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OPENSEQ.org

HYBG - Hydrogenase-2 operon protein HybG
UniProt: P0AAM7 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11805
Length: 82 (75)
Sequences: 657
Seq/Len: 8.76

HYBG
Paralog alert: 0.48 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: HYBG HYPC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
62_E 66_K 2.768 1.00
9_V 43_D 2.568 1.00
7_G 24_V 2.344 1.00
67_A 70_D 2.085 1.00
63_D 67_A 1.99 1.00
66_K 70_D 1.985 1.00
21_Q 28_K 1.948 1.00
20_A 33_I 1.9 1.00
68_T 72_L 1.838 1.00
47_Q 59_I 1.721 1.00
11_A 21_Q 1.648 1.00
10_L 28_K 1.637 1.00
8_Q 23_E 1.483 1.00
65_A 69_L 1.48 1.00
32_N 35_L 1.42 0.99
7_G 51_V 1.383 0.99
8_Q 48_W 1.378 0.99
21_Q 30_D 1.354 0.99
50_L 61_D 1.289 0.98
8_Q 62_E 1.287 0.98
64_E 67_A 1.265 0.98
25_C 73_R 1.246 0.98
27_I 53_V 1.222 0.98
31_V 56_A 1.204 0.97
36_I 59_I 1.199 0.97
23_E 26_G 1.188 0.97
53_V 56_A 1.149 0.96
7_G 22_V 1.134 0.96
32_N 55_F 1.102 0.95
58_S 64_E 1.093 0.95
71_A 74_Q 1.09 0.95
53_V 58_S 1.084 0.94
22_V 31_V 1.077 0.94
2_C 6_P 1.067 0.94
9_V 20_A 1.063 0.94
7_G 23_E 1.046 0.93
39_G 43_D 1.042 0.93
50_L 60_I 1.041 0.93
29_R 72_L 1.025 0.92
41_P 59_I 1.012 0.91
12_V 45_L 1.01 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ot2A10.963499.90.128Contact Map0.538
3d3rA20.93999.90.131Contact Map0.657
2z1cA30.914699.90.136Contact Map0.683
3m9bA120.951233.90.887Contact Map0.32
2pb9A20.975629.30.89Contact Map0.065
4in3A20.865918.90.9Contact Map0.674
2wfwA30.9512140.906Contact Map0.305
2rcnA10.926812.50.908Contact Map0.708
3slkA20.87880.916Contact Map0.001
2eqjA10.48786.50.919Contact Map0.534

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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