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FDNH - Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit
UniProt: P0AAJ3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11228
Length: 294 (290)
Sequences: 364
Seq/Len: 1.26
FDNH
Paralog alert: 0.65 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FDNH FDOH HYBA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
235_E 242_K 3.134 1.00
185_H 195_L 2.299 0.99
193_L 213_V 2.276 0.99
150_L 157_V 2.25 0.99
176_V 184_I 2.074 0.98
78_T 97_K 2.028 0.97
107_G 142_G 2.001 0.97
46_Q 69_P 1.93 0.96
6_Q 9_I 1.918 0.96
145_F 222_T 1.833 0.95
40_I 181_T 1.829 0.95
2_A 292_H 1.758 0.93
34_I 224_V 1.753 0.93
189_K 193_L 1.625 0.89
6_Q 27_K 1.589 0.87
19_P 22_Q 1.554 0.85
57_D 76_S 1.553 0.85
285_V 292_H 1.553 0.85
3_M 6_Q 1.519 0.84
30_V 188_T 1.506 0.83
2_A 290_E 1.479 0.81
10_K 292_H 1.409 0.77
193_L 215_N 1.398 0.76
20_P 25_D 1.397 0.76
23_V 26_Y 1.388 0.75
197_E 201_A 1.38 0.75
273_I 290_E 1.378 0.74
202_K 205_A 1.367 0.74
193_L 200_V 1.344 0.72
172_E 176_V 1.344 0.72
18_T 22_Q 1.334 0.71
9_I 122_A 1.332 0.71
164_V 168_S 1.332 0.71
57_D 60_G 1.321 0.70
211_A 228_L 1.302 0.68
197_E 215_N 1.299 0.68
38_T 185_H 1.298 0.68
88_N 153_E 1.298 0.68
38_T 182_G 1.296 0.68
40_I 44_A 1.289 0.67
288_D 292_H 1.286 0.67
193_L 197_E 1.285 0.67
167_V 186_F 1.284 0.67
155_N 200_V 1.274 0.66
2_A 291_D 1.261 0.65
189_K 225_M 1.255 0.64
6_Q 50_S 1.254 0.64
23_V 291_D 1.254 0.64
188_T 191_E 1.251 0.64
52_W 165_D 1.247 0.63
77_W 158_Y 1.236 0.62
32_K 224_V 1.232 0.62
21_S 26_Y 1.218 0.61
44_A 51_E 1.213 0.60
68_N 111_A 1.209 0.60
191_E 256_A 1.209 0.60
3_M 268_T 1.208 0.60
6_Q 122_A 1.201 0.59
267_A 271_G 1.198 0.59
285_V 290_E 1.191 0.58
3_M 18_T 1.188 0.58
119_I 228_L 1.187 0.58
83_S 238_H 1.186 0.58
200_V 290_E 1.182 0.57
34_I 184_I 1.182 0.57
78_T 99_G 1.181 0.57
129_Q 278_G 1.176 0.57
18_T 24_R 1.174 0.56
6_Q 129_Q 1.173 0.56
203_L 211_A 1.167 0.56
34_I 99_G 1.163 0.55
88_N 263_A 1.162 0.55
8_I 18_T 1.161 0.55
285_V 288_D 1.153 0.54
219_V 222_T 1.151 0.54
10_K 287_D 1.146 0.54
260_L 266_I 1.14 0.53
6_Q 25_D 1.135 0.53
15_N 269_F 1.132 0.52
14_T 18_T 1.132 0.52
285_V 289_E 1.131 0.52
287_D 292_H 1.13 0.52
26_Y 289_E 1.123 0.51
2_A 11_R 1.119 0.51
128_F 148_P 1.119 0.51
172_E 177_K 1.116 0.51
73_S 167_V 1.113 0.50
2_A 5_T 1.113 0.50
140_I 191_E 1.104 0.50
2_A 6_Q 1.093 0.49
71_D 149_R 1.089 0.48
18_T 23_V 1.089 0.48
22_Q 25_D 1.085 0.48
84_E 93_W 1.084 0.48
34_I 226_Y 1.083 0.48
4_E 129_Q 1.082 0.47
19_P 25_D 1.074 0.47
190_K 201_A 1.072 0.46
11_R 25_D 1.072 0.46
20_P 23_V 1.071 0.46
182_G 225_M 1.069 0.46
8_I 24_R 1.067 0.46
74_A 198_Q 1.06 0.45
36_V 92_E 1.058 0.45
10_K 284_E 1.055 0.45
22_Q 290_E 1.053 0.45
8_I 14_T 1.052 0.44
191_E 213_V 1.051 0.44
10_K 20_P 1.051 0.44
158_Y 222_T 1.051 0.44
117_A 132_N 1.048 0.44
23_V 292_H 1.048 0.44
118_I 215_N 1.047 0.44
80_M 95_I 1.042 0.44
9_I 25_D 1.042 0.44
6_Q 130_S 1.041 0.43
283_K 286_D 1.041 0.43
2_A 25_D 1.041 0.43
46_Q 64_G 1.04 0.43
73_S 257_L 1.037 0.43
31_A 225_M 1.036 0.43
9_I 15_N 1.036 0.43
106_P 148_P 1.034 0.43
52_W 174_A 1.034 0.43
20_P 24_R 1.033 0.43
208_Y 286_D 1.033 0.43
52_W 166_R 1.031 0.42
47_V 178_T 1.029 0.42
72_L 93_W 1.029 0.42
117_A 142_G 1.029 0.42
121_Y 127_D 1.028 0.42
43_K 51_E 1.026 0.42
15_N 50_S 1.026 0.42
5_T 290_E 1.018 0.41
3_M 292_H 1.017 0.41
15_N 272_L 1.016 0.41
26_Y 291_D 1.016 0.41
67_D 180_P 1.012 0.41
11_R 26_Y 1.012 0.41
26_Y 292_H 1.011 0.41
262_A 266_I 1.008 0.40
3_M 27_K 1.007 0.40
34_I 134_I 1.005 0.40
268_T 272_L 1.004 0.40
9_I 27_K 1.003 0.40
6_Q 257_L 1.002 0.40
83_S 147_I 1 0.39
10_K 290_E 1 0.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1kqfB111000.403Contact Map0.421
1h0hB20.70751000.582Contact Map0.519
2ivfB10.9151000.655Contact Map0.523
1ti6B60.83671000.673Contact Map0.574
2vpzB20.65651000.688Contact Map0.562
1q16B10.8811000.754Contact Map0.56
3mm5B20.850399.80.831Contact Map0.205
2fgoA10.255199.40.875Contact Map0.329
1rgvA10.261999.40.876Contact Map0.324
3eunA10.268799.30.879Contact Map0.363
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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