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LPTB - Lipopolysaccharide export system ATP-binding protein LptB
UniProt: P0A9V1 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11680
Length: 241 (235)
Sequences: 71608
Seq/Len: 304.71

LPTB
Paralog alert: 0.94 [within 20: 0.84] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
33_G 204_C 3.324 1.00
5_T 25_T 3.054 1.00
30_E 206_R 3.033 1.00
59_N 66_D 3.016 1.00
130_L 133_S 2.989 1.00
32_V 208_Y 2.9 1.00
7_K 59_N 2.885 1.00
8_N 21_D 2.853 1.00
17_R 20_E 2.785 1.00
5_T 61_I 2.665 1.00
79_G 157_K 2.633 1.00
123_E 128_E 2.603 1.00
20_E 214_H 2.531 1.00
27_N 30_E 2.389 1.00
12_A 17_R 2.358 1.00
206_R 218_H 2.304 1.00
6_A 9_L 2.267 1.00
10_A 21_D 2.258 1.00
219_G 223_E 2.256 1.00
10_A 17_R 2.234 1.00
95_V 138_L 2.222 1.00
63_D 157_K 2.215 1.00
117_R 155_N 2.189 1.00
10_A 57_A 2.105 1.00
11_K 48_M 2.082 1.00
220_T 223_E 1.999 1.00
119_N 131_R 1.987 1.00
7_K 61_I 1.978 1.00
122_M 131_R 1.907 1.00
96_Y 132_D 1.898 1.00
96_Y 131_R 1.855 1.00
28_S 157_K 1.756 1.00
124_E 182_H 1.752 1.00
208_Y 215_L 1.741 1.00
96_Y 119_N 1.736 1.00
30_E 205_E 1.735 1.00
155_N 188_L 1.716 1.00
8_N 23_S 1.708 1.00
13_Y 18_V 1.706 1.00
133_S 137_S 1.667 1.00
208_Y 218_H 1.634 1.00
11_K 56_D 1.623 1.00
182_H 186_S 1.614 1.00
120_E 124_E 1.583 1.00
117_R 120_E 1.58 1.00
12_A 56_D 1.535 1.00
124_E 186_S 1.522 1.00
110_S 113_Q 1.521 1.00
85_Q 140_G 1.521 1.00
61_I 66_D 1.487 1.00
184_R 205_E 1.484 1.00
96_Y 118_A 1.479 1.00
115_E 119_N 1.45 1.00
46_F 193_T 1.43 1.00
96_Y 100_M 1.409 1.00
24_L 208_Y 1.401 0.99
26_V 32_V 1.386 0.99
128_E 131_R 1.383 0.99
19_V 48_M 1.379 0.99
7_K 25_T 1.369 0.99
48_M 55_R 1.369 0.99
11_K 53_V 1.365 0.99
116_D 120_E 1.332 0.99
119_N 123_E 1.323 0.99
96_Y 115_E 1.313 0.99
63_D 79_G 1.308 0.99
32_V 218_H 1.307 0.99
10_A 20_E 1.307 0.99
6_A 49_V 1.299 0.99
94_S 97_D 1.298 0.99
194_D 200_T 1.293 0.99
3_T 63_D 1.281 0.99
161_L 180_I 1.277 0.99
6_A 24_L 1.261 0.99
95_V 146_V 1.248 0.99
119_N 128_E 1.241 0.98
9_L 55_R 1.237 0.98
100_M 114_R 1.236 0.98
99_L 153_A 1.22 0.98
117_R 121_L 1.22 0.98
7_K 23_S 1.214 0.98
130_L 142_E 1.212 0.98
181_E 184_R 1.191 0.98
98_N 150_R 1.191 0.98
27_N 206_R 1.18 0.98
46_F 160_L 1.176 0.98
47_Y 53_V 1.164 0.97
125_F 149_A 1.161 0.97
157_K 188_L 1.16 0.97
31_I 184_R 1.146 0.97
6_A 45_T 1.131 0.97
100_M 118_A 1.127 0.97
219_G 224_I 1.118 0.96
179_I 182_H 1.117 0.96
134_M 137_S 1.103 0.96
28_S 63_D 1.084 0.96
173_V 199_E 1.079 0.95
11_K 44_T 1.078 0.95
113_Q 117_R 1.073 0.95
50_V 82_Y 1.069 0.95
183_L 188_L 1.068 0.95
31_I 190_V 1.067 0.95
211_S 216_I 1.05 0.94
184_R 190_V 1.048 0.94
100_M 115_E 1.045 0.94
177_K 199_E 1.041 0.94
126_H 175_D 1.037 0.94
113_Q 116_D 1.036 0.94
45_T 210_V 1.032 0.94
181_E 202_A 1.029 0.94
66_D 69_L 1.029 0.94
175_D 178_R 1.028 0.94
121_L 149_A 1.028 0.94
32_V 206_R 1.024 0.93
34_L 45_T 1.02 0.93
49_V 191_L 1.019 0.93
12_A 18_V 1.011 0.93
121_L 153_A 1.007 0.93
182_H 185_D 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC40.9959100-0.04Contact Map0.871
2yyzA10.9834100-0.039Contact Map0.801
1v43A10.9834100-0.038Contact Map0.808
2it1A20.9834100-0.038Contact Map0.86
1g29120.9959100-0.037Contact Map0.888
1oxxK10.9959100-0.036Contact Map0.793
1z47A20.9834100-0.032Contact Map0.822
3rlfA20.9834100-0.032Contact Map0.836
3fvqA20.9959100-0.028Contact Map0.764
1g6hA10.9793100-0.009Contact Map0.817

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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