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OPENSEQ.org
E4PD - D-erythrose-4-phosphate dehydrogenase
UniProt: P0A9B6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10368
Length: 339 (334)
Sequences: 3051
Seq/Len: 9.13
E4PD
Paralog alert: 0.49 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: E4PD G3P1 G3P3
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
168_D 225_Q 4.485 1.00
80_E 85_S 4.283 1.00
174_E 252_K 3.796 1.00
277_D 293_H 3.485 1.00
165_K 169_D 3.428 1.00
82_S 85_S 3.427 1.00
110_E 114_A 3.399 1.00
170_A 266_K 3.106 1.00
140_Q 332_A 2.899 1.00
254_P 308_H 2.858 1.00
150_V 333_M 2.797 1.00
207_S 286_V 2.709 1.00
171_Y 263_L 2.641 1.00
108_H 111_A 2.615 1.00
184_A 205_S 2.548 1.00
295_A 314_V 2.512 1.00
4_R 31_T 2.509 1.00
294_S 325_R 2.5 1.00
264_L 297_V 2.488 1.00
183_S 239_T 2.369 1.00
59_W 71_G 2.318 1.00
241_N 289_N 2.28 1.00
282_P 300_T 2.152 1.00
262_L 266_K 2.15 1.00
175_S 250_T 2.137 1.00
208_I 235_V 2.099 1.00
136_Y 140_Q 2.072 1.00
164_I 226_F 2.068 1.00
83_L 103_Y 2.052 1.00
31_T 73_D 2.05 1.00
260_V 310_I 2.03 1.00
54_H 241_N 2.014 1.00
106_R 110_E 1.999 1.00
84_Q 114_A 1.966 1.00
242_V 288_F 1.945 1.00
220_T 227_N 1.918 1.00
325_R 328_D 1.912 1.00
21_L 32_V 1.895 1.00
43_G 198_L 1.893 1.00
235_V 244_A 1.885 1.00
67_Q 74_A 1.876 1.00
105_S 108_H 1.866 1.00
254_P 307_A 1.862 1.00
18_V 48_L 1.855 1.00
22_Y 57_F 1.848 1.00
18_V 32_V 1.819 1.00
52_T 286_V 1.816 1.00
265_Q 280_E 1.81 1.00
64_E 74_A 1.793 1.00
87_P 90_E 1.786 1.00
277_D 291_D 1.78 1.00
253_K 259_E 1.76 1.00
104_G 122_F 1.757 1.00
291_D 296_I 1.744 1.00
174_E 250_T 1.742 1.00
49_K 281_L 1.74 1.00
52_T 206_Q 1.734 1.00
265_Q 269_Q 1.697 1.00
251_V 310_I 1.68 1.00
142_Q 225_Q 1.678 1.00
123_S 326_M 1.669 1.00
64_E 67_Q 1.625 1.00
46_H 201_T 1.619 1.00
99_C 123_S 1.597 1.00
203_A 206_Q 1.596 1.00
76_R 90_E 1.591 1.00
4_R 92_G 1.586 1.00
283_L 288_F 1.584 1.00
166_L 276_V 1.578 1.00
200_R 211_V 1.572 1.00
257_A 302_T 1.556 1.00
174_E 308_H 1.554 1.00
256_K 259_E 1.551 1.00
278_Y 299_G 1.54 1.00
121_L 330_T 1.54 1.00
20_A 324_N 1.533 1.00
231_E 303_R 1.532 1.00
167_L 264_L 1.527 1.00
10_F 48_L 1.502 1.00
110_E 113_I 1.479 1.00
18_V 70_V 1.477 1.00
119_K 148_R 1.476 1.00
171_Y 251_V 1.473 1.00
164_I 173_I 1.468 1.00
57_F 71_G 1.452 1.00
176_G 230_F 1.444 1.00
97_L 330_T 1.437 0.99
46_H 198_L 1.432 0.99
78_L 91_L 1.419 0.99
82_S 111_A 1.419 0.99
