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OPENSEQ.org

FRMR - Transcriptional repressor FrmR
UniProt: P0AAP3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13296
Length: 91 (91)
Sequences: 1343
Seq/Len: 14.76

FRMR
Paralog alert: 0.46 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FRMR RCNR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
19_R 23_D 5.202 1.00
16_R 26_E 3.465 1.00
27_R 31_G 2.774 1.00
9_K 13_T 2.734 1.00
22_I 45_V 2.495 1.00
25_L 45_V 2.477 1.00
18_I 22_I 2.048 1.00
13_T 17_R 1.804 1.00
34_E 37_A 1.735 1.00
7_E 10_K 1.638 1.00
8_K 32_D 1.574 1.00
12_L 26_E 1.519 1.00
14_R 48_A 1.513 1.00
10_K 13_T 1.494 1.00
45_V 49_A 1.435 1.00
15_V 29_L 1.405 0.99
18_I 52_L 1.389 0.99
15_V 22_I 1.378 0.99
17_R 48_A 1.349 0.99
46_R 50_N 1.343 0.99
34_E 81_D 1.318 0.99
5_P 32_D 1.315 0.99
17_R 21_Q 1.304 0.99
41_Q 44_A 1.259 0.99
42_I 53_M 1.203 0.98
11_V 29_L 1.194 0.98
18_I 48_A 1.186 0.98
36_R 81_D 1.185 0.98
12_L 30_E 1.178 0.98
19_R 26_E 1.156 0.97
42_I 56_V 1.153 0.97
15_V 52_L 1.146 0.97
21_Q 24_A 1.101 0.96
80_D 84_E 1.099 0.96
53_M 89_Y 1.068 0.95
24_A 28_S 1.057 0.95
76_S 80_D 1.052 0.95
71_Y 74_E 1.051 0.94
19_R 22_I 1.028 0.94
59_S 63_E 1.025 0.93
67_R 72_S 1.018 0.93
33_A 37_A 1.016 0.93
58_E 62_R 1.01 0.93
49_A 53_M 1.002 0.92
42_I 52_L 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2hh7A10.9891000.045Contact Map0.453
4adzA211000.05Contact Map0.55
3aaiA40.96799.90.099Contact Map0.631
2fb5A30.901168.10.853Contact Map0.371
1gaxA20.747313.80.901Contact Map0.219
3frtA20.98910.30.907Contact Map0.205
3hglA10.82429.60.908Contact Map0.33
4l6yA20.9679.20.909Contact Map0.29
2gd5A40.9896.70.914Contact Map0.249
3swyA30.241860.916Contact Map0.692

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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