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OPENSEQ.org
YBIT - Uncharacterized ABC transporter ATP-binding protein YbiT
UniProt: P0A9U3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13325
Length: 530 (526)
Sequences: 14719
Seq/Len: 27.98
YBIT
Paralog alert: 0.94 [within 20: 0.28] - ratio of genomes with paralogs
Cluster includes: ALSA ARAG GSIA LSRA MGLA MODF RBSA UUP XYLG YBHF YBIT YEJF YHES YJJK YPHE YTFR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
28_N 221_H 4.945 1.00
324_G 337_N 4.798 1.00
6_N 19_N 4.689 1.00
323_E 375_T 4.393 1.00
321_E 341_L 4.384 1.00
18_E 229_E 4.309 1.00
346_E 504_R 4.051 1.00
362_L 491_V 4.04 1.00
322_V 325_L 3.986 1.00
5_S 57_N 3.893 1.00
30_Y 223_A 3.672 1.00
4_S 7_V 3.507 1.00
321_E 377_K 3.416 1.00
3_V 23_K 3.391 1.00
363_K 369_L 3.17 1.00
15_P 18_E 3.164 1.00
31_G 219_C 2.97 1.00
348_L 506_L 2.944 1.00
134_R 137_E 2.849 1.00
349_A 502_A 2.807 1.00
3_V 59_S 2.767 1.00
336_K 512_R 2.765 1.00
322_V 340_L 2.707 1.00
422_L 432_I 2.691 1.00
44_M 208_I 2.681 1.00
61_D 175_D 2.621 1.00
324_G 339_N 2.62 1.00
132_E 150_Y 2.596 1.00
216_N 238_D 2.59 1.00
8_T 19_N 2.552 1.00
383_R 458_N 2.494 1.00
327_K 364_T 2.49 1.00
492_S 498_V 2.459 1.00
6_N 21_S 2.386 1.00
98_E 115_K 2.367 1.00
318_N 321_E 2.358 1.00
364_T 371_P 2.347 1.00
127_D 130_S 2.332 1.00
398_D 437_K 2.328 1.00
323_E 377_K 2.325 1.00
151_G 155_E 2.301 1.00
10_Q 15_P 2.298 1.00
327_K 372_D 2.293 1.00
65_R 175_D 2.21 1.00
130_S 134_R 2.21 1.00
199_N 217_M 2.201 1.00
362_L 461_I 2.201 1.00
11_F 51_L 2.191 1.00
134_R 173_D 2.153 1.00
326_T 337_N 2.149 1.00
344_V 458_N 2.134 1.00
4_S 22_V 2.108 1.00
326_T 373_S 2.104 1.00
361_L 508_I 2.092 1.00
490_F 501_L 2.036 1.00
333_P 336_K 1.99 1.00
8_T 15_P 1.981 1.00
80_T 83_D 1.96 1.00
4_S 47_L 1.935 1.00
342_L 348_L 1.932 1.00
141_G 200_E 1.931 1.00
67_G 169_A 1.922 1.00
317_R 344_V 1.907 1.00
223_A 230_L 1.897 1.00
136_G 140_L 1.886 1.00
25_G 28_N 1.884 1.00
78_E 154_S 1.883 1.00
29_R 198_L 1.826 1.00
349_A 498_V 1.814 1.00
323_E 339_N 1.808 1.00
421_I 454_M 1.805 1.00
420_S 424_R 1.792 1.00
152_P 155_E 1.791 1.00
366_V 461_I 1.779 1.00
340_L 506_L 1.769 1.00
69_L 179_L 1.758 1.00
133_A 137_E 1.753 1.00
469_L 477_L 1.751 1.00
26_G 175_D 1.74 1.00
343_E 346_E 1.717 1.00
266_Q 270_S 1.716 1.00
436_A 447_M 1.707 1.00
5_S 59_S 1.706 1.00
402_F 433_K 1.685 1.00
318_N 343_E 1.685 1.00
24_F 176_I 1.668 1.00
9_M 46_I 1.667 1.00
8_T 55_L 1.661 1.00
422_L 429_Q 1.657 1.00
138_L 171_F 1.656 1.00
198_L 205_M 1.654 1.00
400_T 403_E 1.649 1.00
236_N 239_E 1.648 1.00
328_G 372_D 1.636 1.00
85_V 171_F 1.635 1.00
322_V 365_L 1.625 1.00
6_N 55_L 1.614 1.00
421_I 450_G 1.612 1.00
342_L 487_T 1.604 1.00
148_Q 151_G 1.599 1.00
130_S 133_A 1.597 1.00
261_Q 264_E 1.593 1.00
318_N 341_L 1.592 1.00
424_R 483_L 1.591 1.00
431_D 434_K 1.584 1.00
175_D 203_S 1.579 1.00
439_L 447_M 1.576 1.00
324_G 373_S 1.567 1.00
5_S 21_S 1.564 1.00
325_L 371_P 1.564 1.00
5_S 23_K 1.558 1.00
322_V 376_V 1.557 1.00
48_G 68_K 1.542 1.00
157_A 160_W 1.526 1.00
344_V 487_T 1.514 1.00
387_Y 462_M 1.514 1.00
24_F 30_Y 1.503 1.00
9_M 42_T 1.497 1.00
323_E 341_L 1.486 1.00
347_K 481_L 1.48 1.00
137_E 141_G 1.458 1.00
2_L 60_L 1.458 1.00
7_V 46_I 1.449 1.00
50_D 70_R 1.439 1.00
327_K 369_L 1.432 1.00
335_F 338_L 1.418 1.00
434_K 438_V 1.414 1.00
399_L 403_E 1.41 1.00
406_S 414_D 1.408 1.00
44_M 178_L 1.407 0.99
192_R 217_M 1.406 0.99
