May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
P5CR - Pyrroline-5-carboxylate reductase
UniProt: P0A9L8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10769
Length: 269 (268)
Sequences: 2409
Seq/Len: 8.99
P5CR
Paralog alert: 0.14 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
118_A 131_T 3.442 1.00
76_M 97_A 3.062 1.00
182_F 252_V 2.884 1.00
128_A 213_K 2.763 1.00
114_K 143_D 2.691 1.00
179_V 208_V 2.654 1.00
213_K 217_E 2.604 1.00
6_G 60_V 2.548 1.00
183_I 215_V 2.444 1.00
196_P 199_Q 2.35 1.00
180_F 211_S 2.341 1.00
186_M 256_M 2.208 1.00
123_P 129_G 2.189 1.00
10_C 34_V 2.176 1.00
220_E 228_M 2.152 1.00
178_Y 239_A 2.151 1.00
156_E 202_K 2.147 1.00
175_S 207_A 2.144 1.00
35_Y 57_A 2.069 1.00
246_K 251_A 2.053 1.00
130_M 156_E 2.053 1.00
242_V 246_K 2.044 1.00
187_A 201_Y 2.017 1.00
220_E 224_A 2.015 1.00
106_A 136_N 2.004 1.00
188_D 197_R 1.869 1.00
17_I 154_F 1.862 1.00
205_A 216_L 1.857 1.00
148_L 152_R 1.816 1.00
93_V 109_L 1.799 1.00
95_S 105_L 1.752 1.00
144_T 159_V 1.748 1.00
209_M 213_K 1.747 1.00
148_L 159_V 1.738 1.00
182_F 248_F 1.725 1.00
141_P 145_A 1.714 1.00
213_K 216_L 1.703 1.00
13_M 96_I 1.697 1.00
6_G 64_A 1.696 1.00
7_F 14_G 1.693 1.00
56_S 59_E 1.692 1.00
262_K 265_K 1.661 1.00
94_V 147_V 1.658 1.00
140_T 143_D 1.658 1.00
132_S 168_V 1.654 1.00
179_V 182_F 1.648 1.00
248_F 252_V 1.633 1.00
166_H 263_S 1.599 1.00
244_E 249_R 1.586 1.00
39_P 43_A 1.569 1.00
206_Q 209_M 1.545 1.00
191_V 197_R 1.543 1.00
230_C 237_I 1.53 1.00
160_I 165_I 1.522 1.00
14_G 18_L 1.521 1.00
237_I 241_R 1.503 1.00
224_A 228_M 1.495 1.00
152_R 157_A 1.487 1.00
190_A 195_M 1.482 1.00
36_T 41_K 1.471 1.00
158_E 202_K 1.47 1.00
15_K 41_K 1.466 1.00
188_D 249_R 1.461 1.00
174_S 235_T 1.46 1.00
248_F 251_A 1.449 1.00
192_L 257_T 1.426 0.99
66_I 92_L 1.405 0.99
128_A 209_M 1.402 0.99
245_E 254_E 1.393 0.99
184_E 226_K 1.375 0.99
37_P 75_I 1.368 0.99
97_A 100_V 1.356 0.99
130_M 206_Q 1.341 0.99
135_P 144_T 1.331 0.99
247_G 251_A 1.329 0.99
17_I 21_L 1.328 0.99
183_I 208_V 1.327 0.99
246_K 254_E 1.318 0.99
88_N 91_S 1.314 0.99
102_L 105_L 1.298 0.99
184_E 223_G 1.293 0.99
260_M 264_E 1.291 0.99
66_I 146_D 1.29 0.99
221_H 224_A 1.286 0.99
230_C 240_V 1.283 0.99
243_L 255_A 1.276 0.98
34_V 51_I 1.268 0.98
242_V 245_E 1.263 0.98
7_F 68_F 1.251 0.98
224_A 227_D 1.242 0.98
33_W 52_N 1.24 0.98
60_V 64_A 1.233 0.98
18_L 34_V 1.225 0.98
102_L 134_T 1.218 0.98
70_A 96_I 1.211 0.98
133_V 159_V 1.21 0.98
106_A 137_A 1.204 0.97
227_D 237_I 1.197 0.97
69_A 76_M 1.194 0.97
106_A 138_L 1.191 0.97
256_M 259_C 1.191 0.97
59_E 63_I 1.19 0.97
7_F 18_L 1.177 0.97
71_V 97_A 1.173 0.97
183_I 204_A 1.17 0.97
223_G 226_K 1.168 0.97
92_L 143_D 1.155 0.97
101_T 104_Q 1.151 0.96
170_G 256_M 1.151 0.96
43_A 47_D 1.15 0.96
193_G 257_T 1.15 0.96
243_L 252_V 1.139 0.96
192_L 253_I 1.137 0.96
250_A 254_E 1.137 0.96
226_K 230_C 1.133 0.96
161_A 164_M 1.129 0.96
116_I 147_V 1.126 0.96
77_I 108_A 1.124 0.96
41_K 44_A 1.119 0.96
128_A 206_Q 1.113 0.95
76_M 80_L 1.111 0.95
15_K 49_F 1.1 0.95
133_V 151_F 1.1 0.95
76_M 100_V 1.093 0.95
103_D 107_R 1.091 0.95
124_A 129_G 1.088 0.95
77_I 104_Q 1.087 0.95
180_F 214_M 1.084 0.95
102_L 115_I 1.071 0.94
241_R 245_E 1.065 0.94
33_W 54_A 1.064 0.94
133_V 157_A 1.06 0.94
75_I 79_V 1.06 0.94
42_V 55_E 1.058 0.94
80_L 109_L 1.051 0.93
239_A 255_A 1.048 0.93
130_M 158_E 1.044 0.93
169_V 175_S 1.029 0.92
257_T 261_E 1.027 0.92
195_M 203_F 1.023 0.92
28_L 31_Q 1.009 0.91
168_V 172_S 1.008 0.91
6_G 35_Y 1.006 0.91
168_V 203_F 1.003 0.91
172_S 203_F 1.003 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2izzA50.99631000.347Contact Map0.852
2rcyA50.96651000.353Contact Map0.831
1yqgA10.96651000.373Contact Map0.631
2ahrA50.95911000.375Contact Map0.836
3triA20.99631000.388Contact Map0.857
3gt0A10.91821000.427Contact Map0.685
3fr7A20.94051000.514Contact Map0.423
4kqwA20.96281000.529Contact Map0.332
2i76A20.92571000.55Contact Map0.447
4e21A20.93311000.572Contact Map0.411
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.2476 seconds.