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OPENSEQ.org
QMCA - Protein QmcA
UniProt: P0AA53 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13258
Length: 305 (291)
Sequences: 3104
Seq/Len: 10.67
QMCA
Paralog alert: 0.58 [within 20: 0.30] - ratio of genomes with paralogs
Cluster includes: HFLC QMCA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
33_R 53_D 6.434 1.00
37_Y 40_T 5.47 1.00
93_D 96_R 4.168 1.00
234_R 237_K 3.681 1.00
237_K 241_E 3.05 1.00
141_R 145_E 2.829 1.00
201_E 205_Q 2.709 1.00
230_E 234_R 2.689 1.00
23_V 29_W 2.609 1.00
194_Q 197_I 2.596 1.00
39_K 53_D 2.557 1.00
33_R 38_T 2.365 1.00
217_S 221_Q 2.335 1.00
215_R 219_F 2.219 1.00
134_S 138_R 2.217 1.00
203_E 210_K 2.152 1.00
258_K 261_E 2.152 1.00
6_P 10_F 2.056 1.00
38_T 53_D 1.987 1.00
265_Q 268_S 1.966 1.00
27_Y 58_K 1.911 1.00
24_P 27_Y 1.888 1.00
195_A 199_K 1.863 1.00
103_N 106_L 1.831 1.00
75_S 128_M 1.828 1.00
131_Q 134_S 1.814 1.00
280_E 283_S 1.794 1.00
212_E 216_Q 1.77 1.00
188_E 192_I 1.765 1.00
261_E 264_Q 1.752 1.00
92_I 153_K 1.739 1.00
90_Q 153_K 1.731 1.00
122_S 138_R 1.708 1.00
137_S 141_R 1.671 1.00
19_G 47_L 1.653 1.00
22_I 45_L 1.648 1.00
120_L 128_M 1.621 1.00
28_Q 61_M 1.616 1.00
174_A 181_T 1.585 1.00
29_W 55_I 1.579 1.00
76_K 124_E 1.563 1.00
234_R 238_M 1.539 1.00
214_E 221_Q 1.521 1.00
107_A 111_L 1.482 1.00
216_Q 220_L 1.475 1.00
83_I 120_L 1.465 1.00
166_A 170_S 1.455 1.00
15_I 19_G 1.44 1.00
241_E 245_S 1.433 1.00
21_K 41_L 1.429 1.00
199_K 203_E 1.426 1.00
34_F 52_M 1.417 1.00
124_E 127_E 1.414 1.00
28_Q 94_A 1.412 1.00
32_E 99_Y 1.399 0.99
204_K 208_I 1.371 0.99
208_I 212_E 1.357 0.99
201_E 204_K 1.355 0.99
190_E 194_Q 1.323 0.99
63_E 155_T 1.318 0.99
18_A 21_K 1.313 0.99
59_I 98_A 1.312 0.99
14_V 18_A 1.301 0.99
114_T 118_T 1.3 0.99
206_S 210_K 1.296 0.99
144_D 153_K 1.295 0.99
182_K 186_I 1.294 0.99
20_V 47_L 1.276 0.99
186_I 190_E 1.275 0.99
15_I 51_F 1.275 0.99
111_L 143_V 1.253 0.99
119_V 138_R 1.251 0.99
90_Q 155_T 1.247 0.99
179_E 182_K 1.241 0.98
176_M 180_R 1.237 0.98
170_S 174_A 1.234 0.98
174_A 177_K 1.234 0.98
31_V 53_D 1.231 0.98
209_L 212_E 1.228 0.98
85_A 116_I 1.228 0.98
117_R 121_G 1.214 0.98
67_D 84_D 1.214 0.98
183_R 186_I 1.211 0.98
210_K 214_E 1.197 0.98
127_E 131_Q 1.177 0.98
81_V 125_L 1.164 0.97
205_Q 208_I 1.163 0.97
181_T 185_Y 1.16 0.97
49_V 53_D 1.158 0.97
87_C 112_T 1.15 0.97
287_S 290_G 1.148 0.97
96_R 100_E 1.145 0.97
177_K 181_T 1.143 0.97
29_W 58_K 1.142 0.97
288_I 292_A 1.139 0.97
200_A 209_L 1.133 0.97
64_Q 105_E 1.132 0.97
226_E 230_E 1.12 0.96
225_R 228_S 1.113 0.96
189_A 198_L 1.109 0.96
205_Q 209_L 1.107 0.96
31_V 41_L 1.101 0.96
37_Y 95_P 1.099 0.96
5_I 11_V 1.093 0.96
213_G 217_S 1.093 0.96
107_A 110_N 1.088 0.96
194_Q 198_L 1.084 0.96
108_I 112_T 1.077 0.95
123_M 138_R 1.073 0.95
138_R 141_R 1.068 0.95
282_S 285_M 1.065 0.95
72_E 82_T 1.064 0.95
7_I 11_V 1.064 0.95
220_L 223_E 1.063 0.95
266_I 276_M 1.061 0.95
287_S 291_I 1.06 0.95
28_Q 40_T 1.052 0.95
104_L 107_A 1.052 0.95
269_S 272_S 1.05 0.94
221_Q 224_A 1.042 0.94
39_K 46_S 1.041 0.94
276_M 279_L 1.04 0.94
179_E 183_R 1.036 0.94
142_I 145_E 1.03 0.94
10_F 13_L 1.03 0.94
97_A 104_L 1.026 0.94
30_T 98_A 1.025 0.93
86_V 158_E 1.023 0.93
28_Q 42_Q 1.018 0.93
79_A 172_M 1.017 0.93
242_A 246_G 1.016 0.93
31_V 39_K 1.011 0.93
119_V 139_L 1.007 0.93
48_V 55_I 1.005 0.93
101_V 150_W 1.002 0.92
196_E 199_K 1.001 0.92
84_D 160_R 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bk6A30.61641000.576Contact Map0.731
4fvgA10.43611000.643Contact Map0.74
1winA10.43931000.654Contact Map0.495
2rpbA10.370599.90.708Contact Map0.586
2zuoA130.9705960.915Contact Map0.648
3v6iB20.304944.10.954Contact Map0.381
4efaG10.390233.30.957Contact Map0.389
2dm9A20.439310.50.966Contact Map0.68
4hw9A70.57387.30.968Contact Map0.239
3arcL20.07547.10.969Contact Map0.33
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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