60_L 176_I 1.405 0.99
417_A 420_S 1.404 0.99
401_V 447_M 1.393 0.99
141_G 201_R 1.39 0.99
75_A 153_M 1.38 0.99
209_S 215_L 1.372 0.99
219_C 222_M 1.371 0.99
234_P 239_E 1.363 0.99
22_V 223_A 1.359 0.99
378_W 459_I 1.344 0.99
375_T 381_N 1.332 0.99
419_R 423_G 1.33 0.99
10_Q 55_L 1.325 0.99
325_L 364_T 1.324 0.99
419_R 432_I 1.322 0.99
348_L 489_I 1.315 0.99
435_P 438_V 1.3 0.99
346_E 503_T 1.296 0.99
396_E 399_L 1.296 0.99
82_L 135_A 1.282 0.99
402_F 432_I 1.275 0.99
69_L 169_A 1.274 0.99
462_M 481_L 1.274 0.99
11_F 42_T 1.27 0.99
142_V 167_A 1.27 0.99
44_M 68_K 1.266 0.99
499_S 521_E 1.261 0.99
17_F 20_I 1.26 0.99
45_K 50_D 1.258 0.99
46_I 58_V 1.255 0.99
318_N 344_V 1.254 0.99
342_L 459_I 1.253 0.99
384_I 459_I 1.239 0.98
1_M 204_T 1.238 0.98
76_F 87_M 1.231 0.98
328_G 333_P 1.229 0.98
156_V 164_V 1.228 0.98
82_L 132_E 1.227 0.98
416_Q 420_S 1.225 0.98
267_S 270_S 1.224 0.98
132_E 136_G 1.223 0.98
326_T 336_K 1.22 0.98
26_G 204_T 1.21 0.98
31_G 215_L 1.208 0.98
506_L 513_V 1.207 0.98
385_G 457_P 1.205 0.98
8_T 18_E 1.203 0.98
139_L 149_H 1.194 0.98
192_R 196_Q 1.189 0.98
95_V 119_L 1.189 0.98
481_L 488_L 1.189 0.98
219_C 237_Y 1.186 0.98
461_I 489_I 1.184 0.98
46_I 53_P 1.182 0.98
239_E 243_A 1.181 0.98
11_F 16_L 1.181 0.98
337_N 512_R 1.18 0.98
19_N 229_E 1.179 0.98
404_W 451_K 1.177 0.98
335_F 364_T 1.173 0.98
195_E 217_M 1.171 0.98
86_I 135_A 1.169 0.97
413_D 416_Q 1.167 0.97
358_K 464_E 1.164 0.97
399_L 407_Q 1.164 0.97
350_V 506_L 1.163 0.97
415_E 419_R 1.161 0.97
464_E 493_H 1.161 0.97
10_Q 54_T 1.156 0.97
161_K 390_D 1.155 0.97
41_S 45_K 1.147 0.97
28_N 220_T 1.144 0.97
395_F 436_A 1.142 0.97
67_G 174_P 1.139 0.97
255_N 259_K 1.137 0.97
319_A 487_T 1.133 0.97
77_E 161_K 1.133 0.97
221_H 232_V 1.13 0.97
140_L 145_P 1.127 0.97
4_S 58_V 1.119 0.96
136_G 149_H 1.114 0.96
519_N 522_D 1.113 0.96
231_R 247_A 1.11 0.96
153_M 164_V 1.11 0.96
269_V 286_A 1.109 0.96
246_Q 249_E 1.109 0.96
12_G 15_P 1.105 0.96
392_E 444_K 1.101 0.96
402_F 418_V 1.098 0.96
422_L 427_F 1.097 0.96
340_L 361_L 1.097 0.96
7_V 53_P 1.092 0.96
359_S 463_D 1.089 0.96
196_Q 200_E 1.085 0.96
317_R 343_E 1.085 0.96
169_A 177_L 1.084 0.96
2_L 176_I 1.076 0.95
60_L 66_I 1.071 0.95
364_T 376_V 1.07 0.95
9_M 51_L 1.066 0.95
137_E 140_L 1.062 0.95
90_K 94_E 1.061 0.95
30_Y 206_I 1.059 0.95
351_L 498_V 1.053 0.95
2_L 47_L 1.051 0.94
410_Q 413_D 1.051 0.94
123_Y 128_G 1.048 0.94
498_V 502_A 1.046 0.94
481_L 501_L 1.045 0.94
20_I 230_L 1.045 0.94
354_N 493_H 1.042 0.94
426_L 476_S 1.041 0.94
350_V 361_L 1.04 0.94
366_V 386_Y 1.036 0.94
252_L 256_A 1.031 0.94
78_E 152_P 1.027 0.94
402_F 415_E 1.026 0.94
147_E 151_G 1.024 0.93
385_G 452_L 1.023 0.93
193_W 196_Q 1.021 0.93
363_K 368_D 1.021 0.93
86_I 131_A 1.02 0.93
91_E 122_K 1.02 0.93
140_L 146_V 1.018 0.93
29_R 205_M 1.016 0.93
359_S 389_Q 1.014 0.93
318_N 377_K 1.011 0.93
196_Q 199_N 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4finA20.98871000.152Contact Map0.756
2iw3A20.83021000.268Contact Map0.739
3g5uA20.92831000.291Contact Map0.66
4f4cA10.92641000.301Contact Map0.741
1yqtA10.84151000.308Contact Map0.677
3bk7A10.87171000.316Contact Map0.647
3ozxA20.87171000.323Contact Map0.709
3j16B10.87921000.339Contact Map0.474
3ux8A10.84151000.367Contact Map0.614
2vf7A30.82641000.488Contact Map0.602
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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