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HYPC - Hydrogenase isoenzymes formation protein HypC
UniProt: P0AAM3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10485
Length: 90 (82)
Sequences: 641
Seq/Len: 7.82

HYPC
Paralog alert: 0.49 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: HYBG HYPC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
9_I 42_P 2.78 1.00
61_E 65_R 2.692 1.00
7_G 21_V 2.403 1.00
66_D 69_D 2.26 1.00
18_K 25_Q 2.106 1.00
62_A 66_D 2.078 1.00
17_A 30_L 1.951 1.00
65_R 69_D 1.854 1.00
67_T 71_L 1.722 1.00
10_R 25_Q 1.62 1.00
46_Q 58_V 1.589 1.00
29_D 32_L 1.558 1.00
11_T 18_K 1.556 1.00
64_A 68_L 1.513 1.00
8_Q 20_D 1.426 0.99
63_E 66_D 1.381 0.99
52_V 55_A 1.358 0.99
28_V 55_A 1.354 0.99
20_D 23_G 1.334 0.99
49_L 60_N 1.326 0.98
24_I 52_V 1.307 0.98
7_G 50_V 1.295 0.98
8_Q 61_E 1.276 0.98
8_Q 47_W 1.264 0.98
33_V 58_V 1.229 0.97
29_D 54_F 1.225 0.97
26_R 71_L 1.188 0.96
49_L 59_I 1.187 0.96
22_C 72_Q 1.177 0.96
70_A 73_N 1.142 0.95
36_C 39_N 1.127 0.95
81_V 84_L 1.103 0.94
9_I 17_A 1.096 0.94
7_G 29_D 1.093 0.93
12_I 44_V 1.078 0.93
7_G 20_D 1.075 0.93
7_G 32_L 1.072 0.93
80_D 83_A 1.066 0.92
21_V 26_R 1.059 0.92
18_K 27_D 1.059 0.92
7_G 19_V 1.02 0.90
52_V 57_S 1.013 0.89
26_R 56_M 1.001 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ot2A111000.091Contact Map0.552
3d3rA20.877899.90.143Contact Map0.643
2z1cA30.833399.90.144Contact Map0.66
4in3A20.788930.20.893Contact Map0.632
3m9bA120.855621.30.9Contact Map0.405
2rcnA10.933318.20.903Contact Map0.709
2pb9A20.988912.30.911Contact Map0.085
2eqjA10.42228.20.918Contact Map0.571
2ztdA20.93335.80.923Contact Map0.559
4n6aA20.44445.60.924Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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