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OPENSEQ.org
UBID - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
UniProt: P0AAB4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11396
Length: 497 (486)
Sequences: 917
Seq/Len: 1.89
UBID
Paralog alert: 0.27 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
128_A 256_V 4.354 1.00
28_P 56_K 3.967 1.00
206_W 215_F 3.634 1.00
26_T 53_E 3.52 1.00
218_S 258_C 3.511 1.00
24_R 53_E 3.497 1.00
21_E 71_K 3.267 1.00
141_D 144_R 3.194 1.00
17_E 24_R 3.157 1.00
156_A 288_Y 3.124 1.00
276_Y 307_T 3.106 1.00
30_D 56_K 3.058 1.00
131_Q 259_I 3 1.00
371_K 403_D 2.972 1.00
421_M 453_L 2.923 1.00
284_P 300_S 2.889 1.00
32_H 149_T 2.828 1.00
133_K 313_E 2.792 1.00
39_A 64_C 2.765 1.00
143_N 183_L 2.664 1.00
284_P 298_V 2.653 1.00
224_D 249_R 2.622 1.00
214_R 278_E 2.452 1.00
218_S 261_N 2.443 1.00
260_S 308_H 2.433 1.00
35_I 62_V 2.396 1.00
406_N 409_D 2.379 1.00
133_K 311_Q 2.378 1.00
168_G 205_E 2.351 1.00
149_T 157_P 2.331 1.00
382_M 452_G 2.185 0.99
170_H 205_E 2.143 0.99
484_I 487_E 2.129 0.99
141_D 186_K 2.124 0.99
60_M 271_I 2.108 0.99
369_T 407_A 2.091 0.99
209_A 282_T 2.08 0.99
13_L 63_L 2.063 0.99
257_K 262_D 2.051 0.99
19_Q 71_K 2.047 0.99
409_D 412_D 1.988 0.99
189_L 306_V 1.986 0.99
424_A 431_E 1.984 0.99
132_Q 313_E 1.972 0.99
188_K 281_E 1.965 0.99
368_V 385_V 1.961 0.99
190_I 283_A 1.916 0.98
185_G 188_K 1.916 0.98
123_K 254_E 1.911 0.98
116_Q 119_N 1.863 0.98
17_E 53_E 1.862 0.98
22_L 51_L 1.856 0.98
475_P 479_A 1.839 0.98
427_T 451_M 1.805 0.97
27_L 487_E 1.8 0.97
271_I 311_Q 1.785 0.97
479_A 483_A 1.772 0.97
129_P 132_Q 1.769 0.97
424_A 449_S 1.751 0.97
257_K 264_E 1.735 0.96
214_R 279_Q 1.732 0.96
165_V 220_A 1.718 0.96
214_R 276_Y 1.685 0.95
60_M 315_A 1.684 0.95
8_D 268_S 1.679 0.95
42_T 50_L 1.655 0.95
258_C 265_V 1.65 0.95
484_I 488_L 1.64 0.94
134_I 259_I 1.613 0.94
383_M 430_V 1.6 0.93
130_C 310_T 1.594 0.93
51_L 63_L 1.573 0.93
421_M 427_T 1.564 0.92
90_K 345_Q 1.559 0.92
135_V 311_Q 1.557 0.92
324_R 412_D 1.552 0.92
159_I 183_L 1.549 0.92
273_L 306_V 1.538 0.92
104_F 108_F 1.528 0.91
369_T 401_C 1.524 0.91
188_K 283_A 1.519 0.91
42_T 490_I 1.516 0.91
473_K 478_V 1.509 0.91
110_K 114_F 1.502 0.90
175_N 241_E 1.499 0.90
19_Q 75_M 1.484 0.90
125_L 256_V 1.483 0.90
399_I 417_I 1.48 0.89
219_V 304_F 1.461 0.89
10_R 316_I 1.457 0.88
154_D 288_Y 1.456 0.88
481_I 485_W 1.442 0.88
21_E 72_R 1.436 0.87
59_S 144_R 1.432 0.87
137_G 140_V 1.431 0.87
258_C 261_N 1.427 0.87
254_E 268_S 1.426 0.87
183_L 306_V 1.423 0.87
131_Q 134_I 1.413 0.86
164_T 288_Y 1.408 0.86
106_D 110_K 1.395 0.85
27_L 484_I 1.392 0.85
159_I 189_L 1.385 0.85
147_I 183_L 1.372 0.84
260_S 307_T 1.371 0.84
131_Q 310_T 1.367 0.84
385_V 398_V 1.365 0.84
283_A 303_V 1.359 0.83
210_H 213_E 1.356 0.83
124_R 264_E 1.354 0.83
174_Q 264_E 1.345 0.82
