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OPENSEQ.org
YBHH - Putative isomerase YbhH
UniProt: P0AAV8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13664
Length: 350 (350)
Sequences: 559
Seq/Len: 1.60
YBHH
Paralog alert: 0.11 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
202_P 205_Y 4.315 1.00
121_I 132_A 3.992 1.00
183_Y 188_P 3.233 1.00
18_F 99_G 2.614 1.00
19_L 38_I 2.256 0.99
202_P 298_Q 2.243 0.99
179_N 182_D 2.243 0.99
97_L 161_L 2.151 0.99
204_E 256_P 2.149 0.99
148_R 155_T 2.113 0.99
254_I 296_T 2.09 0.99
17_A 38_I 2.04 0.99
29_T 33_K 2.011 0.98
76_L 124_V 1.99 0.98
63_I 103_F 1.972 0.98
38_I 347_V 1.906 0.97
286_S 291_L 1.898 0.97
236_K 243_V 1.881 0.97
175_F 180_Q 1.845 0.97
175_F 294_T 1.792 0.96
344_S 348_Y 1.785 0.96
122_R 127_G 1.757 0.95
199_V 230_I 1.73 0.95
222_A 226_R 1.712 0.94
227_I 268_F 1.695 0.94
265_V 277_L 1.677 0.94
97_L 102_A 1.674 0.94
71_A 129_F 1.651 0.93
22_E 65_R 1.642 0.93
73_V 101_G 1.615 0.92
208_K 223_L 1.603 0.91
201_I 230_I 1.597 0.91
309_N 316_A 1.54 0.89
36_M 85_Q 1.529 0.89
306_G 322_S 1.526 0.89
204_E 258_Q 1.503 0.88
279_I 335_V 1.498 0.87
133_D 162_T 1.496 0.87
201_I 206_L 1.493 0.87
117_T 136_T 1.493 0.87
4_I 34_I 1.489 0.87
55_P 269_M 1.483 0.87
188_P 298_Q 1.481 0.87
56_L 275_R 1.481 0.87
106_E 341_K 1.471 0.86
77_F 98_S 1.463 0.86
60_V 77_F 1.46 0.85
11_G 99_G 1.45 0.85
114_S 136_T 1.428 0.84
20_L 107_N 1.42 0.83
276_A 321_L 1.395 0.82
41_S 58_S 1.368 0.80
77_F 100_V 1.356 0.79
200_I 296_T 1.354 0.79
267_Y 278_A 1.353 0.79
78_A 89_T 1.353 0.79
68_D 122_R 1.35 0.79
74_D 122_R 1.345 0.78
211_Y 255_S 1.333 0.77
175_F 190_T 1.328 0.77
216_E 286_S 1.306 0.75
15_R 96_M 1.304 0.75
208_K 220_D 1.302 0.75
73_V 119_V 1.293 0.74
60_V 229_S 1.292 0.74
184_F 234_A 1.291 0.74
214_P 275_R 1.29 0.74
35_L 57_T 1.288 0.74
195_A 284_A 1.288 0.74
105_I 134_V 1.287 0.74
180_Q 294_T 1.283 0.74
191_C 238_M 1.282 0.74
173_K 291_L 1.282 0.74
187_V 201_I 1.282 0.74
184_F 233_Q 1.281 0.73
117_T 169_T 1.279 0.73
114_S 138_N 1.276 0.73
229_S 233_Q 1.263 0.72
181_I 188_P 1.258 0.71
277_L 285_I 1.248 0.71
147_A 336_I 1.243 0.70
255_S 264_N 1.229 0.69
64_S 124_V 1.22 0.68
7_V 341_K 1.218 0.68
45_L 54_N 1.217 0.68
278_A 281_G 1.217 0.68
130_I 194_M 1.216 0.68
78_A 88_D 1.206 0.67
70_R 229_S 1.197 0.66
201_I 226_R 1.195 0.66
200_I 254_I 1.195 0.66
211_Y 258_Q 1.189 0.65
159_V 209_T 1.188 0.65
35_L 100_V 1.187 0.65
52_G 103_F 1.186 0.65
118_R 133_D 1.185 0.65
168_G 171_T 1.183 0.65
233_Q 237_A 1.181 0.64
63_I 102_A 1.171 0.63
161_L 168_G 1.17 0.63
107_N 159_V 1.169 0.63
85_Q 138_N 1.168 0.63
250_K 282_A 1.166 0.63
7_V 107_N 1.162 0.63
195_A 278_A 1.159 0.62
123_N 171_T 1.157 0.62
190_T 284_A 1.155 0.62
106_E 137_P 1.152 0.62
35_L 77_F 1.149 0.61
34_I 349_L 1.147 0.61
29_T 186_D 1.141 0.61
61_A 96_M 1.14 0.60
16_G 99_G 1.139 0.60
78_A 87_V 1.139 0.60
166_A 269_M 1.138 0.60
32_D 89_T 1.128 0.59
45_L 214_P 1.127 0.59
187_V 202_P 1.119 0.58
218_D 273_C 1.119 0.58
324_E 327_D 1.119 0.58
56_L 269_M 1.114 0.58
335_V 343_F 1.112 0.58
21_A 64_S 1.104 0.57
263_I 299_I 1.102 0.57
267_Y 281_G 1.101 0.56
50_I 342_I 1.099 0.56
185_D 229_S 1.097 0.56
103_F 107_N 1.096 0.56
26_E 222_A 1.094 0.56
39_M 60_V 1.093 0.56
54_N 275_R 1.09 0.55
82_V 218_D 1.089 0.55
89_T 135_Q 1.088 0.55
91_P 247_V 1.087 0.55
261_G 264_N 1.086 0.55
181_I 291_L 1.084 0.55
106_E 143_Y 1.08 0.54
261_G 311_E 1.076 0.54
324_E 329_T 1.067 0.53
30_Q 342_I 1.067 0.53
184_F 191_C 1.067 0.53
107_N 341_K 1.066 0.53
85_Q 201_I 1.066 0.53
70_R 256_P 1.065 0.53
250_K 269_M 1.052 0.51
133_D 332_R 1.052 0.51
46_E 98_S 1.049 0.51
91_P 270_P 1.047 0.51
150_D 312_H 1.046 0.51
42_G 85_Q 1.04 0.50
255_S 258_Q 1.04 0.50
184_F 237_A 1.036 0.50
220_D 276_A 1.03 0.49
217_L 268_F 1.029 0.49
68_D 102_A 1.029 0.49
175_F 192_I 1.027 0.49
41_S 83_H 1.023 0.48
216_E 342_I 1.023 0.48
168_G 193_D 1.022 0.48
177_T 182_D 1.022 0.48
324_E 331_L 1.018 0.48
215_A 219_A 1.016 0.48
273_C 343_F 1.013 0.47
322_S 343_F 1.009 0.47
56_L 278_A 1.009 0.47
132_A 161_L 1.009 0.47
134_V 141_V 1.004 0.46
278_A 283_I 1.001 0.46
3_K 348_Y 1 0.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2pw0A211000.16Contact Map0.569
3g7kA40.99431000.336Contact Map0.61
1w61A20.882999.90.829Contact Map0.275
4lb0A20.868699.70.867Contact Map0.277
4k8lA10.865799.70.869Contact Map0.313
2otnA20.78960.953Contact Map0.361
1xubA10.745795.90.953Contact Map0.169
3ednA20.797195.90.953Contact Map0.305
4juuA20.825795.40.955Contact Map0.223
3fveA10.751492.60.96Contact Map0.328
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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