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OPENSEQ.org
PHOL - PhoH-like protein
UniProt: P0A9K3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13656
Length: 346 (317)
Sequences: 1268
Seq/Len: 4.00
PHOL
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
131_N 298_S 3.57 1.00
150_Y 205_E 3.447 1.00
304_S 318_N 2.861 1.00
259_I 265_A 2.795 1.00
38_I 49_L 2.676 1.00
296_E 315_R 2.508 1.00
288_I 299_F 2.457 1.00
170_L 199_L 2.363 1.00
136_D 264_K 2.348 1.00
238_F 266_V 2.344 1.00
141_V 288_I 2.294 1.00
36_L 59_A 2.274 1.00
135_H 296_E 2.23 1.00
249_I 286_H 2.208 1.00
288_I 301_F 2.191 1.00
158_D 162_R 2.188 1.00
166_R 236_D 2.148 1.00
126_A 130_A 2.123 1.00
66_L 88_A 2.083 1.00
188_L 228_Y 2.071 1.00
137_I 312_V 1.963 1.00
289_E 323_W 1.935 1.00
135_H 298_S 1.875 1.00
171_T 314_A 1.863 1.00
292_A 301_F 1.856 1.00
294_V 315_R 1.846 1.00
27_D 82_P 1.834 1.00
38_I 59_A 1.829 1.00
60_A 64_R 1.825 1.00
21_L 70_T 1.819 1.00
311_P 315_R 1.816 1.00
137_I 267_I 1.805 1.00
49_L 59_A 1.788 0.99
141_V 301_F 1.785 0.99
199_L 268_T 1.772 0.99
241_L 255_F 1.763 0.99
281_K 289_E 1.752 0.99
154_A 206_M 1.75 0.99
137_I 297_I 1.746 0.99
286_H 290_V 1.715 0.99
32_L 63_L 1.673 0.99
120_P 129_I 1.647 0.99
139_F 299_F 1.623 0.99
160_L 220_V 1.604 0.99
17_R 70_T 1.592 0.98
171_T 188_L 1.587 0.98
131_N 300_N 1.579 0.98
40_I 49_L 1.538 0.98
128_Y 140_G 1.527 0.98
132_I 155_A 1.519 0.98
51_G 56_V 1.512 0.98
140_G 302_F 1.499 0.98
124_N 302_F 1.488 0.97
66_L 85_I 1.485 0.97
236_D 262_N 1.467 0.97
49_L 60_A 1.464 0.97
35_R 89_I 1.461 0.97
141_V 299_F 1.46 0.97
271_V 288_I 1.45 0.97
274_I 285_R 1.417 0.96
32_L 62_I 1.395 0.96
9_T 46_H 1.388 0.96
49_L 56_V 1.383 0.96
239_I 265_A 1.377 0.95
215_L 220_V 1.356 0.95
239_I 263_S 1.356 0.95
53_P 57_T 1.354 0.95
32_L 89_I 1.346 0.95
249_I 317_V 1.337 0.94
119_K 228_Y 1.328 0.94
228_Y 304_S 1.325 0.94
57_T 60_A 1.322 0.94
153_V 212_V 1.318 0.94
81_E 84_Q 1.315 0.94
295_E 315_R 1.313 0.94
155_A 159_A 1.306 0.93
31_Q 86_H 1.303 0.93
204_F 212_V 1.295 0.93
302_F 324_E 1.291 0.93
22_C 42_R 1.287 0.93
107_K 133_L 1.283 0.93
146_T 307_V 1.272 0.92
17_R 71_A 1.27 0.92
271_V 285_R 1.257 0.92
136_D 296_E 1.256 0.92
133_L 155_A 1.256 0.92
36_L 89_I 1.256 0.92
208_G 212_V 1.255 0.91
54_I 267_I 1.241 0.91
174_A 196_L 1.237 0.91
127_Q 130_A 1.236 0.91
171_T 224_A 1.213 0.90
20_S 70_T 1.21 0.89
12_P 47_F 1.207 0.89
122_T 171_T 1.203 0.89
153_V 207_L 1.203 0.89
132_I 266_V 1.193 0.88
132_I 264_K 1.188 0.88
24_P 27_D 1.179 0.88
193_D 208_G 1.177 0.88
129_I 266_V 1.174 0.87
22_C 47_F 1.154 0.86
157_V 203_L 1.153 0.86
287_A 299_F 1.14 0.85
286_H 323_W 1.135 0.85
159_A 164_E 1.135 0.85
12_P 17_R 1.134 0.85
40_I 63_L 1.133 0.85
262_N 279_N 1.126 0.84
34_R 295_E 1.122 0.84
156_A 159_A 1.121 0.84
187_D 190_Q 1.111 0.83
160_L 190_Q 1.109 0.83
287_A 323_W 1.107 0.83
250_E 272_T 1.104 0.83
199_L 240_I 1.1 0.82
33_E 214_K 1.098 0.82
150_Y 202_A 1.092 0.82
23_G 26_D 1.088 0.81
12_P 18_L 1.086 0.81
134_D 292_A 1.086 0.81
36_L 55_C 1.08 0.81
115_R 302_F 1.079 0.81
197_R 222_E 1.063 0.79
253_K 324_E 1.062 0.79
128_Y 151_L 1.057 0.79
22_C 300_N 1.054 0.78
132_I 159_A 1.053 0.78
47_F 69_D 1.041 0.77
122_T 302_F 1.038 0.77
189_S 265_A 1.035 0.77
12_P 67_Y 1.033 0.76
121_R 261_F 1.032 0.76
294_V 297_I 1.03 0.76
195_Y 241_L 1.025 0.76
111_I 158_D 1.023 0.75
189_S 235_N 1.018 0.75
57_T 61_D 1.016 0.75
150_Y 199_L 1.013 0.74
83_E 87_L 1.012 0.74
39_E 50_T 1.011 0.74
159_A 165_I 1.01 0.74
138_T 298_S 1.002 0.73
18_L 22_C 1.001 0.73
215_L 304_S 1 0.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3b85A20.60121000.785Contact Map0.666
3upuA30.65999.50.899Contact Map0.542
4c2uA20.664799.30.911Contact Map0.474
3lfuA10.65999.20.912Contact Map0.447
3e1sA10.875799.10.918Contact Map0.593
1uaaA20.6329990.92Contact Map0.58
1w36D20.939398.90.922Contact Map0.532
4c2tA40.664798.80.925Contact Map0.486
2gk6A20.945198.60.93Contact Map0.4
1t6nA20.563698.60.931Contact Map0.4
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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