279_T 288_F 1.402 0.99
121_L 150_V 1.398 0.99
170_A 263_L 1.398 0.99
293_H 296_I 1.359 0.99
221_R 227_N 1.353 0.99
84_Q 111_A 1.349 0.99
23_E 58_A 1.343 0.99
279_T 283_L 1.336 0.99
280_E 299_G 1.304 0.99
95_V 330_T 1.304 0.99
292_P 324_N 1.295 0.99
197_D 200_R 1.293 0.99
292_P 320_W 1.292 0.99
251_V 255_V 1.286 0.99
167_L 312_T 1.264 0.98
163_V 312_T 1.258 0.98
163_V 314_V 1.255 0.98
105_S 128_N 1.247 0.98
34_A 78_L 1.241 0.98
190_V 204_A 1.238 0.98
67_Q 76_R 1.233 0.98
268_A 271_A 1.233 0.98
99_C 326_M 1.233 0.98
56_R 291_D 1.233 0.98
255_V 304_V 1.232 0.98
261_N 302_T 1.232 0.98
304_V 307_A 1.231 0.98
163_V 295_A 1.23 0.98
132_A 142_Q 1.229 0.98
294_S 328_D 1.225 0.98
265_Q 278_Y 1.217 0.98
86_L 91_L 1.214 0.98
18_V 75_I 1.211 0.98
168_D 223_F 1.21 0.98
206_Q 240_I 1.209 0.98
172_G 251_V 1.202 0.98
86_L 115_A 1.198 0.97
95_V 121_L 1.192 0.97
126_G 133_T 1.182 0.97
109_G 122_F 1.176 0.97
6_A 86_L 1.169 0.97
186_H 191_I 1.165 0.97
134_V 147_H 1.163 0.97
263_L 266_K 1.161 0.97
97_L 326_M 1.157 0.97
6_A 115_A 1.156 0.97
286_V 289_N 1.154 0.97
187_D 195_H 1.152 0.97
163_V 264_L 1.151 0.97
132_A 147_H 1.143 0.96
250_T 308_H 1.141 0.96
170_A 174_E 1.137 0.96
272_F 276_V 1.123 0.96
320_W 324_N 1.115 0.96
17_V 326_M 1.114 0.96
168_D 252_K 1.107 0.95
41_A 77_V 1.106 0.95
66_D 76_R 1.086 0.95
187_D 200_R 1.085 0.95
262_L 265_Q 1.084 0.95
126_G 130_L 1.083 0.95
105_S 129_D 1.082 0.95
203_A 240_I 1.08 0.95
181_I 235_V 1.079 0.95
133_T 221_R 1.078 0.95
186_H 193_A 1.074 0.94
171_Y 255_V 1.067 0.94
34_A 91_L 1.063 0.94
107_E 110_E 1.06 0.94
64_E 69_F 1.058 0.94
110_E 149_I 1.057 0.94
144_R 147_H 1.052 0.94
255_V 260_V 1.048 0.93
189_Q 193_A 1.046 0.93
16_N 54_H 1.046 0.93
199_R 298_D 1.046 0.93
266_K 270_G 1.038 0.93
266_K 271_A 1.037 0.93
259_E 262_L 1.016 0.92
266_K 269_Q 1.013 0.92
255_V 263_L 1.011 0.92
167_L 251_V 1.005 0.91
205_S 240_I 1.005 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3docA40.98821000.219Contact Map0.836
3idsC40.98821000.22Contact Map0.748
2x5jO411000.223Contact Map0.806
1rm4O30.98821000.224Contact Map0.779
4lsmA20.97641000.226Contact Map0.746
2ep7A20.98231000.23Contact Map0.746
1obfO20.98821000.231Contact Map0.739
3b1jA20.99121000.233Contact Map0.731
3hjaA40.97351000.235Contact Map0.789
3cpsA20.98531000.236Contact Map0.694
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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