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OPENSEQ.org
GCVR - Glycine cleavage system transcriptional repressor
UniProt: P0A9I3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11149
Length: 190 (175)
Sequences: 391
Seq/Len: 2.23
GCVR
Paralog alert: 0.20 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
98_V 116_F 2.589 1.00
17_D 20_G 2.58 1.00
15_G 77_L 2.116 1.00
41_L 128_S 2.034 0.99
108_L 128_S 1.897 0.99
22_V 48_F 1.693 0.97
10_V 51_I 1.691 0.97
163_K 171_A 1.674 0.97
71_K 123_I 1.61 0.95
12_T 48_F 1.561 0.94
21_I 143_I 1.534 0.94
41_L 108_L 1.506 0.93
9_L 56_G 1.489 0.92
21_I 48_F 1.442 0.91
20_G 48_F 1.439 0.90
163_K 170_N 1.436 0.90
36_I 50_F 1.431 0.90
109_I 122_N 1.431 0.90
35_N 104_D 1.416 0.89
33_G 156_A 1.41 0.89
9_L 42_A 1.382 0.88
149_S 155_A 1.381 0.88
98_V 147_A 1.378 0.88
27_R 31_S 1.369 0.87
64_I 109_I 1.359 0.87
23_N 102_V 1.324 0.85
17_D 22_V 1.307 0.84
17_D 44_L 1.293 0.83
18_R 44_L 1.268 0.81
9_L 68_L 1.265 0.81
22_V 122_N 1.263 0.81
17_D 122_N 1.26 0.81
10_V 49_T 1.237 0.79
38_D 53_L 1.227 0.78
56_G 65_E 1.215 0.77
48_F 77_L 1.2 0.76
34_C 141_L 1.199 0.76
115_L 165_L 1.199 0.76
34_C 111_R 1.19 0.75
34_C 56_G 1.185 0.75
65_E 83_R 1.183 0.74
39_S 128_S 1.172 0.73
11_I 14_L 1.17 0.73
36_I 143_I 1.164 0.73
61_I 69_P 1.159 0.72
103_A 171_A 1.157 0.72
91_P 152_S 1.148 0.71
11_I 169_L 1.147 0.71
19_P 126_L 1.144 0.71
17_D 21_I 1.137 0.70
47_E 82_K 1.132 0.70
14_L 47_E 1.13 0.69
111_R 147_A 1.129 0.69
14_L 169_L 1.121 0.69
22_V 128_S 1.118 0.68
107_H 141_L 1.11 0.67
114_A 118_A 1.109 0.67
17_D 46_E 1.096 0.66
124_A 148_H 1.094 0.66
41_L 105_S 1.093 0.66
111_R 160_Q 1.091 0.66
79_I 125_E 1.085 0.65
123_I 126_L 1.078 0.64
137_R 170_N 1.077 0.64
67_T 105_S 1.07 0.63
70_L 117_D 1.068 0.63
7_H 77_L 1.057 0.62
17_D 48_F 1.056 0.62
48_F 51_I 1.054 0.62
13_A 84_T 1.046 0.61
57_S 140_Q 1.046 0.61
39_S 48_F 1.044 0.60
7_H 149_S 1.043 0.60
12_T 20_G 1.043 0.60
33_G 106_P 1.042 0.60
113_T 156_A 1.042 0.60
25_I 167_T 1.041 0.60
105_S 149_S 1.041 0.60
109_I 120_H 1.035 0.60
102_V 117_D 1.034 0.59
30_S 110_E 1.034 0.59
9_L 169_L 1.032 0.59
32_C 56_G 1.029 0.59
20_G 46_E 1.02 0.58
100_V 108_L 1.02 0.58
15_G 36_I 1.018 0.58
115_L 119_H 1.017 0.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2nyiA20.97371000.441Contact Map0.302
1u8sA20.97371000.45Contact Map0.249
3p96A10.957999.90.569Contact Map0.181
3n0vA40.921199.50.704Contact Map0.279
3nrbA40.905399.50.711Contact Map0.282
3louA40.999.50.714Contact Map0.255
3obiA40.999.40.722Contact Map0.236
3o1lA20.905399.40.726Contact Map0.247
2f06A20.747498.70.797Contact Map0.137
1zpvA30.473798.70.8Contact Map0.254
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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