May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
RHTA - Inner membrane transporter RhtA
UniProt: P0AA67 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12134
Length: 295 (275)
Sequences: 12817
Seq/Len: 46.61
RHTA
Paralog alert: 0.84 [within 20: 0.20] - ratio of genomes with paralogs
Cluster includes: EAMA RHTA YDDG YEDA YHBE YICL YIJE YTFF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
91_S 153_A 3.407 1.00
124_W 275_A 2.566 1.00
228_I 232_R 2.503 1.00
25_Q 248_L 2.443 1.00
52_T 184_L 2.416 1.00
16_I 228_I 2.326 1.00
99_I 150_C 2.31 1.00
253_G 259_E 2.233 1.00
87_L 155_G 2.21 1.00
30_L 213_A 2.196 1.00
101_V 249_A 2.139 1.00
90_L 152_L 2.121 1.00
50_L 215_A 2.112 1.00
228_I 231_T 2.081 1.00
110_A 157_G 2.08 1.00
32_K 259_E 2.075 1.00
49_A 187_A 2.049 1.00
151_A 155_G 2.043 1.00
52_T 187_A 1.987 1.00
45_A 191_V 1.983 1.00
114_F 165_L 1.967 1.00
17_L 229_A 1.955 1.00
215_A 220_A 1.931 1.00
67_A 70_Q 1.907 1.00
205_W 209_P 1.89 1.00
22_A 248_L 1.888 1.00
70_Q 173_E 1.854 1.00
31_A 89_Y 1.842 1.00
25_Q 252_S 1.835 1.00
111_V 239_G 1.808 1.00
87_L 152_L 1.769 1.00
100_A 153_A 1.74 1.00
112_A 125_V 1.709 1.00
106_T 110_A 1.658 1.00
252_S 256_F 1.622 1.00
26_G 213_A 1.599 1.00
95_V 150_C 1.595 1.00
56_I 180_A 1.58 1.00
118_R 121_D 1.554 1.00
262_T 265_Q 1.542 1.00
45_A 187_A 1.538 1.00
263_P 267_L 1.522 1.00
87_L 159_C 1.516 1.00
95_V 99_I 1.494 1.00
78_G 185_I 1.476 1.00
126_V 130_L 1.464 1.00
114_F 162_I 1.446 1.00
266_L 270_G 1.445 1.00
38_V 207_V 1.441 1.00
248_L 252_S 1.432 1.00
53_L 57_A 1.423 1.00
95_V 149_G 1.416 1.00
128_A 243_S 1.41 1.00
83_G 159_C 1.406 0.99
97_L 253_G 1.404 0.99
234_P 237_T 1.402 0.99
43_V 214_V 1.389 0.99
34_L 43_V 1.377 0.99
29_S 252_S 1.361 0.99
134_F 271_A 1.36 0.99
75_L 185_I 1.356 0.99
174_H 177_A 1.356 0.99
119_P 123_V 1.355 0.99
30_L 210_L 1.352 0.99
110_A 158_A 1.345 0.99
161_A 165_L 1.334 0.99
206_S 209_P 1.332 0.99
188_L 192_P 1.323 0.99
68_K 72_L 1.321 0.99
26_G 252_S 1.315 0.99
94_T 148_T 1.314 0.99
134_F 264_I 1.3 0.99
102_A 269_L 1.296 0.99
270_G 274_A 1.284 0.99
90_L 94_T 1.281 0.99
79_V 189_I 1.28 0.99
20_A 229_A 1.278 0.99
57_A 60_K 1.278 0.99
204_H 207_V 1.269 0.99
23_S 217_L 1.255 0.99
76_F 166_S 1.253 0.99
124_W 279_S 1.232 0.98
16_I 225_L 1.231 0.98
54_I 220_A 1.228 0.98
212_L 215_A 1.225 0.98
122_F 126_V 1.221 0.98
39_G 42_G 1.22 0.98
69_E 72_L 1.218 0.98
261_L 266_L 1.215 0.98
98_G 250_A 1.214 0.98
230_L 234_P 1.211 0.98
217_L 221_L 1.21 0.98
82_G 189_I 1.206 0.98
45_A 194_G 1.203 0.98
72_L 76_F 1.201 0.98
90_L 93_Q 1.2 0.98
37_L 207_V 1.194 0.98
92_I 100_A 1.187 0.98
54_I 216_I 1.179 0.98
247_A 269_L 1.176 0.98
45_A 49_A 1.169 0.97
167_G 227_M 1.168 0.97
168_Q 235_T 1.166 0.97
108_P 112_A 1.16 0.97
103_L 157_G 1.159 0.97
157_G 161_A 1.159 0.97
135_L 268_A 1.157 0.97
97_L 259_E 1.156 0.97
44_T 190_F 1.151 0.97
110_A 161_A 1.149 0.97
106_T 132_L 1.148 0.97
24_I 226_E 1.148 0.97
52_T 180_A 1.146 0.97
277_M 281_L 1.142 0.97
14_I 241_L 1.132 0.97
205_W 208_I 1.126 0.97
80_S 162_I 1.126 0.97
73_P 166_S 1.125 0.97
192_P 195_A 1.125 0.97
15_V 19_V 1.124 0.97
24_I 222_P 1.118 0.96
20_A 24_I 1.116 0.96
29_S 253_G 1.108 0.96
94_T 149_G 1.104 0.96
96_P 99_I 1.093 0.96
33_S 210_L 1.091 0.96
103_L 153_A 1.09 0.96
208_I 212_L 1.09 0.96
168_Q 234_P 1.079 0.95
29_S 256_F 1.078 0.95
51_G 183_S 1.073 0.95
160_W 164_I 1.072 0.95
37_L 204_H 1.061 0.95
148_T 151_A 1.06 0.95
103_L 154_L 1.058 0.95
131_G 268_A 1.058 0.95
119_P 122_F 1.056 0.95
120_V 278_G 1.055 0.95
41_P 86_Y 1.045 0.94
209_P 213_A 1.043 0.94
169_R 173_E 1.042 0.94
102_A 133_W 1.038 0.94
88_F 92_I 1.036 0.94
21_M 25_Q 1.036 0.94
68_K 71_R 1.033 0.94
55_L 220_A 1.031 0.94
94_T 152_L 1.03 0.94
80_S 159_C 1.03 0.94
131_G 272_I 1.029 0.94
56_I 60_K 1.026 0.94
254_M 261_L 1.022 0.93
54_I 215_A 1.021 0.93
124_W 278_G 1.017 0.93
109_L 128_A 1.012 0.93
21_M 248_L 1.008 0.93
91_S 100_A 1.007 0.93
111_V 164_I 1.005 0.93
213_A 217_L 1.004 0.93
97_L 257_L 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i68A20.3932990.772Contact Map0.013
3b5dA20.369598.30.818Contact Map0.058
2kluA10.15595.10.957Contact Map0.384
2h3oA10.25.10.957Contact Map0.041
3j01B10.21364.30.959Contact Map0.021
2rddB10.11533.20.961Contact Map0.233
4hg6A10.32230.962Contact Map0.252
2l2tA20.14922.60.963Contact Map0.278
2cfqA10.60682.40.963Contact Map0.385
4ldsA20.57632.30.964Contact Map0.275
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 2.7075 seconds.