216 0.98
230_V 258_I 1.214 0.98
415_F 419_A 1.21 0.98
149_T 190_T 1.21 0.98
111_N 151_S 1.207 0.98
299_A 346_L 1.205 0.98
33_V 257_L 1.198 0.98
185_A 189_A 1.187 0.98
296_L 302_T 1.186 0.98
159_L 338_M 1.184 0.98
286_S 338_M 1.183 0.98
366_V 369_C 1.18 0.98
341_V 369_C 1.179 0.98
56_A 60_F 1.179 0.98
144_G 148_D 1.169 0.97
325_G 368_G 1.167 0.97
294_Y 298_N 1.167 0.97
3_L 38_T 1.16 0.97
60_F 338_M 1.158 0.97
307_G 311_V 1.157 0.97
140_V 143_A 1.155 0.97
103_A 183_D 1.152 0.97
375_I 410_T 1.15 0.97
112_D 158_N 1.149 0.97
127_L 393_K 1.148 0.97
175_Y 238_F 1.147 0.97
144_G 382_A 1.146 0.97
330_F 407_I 1.129 0.97
232_L 236_V 1.125 0.96
154_L 157_S 1.123 0.96
4_A 295_G 1.116 0.96
233_L 237_G 1.116 0.96
15_V 289_M 1.113 0.96
150_A 187_I 1.108 0.96
226_T 262_V 1.108 0.96
14_L 30_L 1.105 0.96
366_V 370_D 1.105 0.96
348_I 365_N 1.104 0.96
375_I 407_I 1.098 0.96
297_R 303_E 1.098 0.96
100_L 104_A 1.097 0.96
233_L 258_I 1.088 0.96
163_V 342_L 1.086 0.95
414_L 418_L 1.084 0.95
181_P 184_I 1.083 0.95
401_Y 405_T 1.081 0.95
36_L 46_I 1.08 0.95
68_L 278_A 1.079 0.95
37_V 254_V 1.079 0.95
338_M 380_S 1.078 0.95
6_A 10_L 1.072 0.95
145_F 333_S 1.072 0.95
32_A 47_P 1.071 0.95
322_L 418_L 1.069 0.95
337_N 379_G 1.06 0.95
15_V 28_A 1.06 0.95
114_A 147_A 1.059 0.95
374_K 383_T 1.052 0.94
9_V 13_V 1.048 0.94
212_K 216_E 1.046 0.94
61_I 278_A 1.045 0.94
223_T 226_T 1.037 0.94
28_A 288_G 1.036 0.94
5_G 9_V 1.034 0.94
25_G 275_L 1.034 0.94
62_A 256_A 1.033 0.94
59_A 111_N 1.033 0.94
288_G 292_V 1.03 0.93
20_K 23_G 1.027 0.93
62_A 252_A 1.025 0.93
66_I 256_A 1.024 0.93
24_I 28_A 1.024 0.93
377_P 384_L 1.024 0.93
73_S 227_G 1.022 0.93
241_L 246_I 1.018 0.93
7_I 11_T 1.017 0.93
80_A 84_S 1.017 0.93
369_C 372_G 1.014 0.93
175_Y 366_V 1.012 0.93
57_T 283_V 1.011 0.93
185_A 416_V 1.004 0.92
238_F 252_A 1.004 0.92
111_N 332_S 1.003 0.92
194_L 198_F 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f35D40.94871000.381Contact Map0.647
3ne5A10.29845.50.972Contact Map0.241
2rddB10.08622.60.976Contact Map0.686
2kncA10.11891.50.979Contact Map0.377
3qe7A10.49881.20.98Contact Map0.412
2j5dA20.10021.10.98Contact Map0.825
4k0jA60.417210.981Contact Map0.289
2k1aA10.097910.981Contact Map0.629
2imuA10.10020.90.982Contact Map0.405
4g1uA20.42660.90.982Contact Map0.23
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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