OPENSEQ.org - MNTR - ECOLI GREMLIN

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MNTR - Transcriptional regulator MntR

UniProt:	P0A9F1	Sequence MSRRAGTPTAKKVTQLVNVEEHVEGFRQVREAHRRELIDDYVELISDLIREVGEARQVDMAARLGVSQPTVAKMLKRLATMGLIEMIPWRGVFLTAEGEKLAQESRERHQIVENFLLVLGVSPEIARRDAEGMEHHVSEETLDAFRLFTQKHGAK	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG13322
Length:	155 (127)
Sequences:	813
Seq/Len:	6.40

MNTR
Paralog alert: 0.10 [within 20: 0.00] - ratio of genomes with paralogs

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
37_L	70_T	3.095	1.00
75_L	84_I	2.483	1.00
129_D	138_S	2.439	1.00
113_E	127_R	2.139	1.00
57_Q	71_V	1.989	1.00
45_I	84_I	1.931	1.00
49_I	99_E	1.874	1.00
125_I	140_E	1.837	1.00
38_I	81_M	1.818	1.00
122_S	125_I	1.775	1.00
72_A	86_M	1.614	1.00
107_E	146_R	1.535	0.99
68_Q	74_M	1.519	0.99
96_A	99_E	1.474	0.99
39_D	135_H	1.412	0.99
86_M	89_W	1.402	0.98
99_E	103_Q	1.383	0.98
97_E	100_K	1.371	0.98
116_L	133_M	1.359	0.98
132_G	136_H	1.354	0.98
38_I	74_M	1.354	0.98
112_V	145_F	1.326	0.98
121_V	129_D	1.322	0.98
119_L	148_F	1.311	0.97
115_F	119_L	1.305	0.97
43_E	109_H	1.287	0.97
112_V	137_V	1.276	0.97
131_E	135_H	1.276	0.97
137_V	142_L	1.235	0.96
42_V	46_S	1.227	0.96
104_E	139_E	1.227	0.96
67_S	73_K	1.216	0.95
39_D	105_S	1.169	0.94
112_V	141_T	1.165	0.94
85_E	93_F	1.165	0.94
40_D	131_E	1.163	0.94
74_M	77_R	1.144	0.93
143_D	147_L	1.143	0.93
44_L	60_M	1.141	0.93
145_F	148_F	1.134	0.93
139_E	143_D	1.133	0.93
82_G	99_E	1.132	0.93
45_I	71_V	1.129	0.92
83_L	97_E	1.112	0.92
44_L	63_R	1.111	0.92
43_E	141_T	1.11	0.92
48_L	59_D	1.107	0.91
147_L	150_Q	1.102	0.91
58_V	73_K	1.087	0.90
82_G	85_E	1.077	0.90
79_A	86_M	1.072	0.90
60_M	95_T	1.072	0.90
70_T	74_M	1.068	0.89
39_D	134_E	1.066	0.89
45_I	60_M	1.06	0.89
71_V	75_L	1.057	0.89
51_E	63_R	1.056	0.89
129_D	136_H	1.05	0.88
72_A	76_K	1.025	0.87
144_A	147_L	1.025	0.87
49_I	55_A	1.016	0.86
52_V	80_T	1.015	0.86
116_L	138_S	1.008	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
1fx7A	4	0.8065	99.9	0.573	Contact Map	0.627
3hrsA	2	0.7806	99.9	0.578	Contact Map	0.578
2qq9A	1	0.8065	99.9	0.58	Contact Map	0.523
2h09A	1	1	99.9	0.605	Contact Map	0.475
1on2A	2	0.7935	99.8	0.633	Contact Map	0.615
2p8tA	1	0.7742	99.7	0.656	Contact Map	0.361
2x4hA	4	0.8387	99.6	0.684	Contact Map	0.608
2fxaA	4	0.9677	99.1	0.765	Contact Map	0.515
2qvoA	1	0.5935	98.8	0.789	Contact Map	0.656
2o0mA	1	0.8645	98.8	0.795	Contact Map	0.071

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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