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OPENSEQ.org
FTSH - ATP-dependent zinc metalloprotease FtsH
UniProt: P0AAI3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11506
Length: 644 (602)
Sequences: 2372
Seq/Len: 3.94
FTSH
Paralog alert: 0.16 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
562_Q 566_D 4.99 1.00
568_M 572_H 4.957 1.00
551_A 555_R 3.844 1.00
328_E 347_A 3.705 1.00
540_E 543_R 3.636 1.00
169_E 177_F 3.427 1.00
466_I 556_N 3.345 1.00
338_V 380_V 3.221 1.00
479_I 568_M 3.188 1.00
424_L 563_L 3.106 1.00
328_E 332_K 3.085 1.00
365_V 385_F 3.052 1.00
512_K 544_I 3.024 1.00
321_L 357_S 3.017 1.00
335_M 346_A 3.015 1.00
238_E 242_K 2.969 1.00
335_M 365_V 2.928 1.00
58_V 66_Y 2.921 1.00
477_E 561_R 2.914 1.00
377_K 384_E 2.914 1.00
478_I 564_L 2.901 1.00
40_E 45_Q 2.828 1.00
467_S 556_N 2.76 1.00
567_N 570_I 2.759 1.00
512_K 548_E 2.653 1.00
504_V 552_L 2.651 1.00
460_Q 484_H 2.645 1.00
581_Y 588_Q 2.64 1.00
466_I 500_A 2.626 1.00
427_E 464_S 2.607 1.00
76_K 79_D 2.598 1.00
377_K 381_S 2.537 1.00
469_L 495_V 2.535 1.00
572_H 576_D 2.504 1.00
421_I 467_S 2.462 1.00
331_L 361_L 2.45 1.00
422_G 448_F 2.428 1.00
512_K 547_Q 2.421 1.00
479_I 571_L 2.42 1.00
466_I 552_L 2.382 1.00
424_L 567_N 2.347 1.00
558_N 562_Q 2.339 1.00
179_K 378_R 2.321 1.00
33_D 36_T 2.306 1.00
115_V 119_F 2.297 1.00
37_F 41_V 2.283 1.00
487_T 507_W 2.224 1.00
491_N 494_K 2.223 1.00
561_R 565_T 2.213 1.00
375_G 387_K 2.21 1.00
510_S 548_E 2.176 1.00
381_S 384_E 2.164 1.00
411_T 456_S 2.147 1.00
474_L 561_R 2.143 1.00
496_A 553_I 2.133 1.00
422_G 468_T 2.131 1.00
477_E 557_Y 2.113 1.00
463_E 556_N 2.083 1.00
467_S 560_A 2.076 1.00
183_K 362_A 2.048 1.00
416_A 574_M 2.046 1.00
41_V 46_V 2.043 1.00
44_D 84_K 2.031 1.00
37_F 49_A 2.03 1.00
479_I 572_H 2.025 1.00
491_N 495_V 2.015 1.00
342_P 379_V 2.003 1.00
409_E 576_D 2 1.00
448_F 468_T 1.996 1.00
502_N 506_Q 1.989 1.00
462_L 499_L 1.973 1.00
406_A 409_E 1.933 1.00
478_I 565_T 1.918 1.00
502_N 507_W 1.915 1.00
463_E 555_R 1.894 1.00
454_A 461_K 1.894 1.00
550_K 554_E 1.879 1.00
462_L 487_T 1.856 1.00
557_Y 561_R 1.844 1.00
423_R 590_D 1.84 1.00
42_N 80_N 1.824 1.00
164_V 205_I 1.824 1.00
435_T 583_T 1.81 1.00
410_S 486_S 1.802 0.99
408_K 579_M 1.791 0.99
338_V 365_V 1.772 0.99
425_V 464_S 1.756 0.99
372_A 384_E 1.747 0.99
109_M 113_I 1.743 0.99