12_F 76_G 1.329 0.81
110_K 116_Q 1.327 0.81
112_P 116_Q 1.327 0.81
27_L 54_N 1.306 0.80
130_C 258_C 1.29 0.79
135_V 144_R 1.278 0.78
184_I 190_I 1.274 0.77
188_K 305_T 1.273 0.77
159_I 221_L 1.272 0.77
475_P 478_V 1.262 0.76
348_F 384_G 1.261 0.76
165_V 258_C 1.261 0.76
136_S 308_H 1.257 0.76
183_L 189_L 1.236 0.74
31_P 57_G 1.229 0.74
14_T 17_E 1.223 0.73
482_D 488_L 1.222 0.73
87_E 90_K 1.22 0.73
184_I 188_K 1.217 0.73
184_I 283_A 1.203 0.71
417_I 453_L 1.191 0.70
299_D 445_S 1.184 0.70
481_I 484_I 1.183 0.70
230_G 245_A 1.181 0.69
181_Q 189_L 1.179 0.69
218_S 265_V 1.177 0.69
480_H 484_I 1.175 0.69
142_L 306_V 1.17 0.68
306_V 309_I 1.169 0.68
423_P 427_T 1.161 0.68
28_P 54_N 1.158 0.67
128_A 132_Q 1.141 0.66
165_V 242_Y 1.133 0.65
63_L 66_L 1.124 0.64
220_A 223_A 1.115 0.63
79_Q 88_V 1.11 0.62
235_V 244_F 1.11 0.62
112_P 118_L 1.107 0.62
261_N 264_E 1.106 0.62
206_W 216_P 1.106 0.62
483_A 488_L 1.104 0.62
105_R 108_F 1.101 0.62
10_R 314_D 1.1 0.61
258_C 264_E 1.098 0.61
367_V 414_I 1.096 0.61
479_A 482_D 1.094 0.61
480_H 483_A 1.092 0.61
140_V 187_N 1.092 0.61
51_L 316_I 1.09 0.60
125_L 128_A 1.089 0.60
153_E 469_R 1.088 0.60
476_D 481_I 1.085 0.60
174_Q 240_S 1.084 0.60
155_A 182_Q 1.084 0.60
93_A 345_Q 1.078 0.59
26_T 54_N 1.078 0.59
352_V 369_T 1.075 0.59
140_V 273_L 1.073 0.59
366_A 395_T 1.072 0.58
107_L 122_T 1.072 0.58
164_T 181_Q 1.071 0.58
483_A 487_E 1.07 0.58
422_D 441_A 1.068 0.58
391_Q 394_Y 1.067 0.58
478_V 482_D 1.067 0.58
474_D 479_A 1.066 0.58
281_E 305_T 1.061 0.57
135_V 139_D 1.059 0.57
194_L 296_N 1.056 0.57
15_L 19_Q 1.053 0.56
127_G 256_V 1.05 0.56
262_D 310_T 1.05 0.56
143_N 186_K 1.049 0.56
155_A 288_Y 1.048 0.56
185_G 283_A 1.046 0.56
476_D 486_D 1.044 0.55
189_L 304_F 1.044 0.55
10_R 270_E 1.044 0.55
485_W 489_A 1.042 0.55
356_L 366_A 1.041 0.55
14_T 18_Q 1.04 0.55
337_N 360_G 1.04 0.55
276_Y 305_T 1.039 0.55
94_F 114_F 1.038 0.55
165_V 370_I 1.037 0.55
224_D 227_T 1.035 0.54
166_T 199_G 1.034 0.54
187_N 305_T 1.027 0.54
234_P 328_E 1.024 0.53
15_L 75_M 1.021 0.53
25_I 50_L 1.021 0.53
484_I 490_I 1.018 0.53
138_D 186_K 1.017 0.52
22_L 49_A 1.016 0.52
477_V 481_I 1.015 0.52
21_E 75_M 1.012 0.52
168_G 172_E 1.011 0.52
476_D 479_A 1.009 0.52
36_T 321_Y 1.007 0.51
105_R 113_Q 1.004 0.51
480_H 488_L 1.003 0.51
397_F 423_P 1.003 0.51
124_R 255_V 1 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2idbA311000.049Contact Map0.814
4ip2A30.94161000.122Contact Map0.783
4kunA20.148921.80.981Contact Map0
3m1rA60.1207110.983Contact Map0.16
1b35D10.09059.60.983Contact Map0
2cyyA10.23148.60.984Contact Map0.11
2e1cA10.23148.50.984Contact Map0.158
4hw0A30.14297.70.984Contact Map0.361
1xfkA10.11477.10.984Contact Map0.026
2p5vA80.24145.70.985Contact Map0.111
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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