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DAPD - 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
UniProt: P0A9D8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10207
Length: 274 (273)
Sequences: 490
Seq/Len: 1.79
DAPD
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
197_E 226_R 4.52 1.00
197_E 229_A 4.498 1.00
135_D 154_K 3.712 1.00
216_D 255_K 3.183 1.00
152_I 164_I 3.143 1.00
190_V 202_I 3.135 1.00
34_V 59_L 2.926 1.00
119_R 136_E 2.681 1.00
57_Q 174_N 2.553 1.00
94_D 97_R 2.512 1.00
181_N 198_E 2.505 1.00
200_S 231_S 2.426 1.00
108_P 127_Y 2.248 1.00
34_V 43_L 2.183 0.99
23_A 69_I 2.179 0.99
14_R 17_E 2.141 0.99
95_E 99_Q 2.055 0.99
43_L 59_L 2.005 0.99
146_V 158_L 1.998 0.99
158_L 191_V 1.98 0.99
118_A 135_D 1.969 0.98
116_F 119_R 1.951 0.98
265_G 268_E 1.948 0.98
179_E 198_E 1.938 0.98
179_E 200_S 1.909 0.98
114_G 130_I 1.894 0.98
226_R 229_A 1.826 0.97
71_D 99_Q 1.817 0.97
111_V 115_A 1.81 0.97
49_I 56_H 1.799 0.97
237_N 246_S 1.781 0.97
5_Q 9_E 1.732 0.96
37_L 42_A 1.73 0.96
200_S 235_S 1.729 0.96
56_H 59_L 1.713 0.95
10_T 14_R 1.708 0.95
39_D 89_K 1.663 0.94
240_S 245_Y 1.645 0.94
48_K 52_Q 1.641 0.94
72_N 83_F 1.609 0.93
37_L 43_L 1.606 0.93
31_V 69_I 1.606 0.93
213_R 249_C 1.604 0.93
47_E 56_H 1.599 0.93
155_N 181_N 1.581 0.92
48_K 54_V 1.58 0.92
223_H 255_K 1.58 0.92
27_T 31_V 1.555 0.91
194_V 210_Q 1.553 0.91
48_K 198_E 1.552 0.91
93_Y 101_E 1.546 0.91
223_H 227_V 1.538 0.91
203_S 235_S 1.528 0.90
121_T 135_D 1.528 0.90
218_E 255_K 1.528 0.90
152_I 156_V 1.51 0.90
162_V 188_S 1.49 0.89
138_T 142_T 1.487 0.89
36_A 40_S 1.46 0.88
241_K 244_K 1.46 0.88
144_A 162_V 1.436 0.86
258_A 262_G 1.417 0.85
240_S 244_K 1.416 0.85
82_Y 108_P 1.381 0.83
196_V 208_I 1.361 0.82
216_D 223_H 1.313 0.79
28_R 119_R 1.313 0.79
158_L 162_V 1.313 0.79
207_Y 248_Y 1.305 0.78
74_V 81_R 1.284 0.77
229_A 255_K 1.257 0.75
191_V 210_Q 1.224 0.72
39_D 113_Q 1.223 0.72
82_Y 105_V 1.22 0.71
191_V 208_I 1.213 0.71
176_T 210_Q 1.213 0.71
105_V 109_A 1.194 0.69
145_T 160_G 1.186 0.68
247_L 251_V 1.177 0.67
160_G 187_R 1.171 0.67
76_E 81_R 1.165 0.66
162_V 191_V 1.165 0.66
194_V 203_S 1.163 0.66
146_V 156_V 1.161 0.66
174_N 209_G 1.141 0.64
188_S 191_V 1.138 0.64
64_L 171_L 1.128 0.63
97_R 100_K 1.121 0.62
110_A 127_Y 1.116 0.61
72_N 130_I 1.108 0.61
188_S 207_Y 1.106 0.60
182_C 200_S 1.106 0.60
176_T 191_V 1.105 0.60
202_I 235_S 1.095 0.59
49_I 52_Q 1.088 0.58
32_N 70_N 1.087 0.58
235_S 248_Y 1.082 0.58
199_G 230_G 1.08 0.58
33_Q 37_L 1.079 0.58
7_I 27_T 1.069 0.56
10_T 13_E 1.068 0.56
152_I 158_L 1.059 0.55
100_K 190_V 1.059 0.55
198_E 229_A 1.058 0.55
81_R 94_D 1.058 0.55
18_I 22_N 1.054 0.55
143_W 160_G 1.032 0.53
143_W 187_R 1.028 0.52
118_A 136_E 1.025 0.52
82_Y 88_M 1.021 0.51
75_I 108_P 1.02 0.51
24_D 27_T 1.015 0.51
68_R 134_V 1.014 0.51
190_V 208_I 1.014 0.51
97_R 272_T 1.01 0.50
203_S 209_G 1.008 0.50
202_I 215_Y 1.008 0.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3gosA311000.541Contact Map0.694
3tk8A30.99641000.558Contact Map0.639
3eg4A10.98911000.612Contact Map0.593
3fsyA50.89421000.779Contact Map0.343
2rijA10.941699.90.812Contact Map0.297
3r5dA60.923499.90.813Contact Map0.37
3r8yA60.821299.90.818Contact Map0.548
2iu8A30.985499.90.818Contact Map0.353
3pmoA10.996499.80.855Contact Map0.282
4e79A30.985499.70.867Contact Map0.377
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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