554_E 558_N 1.73 0.99
576_D 580_K 1.718 0.99
410_S 480_Y 1.696 0.99
175_S 179_K 1.686 0.99
341_A 379_V 1.671 0.99
325_R 328_E 1.669 0.99
335_M 385_F 1.657 0.99
48_E 87_K 1.652 0.99
577_A 581_Y 1.63 0.99
113_I 117_I 1.608 0.99
518_Y 545_I 1.603 0.99
158_D 326_G 1.576 0.98
329_Q 332_K 1.549 0.98
431_V 446_T 1.548 0.98
585_D 588_Q 1.544 0.98
595_R 598_V 1.543 0.98
214_F 243_A 1.543 0.98
560_A 563_L 1.541 0.98
577_A 584_I 1.528 0.98
459_R 463_E 1.513 0.98
458_S 486_S 1.513 0.98
565_T 568_M 1.512 0.98
469_L 496_A 1.506 0.98
107_F 110_L 1.498 0.97
375_G 384_E 1.498 0.97
246_C 291_I 1.484 0.97
46_V 60_K 1.481 0.97
434_V 446_T 1.473 0.97
543_R 547_Q 1.466 0.97
420_I 571_L 1.456 0.97
463_E 559_R 1.448 0.97
467_S 559_R 1.436 0.96
478_I 561_R 1.435 0.96
498_N 502_N 1.433 0.96
341_A 381_S 1.431 0.96
98_L 102_I 1.428 0.96
469_L 491_N 1.424 0.96
203_K 287_G 1.422 0.96
264_L 527_L 1.421 0.96
513_L 545_I 1.416 0.96
78_L 88_V 1.404 0.96
465_Q 495_V 1.401 0.96
573_A 595_R 1.399 0.96
428_H 448_F 1.395 0.96
58_V 68_T 1.389 0.96
246_C 290_G 1.387 0.95
413_Y 572_H 1.377 0.95
419_A 584_I 1.362 0.95
564_L 571_L 1.348 0.94
412_A 579_M 1.34 0.94
474_L 557_Y 1.337 0.94
79_D 83_T 1.334 0.94
473_R 489_A 1.329 0.94
32_V 58_V 1.327 0.94
109_M 112_L 1.325 0.94
480_Y 486_S 1.324 0.94
513_L 518_Y 1.323 0.94
257_G 307_L 1.322 0.94
548_E 551_A 1.322 0.94
464_S 559_R 1.321 0.94
469_L 499_L 1.315 0.93
176_R 376_N 1.312 0.93
559_R 562_Q 1.304 0.93
39_Q 43_N 1.304 0.93
478_I 568_M 1.302 0.93
405_E 409_E 1.3 0.93
443_L 456_S 1.292 0.93
56_I 68_T 1.29 0.93
409_E 480_Y 1.289 0.93
493_I 517_L 1.281 0.92
262_A 525_V 1.275 0.92
391_K 394_M 1.273 0.92
352_G 391_K 1.27 0.92
36_T 39_Q 1.269 0.92
110_L 114_G 1.269 0.92
111_L 114_G 1.264 0.92
77_L 81_L 1.263 0.92
537_M 542_A 1.257 0.91
421_I 471_G 1.25 0.91
457_A 461_K 1.249 0.91
525_V 529_R 1.245 0.91
516_L 553_I 1.244 0.91
416_A 575_K 1.244 0.91
540_E 544_I 1.24 0.91
569_D 573_A 1.238 0.90
552_L 556_N 1.237 0.90
428_H 464_S 1.233 0.90
50_R 91_E 1.233 0.90
347_A 351_R 1.232 0.90
500_A 552_L 1.228 0.90
526_F 529_R 1.227 0.90
390_D 433_K 1.225 0.90
34_Y 74_D 1.22 0.90
69_Y 92_P 1.212 0.89
239_Q 242_K 1.211 0.89
106_W 109_M 1.208 0.89
383_V 387_K 1.206 0.89
406_A 452_G 1.206 0.89
60_K 66_Y 1.202 0.89
137_S 235_D 1.2 0.89
241_K 288_N 1.197 0.88
79_D 82_L 1.19 0.88
188_V 292_I 1.188 0.88
167_L 188_V 1.182 0.88
