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OPENSEQ.org
YEDA - Uncharacterized inner membrane transporter YedA
UniProt: P0AA70 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11141
Length: 306 (278)
Sequences: 14098
Seq/Len: 50.71
YEDA
Paralog alert: 0.85 [within 20: 0.25] - ratio of genomes with paralogs
Cluster includes: EAMA RHTA YDDG YEDA YHBE YICL YIJE YTFF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
89_A 155_I 3.26 1.00
128_G 279_A 2.561 1.00
232_Y 236_N 2.467 1.00
48_G 186_L 2.434 1.00
12_A 232_Y 2.43 1.00
85_M 157_I 2.253 1.00
88_V 154_L 2.253 1.00
21_G 252_V 2.237 1.00
98_I 152_A 2.194 1.00
257_G 263_E 2.147 1.00
26_V 217_Y 2.06 1.00
100_A 253_A 2.026 1.00
109_F 159_S 2.012 1.00
232_Y 235_R 2.009 1.00
113_F 167_V 2.007 1.00
41_G 193_M 1.979 1.00
153_I 157_I 1.963 1.00
45_L 189_G 1.862 1.00
28_R 263_E 1.858 1.00
48_G 189_G 1.854 1.00
119_I 170_S 1.85 1.00
13_L 233_L 1.823 1.00
27_I 87_T 1.81 1.00
18_I 252_V 1.803 1.00
209_L 213_L 1.784 1.00
219_A 224_I 1.782 1.00
21_G 256_L 1.776 1.00
110_T 243_T 1.774 1.00
46_A 219_A 1.761 1.00
115_R 121_T 1.76 1.00
111_L 129_I 1.746 1.00
85_M 154_L 1.708 1.00
52_L 182_A 1.677 1.00
114_S 117_F 1.673 1.00
67_P 175_P 1.672 1.00
99_A 155_I 1.67 1.00
105_T 109_F 1.63 1.00
64_P 67_P 1.619 1.00
114_S 119_I 1.615 1.00
266_S 269_E 1.575 1.00
122_R 125_E 1.538 1.00
281_V 285_L 1.534 1.00
238_S 241_L 1.523 1.00
41_G 189_G 1.518 1.00
22_S 217_Y 1.503 1.00
267_K 271_L 1.501 1.00
85_M 161_S 1.494 1.00
256_L 260_L 1.487 1.00
94_V 152_A 1.477 1.00
49_I 53_A 1.477 1.00
252_V 256_L 1.47 1.00
132_G 247_Y 1.454 1.00
113_F 164_F 1.452 1.00
190_V 194_I 1.451 1.00
34_W 211_G 1.44 1.00
19_I 221_F 1.434 1.00
130_A 134_A 1.433 1.00
208_S 211_G 1.42 1.00
65_L 69_L 1.403 0.99
94_V 98_I 1.403 0.99
72_A 187_A 1.389 0.99
81_V 161_S 1.388 0.99
96_S 257_G 1.379 0.99
109_F 160_I 1.368 0.99
270_W 274_G 1.367 0.99
75_G 187_A 1.366 0.99
138_M 275_V 1.358 0.99
16_L 233_L 1.349 0.99
94_V 151_G 1.328 0.99
123_K 127_V 1.323 0.99
69_L 73_L 1.323 0.99
53_A 56_L 1.322 0.99
210_S 213_L 1.32 0.99
274_G 278_F 1.31 0.99
39_M 218_L 1.306 0.99
109_F 163_A 1.306 0.99
30_G 39_M 1.301 0.99
126_W 130_A 1.286 0.99
48_G 182_A 1.282 0.99
265_L 270_W 1.281 0.99
128_G 283_V 1.274 0.99
73_L 168_Y 1.254 0.99
101_V 273_L 1.252 0.99
139_L 272_A 1.251 0.99
93_N 150_W 1.25 0.99
169_G 231_M 1.239 0.98
12_A 229_A 1.232 0.98
194_I 197_M 1.23 0.98
138_M 268_I 1.228 0.98
35_P 38_M 1.226 0.98
25_F 256_L 1.225 0.98
97_G 254_V 1.222 0.98
66_R 69_L 1.216 0.98
52_L 56_L 1.208 0.98
22_S 256_L 1.205 0.98
50_L 224_I 1.195 0.98
96_S 261_G 1.194 0.98
121_T 126_W 1.192 0.98
41_G 196_S 1.187 0.98
88_V 93_N 1.18 0.98
33_S 211_G 1.179 0.98
90_E 99_A 1.178 0.98
163_A 167_V 1.177 0.98
93_N 151_G 1.176 0.98
115_R 120_K 1.161 0.97
70_N 168_Y 1.16 0.97
119_I 125_E 1.157 0.97
128_G 282_L 1.153 0.97
102_V 159_S 1.149 0.97
258_T 265_L 1.147 0.97
209_L 212_F 1.142 0.97
26_V 214_A 1.14 0.97
221_F 225_I 1.137 0.97
110_T 239_P 1.136 0.97
110_T 166_S 1.133 0.97
41_G 45_L 1.132 0.97
159_S 163_A 1.132 0.97
11_G 15_A 1.131 0.97
77_L 164_F 1.131 0.97
95_P 98_I 1.128 0.97
50_L 220_L 1.124 0.97
191_V 194_I 1.117 0.96
40_A 192_L 1.116 0.96
213_L 217_Y 1.113 0.96
149_P 153_I 1.103 0.96
51_L 224_I 1.099 0.96
216_G 219_A 1.096 0.96
170_S 239_P 1.089 0.96
37_L 84_G 1.088 0.96
50_L 219_A 1.083 0.96
234_I 238_S 1.078 0.95
102_V 155_I 1.074 0.95
47_A 185_M 1.071 0.95
251_V 273_L 1.068 0.95
96_S 263_E 1.068 0.95
16_L 229_A 1.068 0.95
171_R 175_P 1.067 0.95
102_V 156_L 1.066 0.95
76_L 191_V 1.065 0.95
20_W 226_A 1.063 0.95
30_G 214_A 1.061 0.95
123_K 126_W 1.056 0.95
134_A 138_M 1.054 0.95
105_T 136_I 1.048 0.94
135_G 272_A 1.046 0.94
108_L 132_G 1.045 0.94
88_V 92_Q 1.045 0.94
19_I 229_A 1.042 0.94
234_I 242_A 1.041 0.94
101_V 137_I 1.038 0.94
29_I 214_A 1.038 0.94
212_F 216_G 1.035 0.94
162_W 166_S 1.034 0.94
60_H 177_G 1.032 0.94
53_A 57_L 1.031 0.94
86_V 90_E 1.028 0.94
237_V 242_A 1.022 0.93
113_F 160_I 1.02 0.93
113_F 163_A 1.016 0.93
93_N 154_L 1.01 0.93
248_V 252_V 1.01 0.93
170_S 238_S 1.009 0.93
113_F 116_L 1.008 0.93
16_L 20_W 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i68A20.3987990.789Contact Map0.013
3b5dA20.356298.30.833Contact Map0.053
3j01B10.22884.90.96Contact Map0.037
1u7gA10.76143.90.962Contact Map0.229
3wdoA10.73863.70.963Contact Map0.184
2xutA30.71243.30.964Contact Map0.165
2cfqA10.60133.20.964Contact Map0.381
2kluA10.17322.80.965Contact Map0.547
2z15A40.22222.70.965Contact Map0.646
4he8J20.54582.70.965Contact Map0.237
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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