May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YFDV - Uncharacterized transporter YfdV
UniProt: P0AA49 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14144
Length: 314 (307)
Sequences: 2465
Seq/Len: 8.03
YFDV
Paralog alert: 0.35 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
50_F 185_L 4.833 1.00
168_I 172_K 4.355 1.00
50_F 181_L 2.978 1.00
270_P 295_S 2.731 1.00
21_F 25_R 2.692 1.00
238_L 302_T 2.647 1.00
249_G 259_L 2.639 1.00
253_H 256_S 2.625 1.00
14_V 199_T 2.49 1.00
177_W 181_L 2.429 1.00
116_V 268_L 2.425 1.00
44_A 206_A 2.377 1.00
22_S 43_Y 2.082 1.00
185_L 190_V 2.011 1.00
201_N 205_K 1.99 1.00
215_A 272_F 1.988 1.00
39_L 213_F 1.973 1.00
47_A 203_I 1.906 1.00
39_L 206_A 1.888 1.00
113_G 268_L 1.878 1.00
96_E 284_Y 1.833 1.00
47_A 200_F 1.803 1.00
23_G 220_A 1.796 1.00
44_A 207_N 1.792 1.00
47_A 178_A 1.759 1.00
51_V 204_A 1.736 1.00
234_T 295_S 1.735 1.00
103_I 270_P 1.717 1.00
301_V 304_P 1.64 1.00
34_R 38_K 1.637 1.00
33_A 217_L 1.63 1.00
256_S 259_L 1.613 1.00
10_L 195_A 1.605 1.00
39_L 44_A 1.588 1.00
80_F 84_F 1.587 1.00
275_I 292_L 1.56 1.00
235_F 239_I 1.537 1.00
246_L 250_M 1.528 1.00
49_L 178_A 1.517 1.00
255_N 259_L 1.514 1.00
180_V 184_I 1.485 0.99
51_V 200_F 1.484 0.99
22_S 213_F 1.472 0.99
43_Y 213_F 1.45 0.99
107_P 237_K 1.446 0.99
24_R 220_A 1.444 0.99
23_G 217_L 1.441 0.99
102_L 106_S 1.437 0.99
51_V 201_N 1.428 0.99
282_N 285_T 1.416 0.99
120_I 307_I 1.415 0.99
118_D 123_D 1.414 0.99
17_L 21_F 1.41 0.99
165_S 168_I 1.386 0.99
121_Y 261_M 1.381 0.99
10_L 14_V 1.368 0.99
194_A 198_P 1.367 0.99
164_L 168_I 1.367 0.99
128_G 132_A 1.358 0.99
38_K 280_R 1.353 0.99
278_A 283_V 1.352 0.99
103_I 291_S 1.352 0.99
178_A 182_A 1.351 0.99
234_T 238_L 1.344 0.99
51_V 197_D 1.343 0.99
257_E 261_M 1.338 0.99
40_V 210_V 1.329 0.99
218_T 275_I 1.324 0.99
197_D 201_N 1.323 0.99
125_V 128_G 1.323 0.99
15_I 203_I 1.322 0.99
15_I 213_F 1.314 0.98
40_V 207_N 1.313 0.98
104_A 236_L 1.307 0.98
237_K 241_M 1.299 0.98
51_V 55_R 1.284 0.98
23_G 221_A 1.283 0.98
53_I 182_A 1.282 0.98
238_L 295_S 1.277 0.98
139_N 143_I 1.265 0.98
246_L 263_V 1.261 0.98
29_S 32_Q 1.255 0.98
54_T 182_A 1.254 0.98
230_I 294_V 1.254 0.98
299_F 304_P 1.24 0.97
184_I 188_V 1.239 0.97
239_I 305_L 1.235 0.97
18_L 199_T 1.225 0.97
40_V 44_A 1.224 0.97
214_A 275_I 1.202 0.97
198_P 201_N 1.192 0.97
8_D 11_P 1.189 0.97
245_L 266_G 1.186 0.96
101_A 105_G 1.184 0.96
29_S 35_A 1.181 0.96
31_D 35_A 1.179 0.96
185_L 192_I 1.178 0.96
206_A 209_G 1.173 0.96
108_T 115_A 1.164 0.96
114_F 135_S 1.163 0.96
184_I 195_A 1.162 0.96
38_K 42_N 1.16 0.96
259_L 263_V 1.156 0.96
249_G 254_L 1.152 0.96
185_L 191_K 1.149 0.96
117_L 121_Y 1.144 0.95
111_F 277_I 1.138 0.95
234_T 298_G 1.137 0.95
248_V 251_A 1.13 0.95
13_I 302_T 1.127 0.95
132_A 265_A 1.122 0.95
103_I 108_T 1.118 0.95
299_F 303_A 1.118 0.95
267_A 303_A 1.114 0.94
54_T 185_L 1.113 0.94
175_V 212_V 1.104 0.94
41_L 275_I 1.101 0.94
57_N 60_M 1.1 0.94
206_A 210_V 1.097 0.94
233_N 291_S 1.095 0.94
99_V 288_G 1.094 0.94
297_L 301_V 1.094 0.94
32_Q 35_A 1.09 0.94
256_S 260_Q 1.088 0.94
42_N 47_A 1.086 0.93
88_K 91_K 1.084 0.93
85_G 90_F 1.077 0.93
301_V 305_L 1.075 0.93
41_L 111_F 1.07 0.93
243_L 306_W 1.066 0.93
270_P 292_L 1.048 0.92
179_P 271_A 1.047 0.92
48_A 207_N 1.047 0.92
39_L 210_V 1.046 0.92
208_S 211_A 1.045 0.92
128_G 131_V 1.044 0.92
243_L 247_L 1.037 0.91
37_N 214_A 1.019 0.90
247_L 250_M 1.016 0.90
117_L 261_M 1.015 0.90
58_R 186_V 1.015 0.90
263_V 306_W 1.015 0.90
18_L 43_Y 1.013 0.90
120_I 215_A 1.012 0.90
80_F 83_W 1.012 0.90
299_F 302_T 1.006 0.89
111_F 276_I 1.005 0.89
181_L 239_I 1.005 0.89
173_E 177_W 1.003 0.89
23_G 30_E 1.002 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3zuxA10.493699.80.683Contact Map0.484
4bwzA10.528771.20.933Contact Map0.436
2gfpA20.94913.40.956Contact Map0.186
2cfqA10.952210.90.958Contact Map0.181
2a65A10.32890.959Contact Map0.267
3o7qA10.939550.964Contact Map0.168
4i0uA100.26754.40.965Contact Map0.288
4ev6A50.26753.10.967Contact Map0.309
1zcdA20.48411.80.971Contact Map0.32
3mktA20.89811.60.972Contact Map0.173
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 1.3273 seconds.