371_F 384_E 1.176 0.87
389_K 394_M 1.174 0.87
428_H 468_T 1.174 0.87
544_I 547_Q 1.173 0.87
570_I 573_A 1.169 0.87
114_G 118_F 1.168 0.87
338_V 385_F 1.168 0.87
107_F 114_G 1.167 0.87
241_K 286_E 1.166 0.87
48_E 59_T 1.166 0.87
570_I 593_M 1.157 0.86
432_H 449_L 1.155 0.86
424_L 570_I 1.153 0.86
461_K 465_Q 1.151 0.86
184_I 292_I 1.149 0.86
525_V 530_S 1.145 0.85
111_L 115_V 1.143 0.85
82_L 88_V 1.14 0.85
562_Q 565_T 1.135 0.85
442_A 445_V 1.133 0.84
131_A 134_F 1.13 0.84
193_P 320_G 1.129 0.84
255_A 280_V 1.125 0.84
352_G 389_K 1.123 0.84
36_T 40_E 1.121 0.84
413_Y 576_D 1.12 0.84
180_L 373_A 1.114 0.83
409_E 413_Y 1.108 0.83
512_K 551_A 1.107 0.83
394_M 401_M 1.107 0.83
535_K 539_D 1.105 0.82
349_I 361_L 1.102 0.82
325_R 329_Q 1.102 0.82
505_T 545_I 1.097 0.82
577_A 591_D 1.094 0.81
32_V 40_E 1.092 0.81
425_V 428_H 1.09 0.81
44_D 85_N 1.085 0.81
405_E 408_K 1.081 0.80
429_D 465_Q 1.08 0.80
463_E 467_S 1.08 0.80
558_N 561_R 1.077 0.80
37_F 68_T 1.075 0.80
188_V 317_V 1.074 0.80
158_D 329_Q 1.07 0.79
109_M 115_V 1.07 0.79
504_V 549_V 1.069 0.79
558_N 565_T 1.061 0.79
448_F 469_L 1.06 0.79
390_D 445_V 1.06 0.79
323_D 326_G 1.059 0.79
74_D 77_L 1.058 0.78
214_F 239_Q 1.057 0.78
391_K 411_T 1.055 0.78
30_R 36_T 1.054 0.78
205_I 294_I 1.054 0.78
60_K 64_N 1.053 0.78
500_A 504_V 1.05 0.78
510_S 551_A 1.049 0.78
588_Q 591_D 1.048 0.77
574_M 592_L 1.048 0.77
340_L 344_I 1.047 0.77
421_I 563_L 1.046 0.77
32_V 66_Y 1.045 0.77
459_R 511_E 1.043 0.77
554_E 557_Y 1.043 0.77
258_R 261_G 1.04 0.77
262_A 529_R 1.04 0.77
456_S 486_S 1.037 0.76
495_V 498_N 1.035 0.76
71_P 90_G 1.029 0.76
34_Y 37_F 1.023 0.75
15_L 19_F 1.021 0.75
49_A 81_L 1.02 0.75
48_E 89_V 1.011 0.74
259_Q 529_R 1.009 0.74
487_T 491_N 1.005 0.73
494_K 498_N 1.003 0.73
403_M 408_K 1.002 0.73
104_I 108_P 1.001 0.73
414_H 418_H 1.001 0.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ce7A60.7361000.471Contact Map0.785
2dhrA60.77481000.5Contact Map0.641
4b4tJ10.6041000.74Contact Map0.375
2di4A20.36961000.742Contact Map0.764
4b4tI10.60871000.745Contact Map0.44
2x8aA10.39911000.757Contact Map0.567
4b4tK10.62111000.758Contact Map0.473
4b4tL10.62271000.765Contact Map0.412
4b4tM10.6041000.768Contact Map0.444
4b4tH10.58851000.77Contact Map0.472
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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