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OPENSEQ.org
GLPX - Fructose-1,6-bisphosphatase 1 class 2
UniProt: P0A9C9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11517
Length: 336 (315)
Sequences: 570
Seq/Len: 1.81
GLPX
Paralog alert: 0.30 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: GLPX2 GLPX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
161_I 174_M 5.373 1.00
140_A 173_E 3.198 1.00
28_D 31_T 2.851 1.00
50_D 79_A 2.77 1.00
143_L 157_L 2.743 1.00
50_D 71_K 2.624 1.00
192_S 217_S 2.606 1.00
304_E 319_Q 2.475 1.00
171_I 183_A 2.407 1.00
21_Y 296_R 2.398 1.00
146_V 204_V 2.393 1.00
222_R 270_G 2.386 1.00
34_G 38_N 2.371 1.00
136_N 231_R 2.36 1.00
10_S 305_T 2.335 1.00
159_V 204_V 2.312 1.00
139_L 206_Y 2.312 1.00
124_I 221_I 2.305 1.00
123_L 133_I 2.227 1.00
254_A 258_A 2.222 0.99
208_I 233_L 2.195 0.99
172_A 176_Q 2.18 0.99
228_M 269_L 2.116 0.99
169_A 173_E 2.072 0.99
115_A 118_M 2.068 0.99
235_R 252_E 2.031 0.99
52_T 109_K 2.03 0.99
121_E 231_R 1.982 0.99
174_M 179_V 1.981 0.99
79_A 109_K 1.96 0.98
136_N 266_V 1.95 0.98
143_L 204_V 1.932 0.98
143_L 154_L 1.928 0.98
133_I 146_V 1.873 0.98
135_L 266_V 1.779 0.97
52_T 71_K 1.774 0.97
87_I 285_I 1.727 0.96
222_R 273_A 1.724 0.96
131_G 227_D 1.723 0.96
135_L 231_R 1.71 0.96
235_R 249_G 1.703 0.95
134_D 266_V 1.624 0.94
196_C 221_I 1.604 0.93
128_G 150_L 1.591 0.93
154_L 179_V 1.556 0.92
170_V 206_Y 1.552 0.91
137_L 141_D 1.509 0.90
3_R 309_R 1.487 0.89
125_V 204_V 1.482 0.89
91_R 95_M 1.481 0.89
108_D 277_N 1.477 0.89
82_I 106_V 1.472 0.88
115_A 255_R 1.428 0.86
284_G 288_G 1.418 0.86
92_M 185_P 1.416 0.86
159_V 206_Y 1.416 0.86
267_L 271_D 1.406 0.85
3_R 80_V 1.381 0.84
211_A 214_G 1.38 0.84
297_K 300_I 1.371 0.83
20_G 102_A 1.358 0.82
309_R 314_T 1.358 0.82
117_D 255_R 1.344 0.81
68_I 211_A 1.328 0.80
161_I 171_I 1.323 0.80
18_L 301_A 1.321 0.80
143_L 177_L 1.295 0.78
219_A 278_V 1.282 0.77
11_R 309_R 1.281 0.77
160_T 191_A 1.27 0.76
141_D 145_N 1.266 0.76
117_D 211_A 1.262 0.75
261_I 265_K 1.261 0.75
68_I 115_A 1.238 0.73
99_N 191_A 1.238 0.73
168_D 172_A 1.232 0.73
302_T 319_Q 1.227 0.72
121_E 208_I 1.222 0.72
61_D 90_T 1.218 0.72
113_L 211_A 1.216 0.71
134_D 229_N 1.202 0.70
32_A 93_T 1.2 0.70
108_D 275_S 1.199 0.70
3_R 11_R 1.194 0.69
169_A 172_A 1.175 0.68
182_F 289_D 1.174 0.68
9_F 190_A 1.168 0.67
121_E 135_L 1.168 0.67
165_P 168_D 1.157 0.66
61_D 65_M 1.154 0.66
116_P 215_V 1.152 0.65
161_I 207_G 1.151 0.65
229_N 266_V 1.142 0.64
123_L 320_S 1.136 0.64
152_K 203_D 1.134 0.64
101_L 160_T 1.132 0.63
304_E 317_R 1.13 0.63
52_T 114_N 1.125 0.63
72_V 193_I 1.118 0.62
137_L 145_N 1.115 0.62
251_Q 254_A 1.108 0.61
214_G 230_G 1.104 0.61
249_G 252_E 1.094 0.59
227_D 269_L 1.092 0.59
163_A 168_D 1.091 0.59
71_K 109_K 1.088 0.59
59_E 65_M 1.085 0.59
90_T 212_P 1.085 0.59
32_A 87_I 1.082 0.58
133_I 142_N 1.078 0.58
68_I 117_D 1.076 0.58
113_L 117_D 1.074 0.57
265_K 271_D 1.073 0.57
111_C 274_R 1.067 0.57
151_G 154_L 1.054 0.55
205_L 216_V 1.053 0.55
125_V 227_D 1.053 0.55
253_L 264_G 1.051 0.55
86_P 90_T 1.049 0.55
123_L 149_A 1.046 0.54
160_T 184_I 1.045 0.54
60_I 235_R 1.042 0.54
254_A 257_K 1.042 0.54
115_A 211_A 1.041 0.54
262_E 265_K 1.035 0.53
65_M 90_T 1.034 0.53
8_E 108_D 1.033 0.53
107_G 112_F 1.033 0.53
200_S 281_S 1.029 0.53
250_E 253_L 1.027 0.52
22_K 301_A 1.024 0.52
8_E 312_S 1.021 0.52
124_I 228_M 1.019 0.51
48_N 74_T 1.019 0.51
129_A 146_V 1.018 0.51
30_N 87_I 1.016 0.51
59_E 64_P 1.016 0.51
68_I 114_N 1.012 0.51
9_F 106_V 1.011 0.51
44_L 104_L 1.007 0.50
72_V 278_V 1.005 0.50
161_I 181_V 1.003 0.50
255_R 259_M 1.002 0.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bigA111000.004Contact Map0.667
3rojA40.98811000.028Contact Map0.689
3b8bA10.690596.30.953Contact Map0.417
4g62A20.714395.20.957Contact Map0.366
1g0hA20.654894.90.958Contact Map0.483
4i3yA20.711394.20.959Contact Map0.271
1lbvA20.651893.60.96Contact Map0.305
3t0jA40.7593.60.96Contact Map0.412
2p3nA40.699492.50.961Contact Map0.446
2pcrA40.684592.30.962Contact Map0.47
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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