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OPENSEQ.org
MODE - Transcriptional regulator ModE
UniProt: P0A9G8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13227
Length: 262 (262)
Sequences: 298
Seq/Len: 1.14
MODE
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
26_K 90_D 2.348 0.99
149_V 180_I 2.314 0.99
29_A 83_Q 1.903 0.95
198_N 234_P 1.881 0.95
189_I 221_M 1.866 0.94
251_F 256_V 1.842 0.94
138_R 174_E 1.812 0.93
61_H 231_A 1.723 0.90
200_D 252_N 1.69 0.89
20_R 41_A 1.632 0.87
131_W 182_L 1.623 0.87
133_G 149_V 1.586 0.85
135_I 207_I 1.586 0.85
180_I 256_V 1.567 0.84
120_R 130_Q 1.551 0.83
27_H 31_S 1.516 0.81
135_I 174_E 1.478 0.79
145_Q 167_G 1.449 0.77
203_L 223_L 1.44 0.76
76_A 99_A 1.44 0.76
145_Q 164_A 1.431 0.76
148_D 210_I 1.427 0.75
221_M 247_V 1.425 0.75
50_D 166_S 1.417 0.74
59_S 219_V 1.412 0.74
5_I 8_T 1.378 0.72
241_L 247_V 1.368 0.71
204_P 248_T 1.366 0.71
198_N 252_N 1.361 0.70
234_P 253_A 1.351 0.69
143_V 213_G 1.348 0.69
215_E 234_P 1.347 0.69
123_L 252_N 1.34 0.68
161_A 232_T 1.326 0.67
86_I 89_Y 1.325 0.67
158_L 256_V 1.325 0.67
96_Q 99_A 1.318 0.67
125_T 166_S 1.317 0.67
173_D 242_Q 1.306 0.66
27_H 30_L 1.299 0.65
53_N 66_R 1.293 0.64
63_L 66_R 1.292 0.64
178_V 260_T 1.289 0.64
39_K 133_G 1.276 0.63
41_A 150_L 1.276 0.63
216_Q 225_D 1.268 0.62
163_T 183_K 1.258 0.61
125_T 181_L 1.257 0.61
220_L 229_L 1.255 0.61
1_M 5_I 1.253 0.61
149_V 178_V 1.247 0.60
50_D 71_K 1.236 0.59
47_S 125_T 1.221 0.58
207_I 217_C 1.219 0.58
194_A 258_I 1.217 0.58
80_R 83_Q 1.217 0.58
92_L 162_I 1.214 0.57
189_I 207_I 1.21 0.57
207_I 241_L 1.21 0.57
200_D 234_P 1.206 0.56
199_A 249_A 1.205 0.56
205_G 221_M 1.202 0.56
171_G 242_Q 1.197 0.56
84_R 184_A 1.193 0.55
120_R 259_A 1.188 0.55
63_L 133_G 1.185 0.54
32_G 73_G 1.174 0.53
147_V 171_G 1.174 0.53
89_Y 187_V 1.174 0.53
52_I 164_A 1.166 0.53
23_S 27_H 1.165 0.53
181_L 251_F 1.161 0.52
72_G 120_R 1.16 0.52
90_D 93_A 1.155 0.52
188_G 198_N 1.151 0.51
185_P 252_N 1.15 0.51
141_D 234_P 1.147 0.51
160_V 189_I 1.14 0.50
8_T 96_Q 1.139 0.50
216_Q 252_N 1.136 0.50
82_G 85_L 1.133 0.50
28_I 63_L 1.132 0.49
108_A 160_V 1.131 0.49
60_E 63_L 1.128 0.49
89_Y 251_F 1.122 0.48
186_W 255_S 1.119 0.48
20_R 43_I 1.118 0.48
190_T 221_M 1.118 0.48
141_D 213_G 1.117 0.48
234_P 252_N 1.115 0.48
83_Q 242_Q 1.115 0.48
158_L 210_I 1.115 0.48
198_N 215_E 1.111 0.47
59_S 63_L 1.097 0.46
159_K 171_G 1.093 0.46
135_I 162_I 1.092 0.46
94_Q 122_S 1.092 0.46
93_A 257_I 1.087 0.45
197_Q 250_Y 1.082 0.45
81_Y 89_Y 1.081 0.45
118_I 186_W 1.08 0.44
28_I 62_I 1.072 0.44
52_I 64_V 1.072 0.44
166_S 184_A 1.071 0.44
141_D 215_E 1.07 0.43
28_I 78_L 1.064 0.43
173_D 193_E 1.061 0.43
67_A 248_T 1.061 0.43
191_Q 219_V 1.061 0.43
56_N 203_L 1.06 0.43
28_I 223_L 1.057 0.42
142_D 215_E 1.057 0.42
126_S 166_S 1.052 0.42
136_T 174_E 1.048 0.41
158_L 178_V 1.046 0.41
204_P 246_N 1.041 0.41
189_I 247_V 1.031 0.40
70_G 74_G 1.031 0.40
83_Q 110_P 1.03 0.40
217_C 235_V 1.027 0.39
26_K 176_K 1.025 0.39
207_I 233_V 1.023 0.39
26_K 81_Y 1.023 0.39
199_A 244_G 1.019 0.39
135_I 149_V 1.018 0.39
24_L 127_A 1.017 0.39
123_L 230_C 1.017 0.39
241_L 253_A 1.017 0.39
64_V 241_L 1.017 0.39
138_R 205_G 1.016 0.38
147_V 207_I 1.014 0.38
59_S 120_R 1.013 0.38
32_G 74_G 1.009 0.38
5_I 92_L 1.007 0.38
138_R 144_Q 1.006 0.38
116_A 251_F 1.006 0.38
240_S 258_I 1.001 0.37
52_I 56_N 1 0.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1b9mA211000.638Contact Map0.314
1fr3A120.255799.70.82Contact Map0.65
1gutA60.259599.70.821Contact Map0.61
2ijlA20.488599.60.824Contact Map0.427
1h9mA20.54299.20.861Contact Map0.353
1uthA10.938998.40.895Contact Map0.023
2h98A20.877998.30.899Contact Map0.039
2esnA40.885598.30.901Contact Map0.336
1al3A10.893198.30.901Contact Map0.059
1ixcA20.881798.20.902Contact Map0.268
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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